Next Article in Journal
Synthesis and Antimalarial Activity of Novel Dihydro-Artemisinin Derivatives
Next Article in Special Issue
Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly
Previous Article in Journal
Catalytic Synthesis of α-Oxoketene S,S-Acetals in a Wet Ionic Liquid [Bmim]Cl/H2O Homogeneous System
Previous Article in Special Issue
The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis
Molecules 2011, 16(6), 4511-4526; doi:10.3390/molecules16064511

Locked and Unlocked Nucleosides in Functional Nucleic Acids

Nucleic Acid Center, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M 5230, Denmark
* Author to whom correspondence should be addressed.
Received: 3 May 2011 / Revised: 19 May 2011 / Accepted: 25 May 2011 / Published: 27 May 2011
(This article belongs to the Special Issue Nucleoside Analogues)
Download PDF [188 KB, 18 June 2014; original version 18 June 2014]


Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
Keywords: locked nucleic acid (LNA); unlocked nucleic acid (UNA); aptamer; ribozyme; deoxyribozymes (DNAzyme) locked nucleic acid (LNA); unlocked nucleic acid (UNA); aptamer; ribozyme; deoxyribozymes (DNAzyme)
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Doessing, H.; Vester, B. Locked and Unlocked Nucleosides in Functional Nucleic Acids. Molecules 2011, 16, 4511-4526.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert