Ring-Expansion Reaction of Oximes with Aluminum Reductants
AbstractThe ring-expansion reactions of heterocyclic ketoximes and carbocyclic ketoximes with several reductants such as AlHCl2, AlH3 (alane), LiAlH4, LiAlH(OtBu)3, and (MeOCH2CH2O)2AlH2Na (Red-Al) were examined. Among reductants, AlHCl2 (LiAlH4:AlCl3 = 1:3) in cyclopentyl methyl ether (CPME) has been found to be a suitable reagent for the reaction, and the rearranged cyclic secondary amines were obtained in good to excellent yields.
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Cho, H.; Iwama, Y.; Mitsuhashi, N.; Sugimoto, K.; Okano, K.; Tokuyama, H. Ring-Expansion Reaction of Oximes with Aluminum Reductants. Molecules 2012, 17, 7348-7355.
Cho H, Iwama Y, Mitsuhashi N, Sugimoto K, Okano K, Tokuyama H. Ring-Expansion Reaction of Oximes with Aluminum Reductants. Molecules. 2012; 17(6):7348-7355.Chicago/Turabian Style
Cho, Hidetsura; Iwama, Yusuke; Mitsuhashi, Nakako; Sugimoto, Kenji; Okano, Kentaro; Tokuyama, Hidetoshi. 2012. "Ring-Expansion Reaction of Oximes with Aluminum Reductants." Molecules 17, no. 6: 7348-7355.