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Molecules 2012, 17(4), 4219-4224; doi:10.3390/molecules17044219
Article

A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031

1, 1, 1, 1, 1, 1 and 2,*
Received: 5 March 2012; in revised form: 20 March 2012 / Accepted: 26 March 2012 / Published: 5 April 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract: Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 14 showed potent antioxidant activity with EC50 values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
Keywords: Cephalosporium sp.AL031 fungus; isobenzofuranone; antioxidant activity Cephalosporium sp.AL031 fungus; isobenzofuranone; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, X.-Z.; Zhu, Y.; Guan, X.-L.; Tian, K.; Guo, J.-M.; Wang, H.-B.; Fu, G.-M. A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031. Molecules 2012, 17, 4219-4224.

AMA Style

Huang X-Z, Zhu Y, Guan X-L, Tian K, Guo J-M, Wang H-B, Fu G-M. A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031. Molecules. 2012; 17(4):4219-4224.

Chicago/Turabian Style

Huang, Xiang-Zhong; Zhu, Yun; Guan, Xiao-Li; Tian, Kai; Guo, Jun-Ming; Wang, Hong-Bin; Fu, Guang-Miao. 2012. "A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031." Molecules 17, no. 4: 4219-4224.



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