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Molecules 2011, 16(6), 4912-4922; doi:10.3390/molecules16064912

Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly

1, 2, 3, 3 and 1,*
Received: 4 May 2011 / Revised: 31 May 2011 / Accepted: 10 June 2011 / Published: 15 June 2011
(This article belongs to the Special Issue Nucleoside Analogues)
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Abstract: We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.
Keywords: terpy-DNA; AFM; TEM; DNA nanotubes terpy-DNA; AFM; TEM; DNA nanotubes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Burns, J.R.; Zekonyte, J.; Siligardi, G.; Hussain, R.; Stulz, E. Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly. Molecules 2011, 16, 4912-4922.

AMA Style

Burns JR, Zekonyte J, Siligardi G, Hussain R, Stulz E. Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly. Molecules. 2011; 16(6):4912-4922.

Chicago/Turabian Style

Burns, Jonathan R.; Zekonyte, Jurgita; Siligardi, Giuliano; Hussain, Rohanah; Stulz, Eugen. 2011. "Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly." Molecules 16, no. 6: 4912-4922.

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