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Molecules 2012, 17(4), 4219-4224; doi:10.3390/molecules17044219

A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031

1, 1, 1, 1, 1, 1 and 2,*
1 Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China 2 School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China
* Author to whom correspondence should be addressed.
Received: 5 March 2012 / Revised: 20 March 2012 / Accepted: 26 March 2012 / Published: 5 April 2012
(This article belongs to the Section Medicinal Chemistry)
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Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 14 showed potent antioxidant activity with EC50 values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
Keywords: Cephalosporium sp.AL031 fungus; isobenzofuranone; antioxidant activity Cephalosporium sp.AL031 fungus; isobenzofuranone; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, X.-Z.; Zhu, Y.; Guan, X.-L.; Tian, K.; Guo, J.-M.; Wang, H.-B.; Fu, G.-M. A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031. Molecules 2012, 17, 4219-4224.

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