Molecules 2012, 17(1), 1103-1112; doi:10.3390/molecules17011103
Communication

The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin

Abdul Latif Khan 1,2 email, Muhammad Hamayun 3 email, Javid Hussain 2,4 email, Sang-Mo Kang 1 email and In-Jung Lee 1,* email
1 School of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 702-701, Korea 2 Department of Plant Sciences, Kohat University of Science and Technology, Kohat 26000, Pakistan 3 Department of Botany, Abdul Wali Khan University, Mardan 23300, Pakistan 4 Department of Biological Sciences and Chemistry, College of Arts & Sciences, University of Nizwa, Nizwa 33, Oman
* Author to whom correspondence should be addressed.
Received: 19 December 2011; in revised form: 6 January 2012 / Accepted: 11 January 2012 / Published: 20 January 2012
(This article belongs to the Section Natural Products)
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Abstract: We have isolated five endophytic fungi from the roots of Capsicum annuum, Cucumis sativus and Glycine max. The culture filtrates (CF) of these endophytes were screened on dwarf mutant rice (Waito-C) and normal rice (Dongjin-byeo). Endophyte CAC-1A significantly inhibited the growth of Waito-C and Dongjin-byeo. Endophyte CAC-1A was identified as Paraconiothyrium sp. by sequencing the ITS rDNA region and phylogenetic analysis. The ethyl acetate fraction of Paraconiothyrium sp. suppressed the germination of Lactuca sativa and Echinochloa crus-galli seeds. The ethyl acetate fraction of the endophyte was subjected to bioassay-guided isolation and we obtained the phytotoxic compound ascotoxin (1) which was characterized through NMR and GC/MS techniques. Ascotoxin revealed 100% inhibitory effects on seed germination of Echinochloa crus-galli. Compound (1) was isolated for the first time from Paraconiothyrium sp.
Keywords: Paraconiothyrium sp.; ascotoxin; growth inhibitory effect; endophytic fungi

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MDPI and ACS Style

Khan, A.L.; Hamayun, M.; Hussain, J.; Kang, S.-M.; Lee, I.-J. The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin. Molecules 2012, 17, 1103-1112.

AMA Style

Khan AL, Hamayun M, Hussain J, Kang S-M, Lee I-J. The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin. Molecules. 2012; 17(1):1103-1112.

Chicago/Turabian Style

Khan, Abdul Latif; Hamayun, Muhammad; Hussain, Javid; Kang, Sang-Mo; Lee, In-Jung. 2012. "The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin." Molecules 17, no. 1: 1103-1112.

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