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Molecules 2012, 17(7), 8674-8686; doi:10.3390/molecules17078674

Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives

1, 1, 1, 1,* , 2, 2 and 2,*
1 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union, Medical College, Beijing 100050, China 2 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
* Authors to whom correspondence should be addressed.
Received: 8 June 2012 / Revised: 28 June 2012 / Accepted: 13 July 2012 / Published: 23 July 2012
(This article belongs to the Special Issue Heterocycles)
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A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For comparison the reactions were carried out under both conventional and ultrasonic conditions. In general, improvement in rates and yields were observed when the reactions were carried out under sonication compared with classical conditions.
Keywords: multicomponent; ultrasound; spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]; spirooxindole multicomponent; ultrasound; spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]; spirooxindole
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, J.; Bai, X.; Xu, C.; Wang, Y.; Lin, W.; Zou, Y.; Shi, D. Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives. Molecules 2012, 17, 8674-8686.

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