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Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis
Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Cx. Postal 5069, CEP 88040-970, Florianópolis, SC, Brazil
Universidade Federal da Fronteira Sul, Campus Universitário Laranjeiras do Sul, Bairro Vila Alberti, CEP 85303-775, Laranjeiras do Sul, PR, Brazil
Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil
* Author to whom correspondence should be addressed.
Received: 12 April 2012; in revised form: 11 May 2012 / Accepted: 13 May 2012 / Published: 4 June 2012
Abstract: In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the n-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the n-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. In vitro incubation with the crude extract and n-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs). Thus, the results demonstrated that B. articulata exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for B. articulata indicate potential anti-diabetic properties.
Keywords: Baccharis articulata; diabetes; insulin; disaccharidase; glycation
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Kappel, V.D.; Pereira, D.F.; Cazarolli, L.H.; Guesser, S.M.; da Silva, C.H.B.; Schenkel, E.P.; Reginatto, F.H.; Silva, F.R.M.B. Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis. Molecules 2012, 17, 6754-6768.
Kappel VD, Pereira DF, Cazarolli LH, Guesser SM, da Silva CHB, Schenkel EP, Reginatto FH, Silva FRMB. Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis. Molecules. 2012; 17(6):6754-6768.
Kappel, Virginia D.; Pereira, Danielle F.; Cazarolli, Luisa H.; Guesser, Samantha M.; da Silva, Carlos H. Blum; Schenkel, Eloir P.; Reginatto, Flávio H.; Silva, Fátima R. M. B. 2012. "Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis." Molecules 17, no. 6: 6754-6768.