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Locked and Unlocked Nucleosides in Functional Nucleic Acids
Nucleic Acid Center, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M 5230, Denmark
* Author to whom correspondence should be addressed.
Received: 3 May 2011; in revised form: 19 May 2011 / Accepted: 25 May 2011 / Published: 27 May 2011
Abstract: Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
Keywords: locked nucleic acid (LNA); unlocked nucleic acid (UNA); aptamer; ribozyme; deoxyribozymes (DNAzyme)
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Cite This Article
MDPI and ACS Style
Doessing, H.; Vester, B. Locked and Unlocked Nucleosides in Functional Nucleic Acids. Molecules 2011, 16, 4511-4526.
Doessing H, Vester B. Locked and Unlocked Nucleosides in Functional Nucleic Acids. Molecules. 2011; 16(6):4511-4526.
Doessing, Holger; Vester, Birte. 2011. "Locked and Unlocked Nucleosides in Functional Nucleic Acids." Molecules 16, no. 6: 4511-4526.