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Molecules 2011, 16(6), 4511-4526; doi:10.3390/molecules16064511

Locked and Unlocked Nucleosides in Functional Nucleic Acids

Nucleic Acid Center, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M 5230, Denmark
Author to whom correspondence should be addressed.
Received: 3 May 2011 / Revised: 19 May 2011 / Accepted: 25 May 2011 / Published: 27 May 2011
(This article belongs to the Special Issue Nucleoside Analogues)
Download PDF [188 KB, 18 June 2014; original version 18 June 2014]


Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
Keywords: locked nucleic acid (LNA); unlocked nucleic acid (UNA); aptamer; ribozyme; deoxyribozymes (DNAzyme) locked nucleic acid (LNA); unlocked nucleic acid (UNA); aptamer; ribozyme; deoxyribozymes (DNAzyme)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Doessing, H.; Vester, B. Locked and Unlocked Nucleosides in Functional Nucleic Acids. Molecules 2011, 16, 4511-4526.

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