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Molecules 2011, 16(6), 4511-4526; doi:10.3390/molecules16064511
Review

Locked and Unlocked Nucleosides in Functional Nucleic Acids

 and *
Received: 3 May 2011; in revised form: 19 May 2011 / Accepted: 25 May 2011 / Published: 27 May 2011
(This article belongs to the Special Issue Nucleoside Analogues)
Download PDF [188 KB, updated 18 June 2014; original version uploaded 18 June 2014]
Abstract: Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
Keywords: locked nucleic acid (LNA); unlocked nucleic acid (UNA); aptamer; ribozyme; deoxyribozymes (DNAzyme) locked nucleic acid (LNA); unlocked nucleic acid (UNA); aptamer; ribozyme; deoxyribozymes (DNAzyme)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Doessing, H.; Vester, B. Locked and Unlocked Nucleosides in Functional Nucleic Acids. Molecules 2011, 16, 4511-4526.

AMA Style

Doessing H, Vester B. Locked and Unlocked Nucleosides in Functional Nucleic Acids. Molecules. 2011; 16(6):4511-4526.

Chicago/Turabian Style

Doessing, Holger; Vester, Birte. 2011. "Locked and Unlocked Nucleosides in Functional Nucleic Acids." Molecules 16, no. 6: 4511-4526.


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