Molecules 2012, 17(4), 4219-4224; doi:10.3390/molecules17044219
Article

A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031

Xiang-Zhong Huang 1 , Yun Zhu 1 , Xiao-Li Guan 1 , Kai Tian 1 , Jun-Ming Guo 1 , Hong-Bin Wang 1  and Guang-Miao Fu 2,* email
1 Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China 2 School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China
* Author to whom correspondence should be addressed.
Received: 5 March 2012; in revised form: 20 March 2012 / Accepted: 26 March 2012 / Published: 5 April 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract: Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1–4 showed potent antioxidant activity with EC50 values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
Keywords: Cephalosporium sp.AL031 fungus; isobenzofuranone; antioxidant activity

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Cite This Article

MDPI and ACS Style

Huang, X.-Z.; Zhu, Y.; Guan, X.-L.; Tian, K.; Guo, J.-M.; Wang, H.-B.; Fu, G.-M. A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031. Molecules 2012, 17, 4219-4224.

AMA Style

Huang X-Z, Zhu Y, Guan X-L, Tian K, Guo J-M, Wang H-B, Fu G-M. A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031. Molecules. 2012; 17(4):4219-4224.

Chicago/Turabian Style

Huang, Xiang-Zhong; Zhu, Yun; Guan, Xiao-Li; Tian, Kai; Guo, Jun-Ming; Wang, Hong-Bin; Fu, Guang-Miao. 2012. "A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031." Molecules 17, no. 4: 4219-4224.

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