Molecules 2012, 17(6), 6944-6952; doi:10.3390/molecules17066944
Article

Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity

Key Laboratory of Marine Bio-resourses Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
* Author to whom correspondence should be addressed.
Received: 30 March 2012; in revised form: 11 May 2012 / Accepted: 11 May 2012 / Published: 6 June 2012
(This article belongs to the Special Issue Coumarins and Xanthones)
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Abstract: Two new coumarins, 7-methoxy-8-(2-hydroxmethyl-1-O-isovaleryl-4-butenyl)-coumarin (1) and 7-methoxy-8-(1-hydroxy-2-O-b-glucopyranosyl-3-methyl-4-butene-1-yl)coumarin (2), and twelve known coumarins 3–14 were isolated from the stem bark of Micromelum falcatum. The structures of compounds 1–14 were elucidated by extensive spectroscopic data analyses. The toxicity of compounds 1–14 was tested using a brine shrimp assay and in vitro antiproliferative assay against mammary cancer (F10) and lung cancer (HvEvc) cell lines by the MTT method. Some compounds had moderate activities. All compounds were also tested against the microorganisms Bacillus subtilis, Bacillus thuringiensis and Escherichia coli, but no activity was observed.
Keywords: Micromelum falcatum; coumarins; brine shrimp larvae toxicity; cytotoxicity; antibacterial activity

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MDPI and ACS Style

Luo, X.; He, W.; Yin, H.; Li, Q.; Liu, Q.; Huang, Y.; Zhang, S. Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity. Molecules 2012, 17, 6944-6952.

AMA Style

Luo X, He W, Yin H, Li Q, Liu Q, Huang Y, Zhang S. Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity. Molecules. 2012; 17(6):6944-6952.

Chicago/Turabian Style

Luo, Xiongming; He, Weihong; Yin, Hao; Li, Qingxin; Liu, Qiao; Huang, Yongzhong; Zhang, Si. 2012. "Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity." Molecules 17, no. 6: 6944-6952.

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