Molecules 2012, 17(6), 6728-6753; doi:10.3390/molecules17066728
Review

The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth

Received: 30 March 2012; in revised form: 1 May 2012 / Accepted: 28 May 2012 / Published: 4 June 2012
(This article belongs to the collection Bioactive Compounds)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Neurite loss is one of the cardinal features of neuronal injury. Apart from neuroprotection, reorganization of the lost neuronal network in the injured brain is necessary for the restoration of normal physiological functions. Neuritogenic activity of endogenous molecules in the brain such as nerve growth factor is well documented and supported by scientific studies which show innumerable compounds having neurite outgrowth activity from natural sources. Since the damaged brain lacks the reconstructive capacity, more efforts in research are focused on the identification of compounds that promote the reformation of neuronal networks. An abundancy of natural resources along with the corresponding activity profiles have shown promising results in the field of neuroscience. Recently, importance has also been placed on understanding neurite formation by natural products in relation to neuronal injury. Arrays of natural herbal products having plentiful active constituents have been found to enhance neurite outgrowth. They act synergistically with neurotrophic factors to promote neuritogenesis in the diseased brain. Therefore use of natural products for neuroregeneration provides new insights in drug development for treating neuronal injury. In this study, various compounds from natural sources with potential neurite outgrowth activity are reviewed in experimental models.
Keywords: neurite outgrowth; neuroregeneration; neuritogenesis; natural molecules; neurodegeneration
PDF Full-text Download PDF Full-Text [316 KB, uploaded 18 June 2014 19:49 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

More, S.V.; Koppula, S.; Kim, I.-S.; Kumar, H.; Kim, B.-W.; Choi, D.-K. The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth. Molecules 2012, 17, 6728-6753.

AMA Style

More SV, Koppula S, Kim I-S, Kumar H, Kim B-W, Choi D-K. The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth. Molecules. 2012; 17(6):6728-6753.

Chicago/Turabian Style

More, Sandeep Vasant; Koppula, Sushruta; Kim, In-Su; Kumar, Hemant; Kim, Byung-Wook; Choi, Dong-Kug. 2012. "The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth." Molecules 17, no. 6: 6728-6753.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert