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A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031
Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China
School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China
* Author to whom correspondence should be addressed.
Received: 5 March 2012; in revised form: 20 March 2012 / Accepted: 26 March 2012 / Published: 5 April 2012
Abstract: Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1–4 showed potent antioxidant activity with EC50 values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
Keywords: Cephalosporium sp.AL031 fungus; isobenzofuranone; antioxidant activity
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Huang, X.-Z.; Zhu, Y.; Guan, X.-L.; Tian, K.; Guo, J.-M.; Wang, H.-B.; Fu, G.-M. A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031. Molecules 2012, 17, 4219-4224.
Huang X-Z, Zhu Y, Guan X-L, Tian K, Guo J-M, Wang H-B, Fu G-M. A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031. Molecules. 2012; 17(4):4219-4224.
Huang, Xiang-Zhong; Zhu, Yun; Guan, Xiao-Li; Tian, Kai; Guo, Jun-Ming; Wang, Hong-Bin; Fu, Guang-Miao. 2012. "A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031." Molecules 17, no. 4: 4219-4224.