Molecules 2012, 17(7), 8674-8686; doi:10.3390/molecules17078674
Article

Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives

1, 1, 1, 1,* email, 2, 2 and 2,* email
Received: 8 June 2012; in revised form: 28 June 2012 / Accepted: 13 July 2012 / Published: 23 July 2012
(This article belongs to the Special Issue Heterocycles)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For comparison the reactions were carried out under both conventional and ultrasonic conditions. In general, improvement in rates and yields were observed when the reactions were carried out under sonication compared with classical conditions.
Keywords: multicomponent; ultrasound; spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]; spirooxindole
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MDPI and ACS Style

Wang, J.; Bai, X.; Xu, C.; Wang, Y.; Lin, W.; Zou, Y.; Shi, D. Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives. Molecules 2012, 17, 8674-8686.

AMA Style

Wang J, Bai X, Xu C, Wang Y, Lin W, Zou Y, Shi D. Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives. Molecules. 2012; 17(7):8674-8686.

Chicago/Turabian Style

Wang, Juxian; Bai, Xiaoguang; Xu, Changliang; Wang, Yucheng; Lin, Wei; Zou, Yi; Shi, Daqing. 2012. "Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives." Molecules 17, no. 7: 8674-8686.

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