Molecules 2011, 16(6), 4912-4922; doi:10.3390/molecules16064912

Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly

1 School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK 2 National Centre for Advanced Tribology, School of Engineering Sciences, University of Southampton, Highfield, Southampton, SO17 1BJ, UK 3 Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK
* Author to whom correspondence should be addressed.
Received: 4 May 2011; in revised form: 31 May 2011 / Accepted: 10 June 2011 / Published: 15 June 2011
(This article belongs to the Special Issue Nucleoside Analogues)
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Abstract: We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.
Keywords: terpy-DNA; AFM; TEM; DNA nanotubes

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MDPI and ACS Style

Burns, J.R.; Zekonyte, J.; Siligardi, G.; Hussain, R.; Stulz, E. Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly. Molecules 2011, 16, 4912-4922.

AMA Style

Burns JR, Zekonyte J, Siligardi G, Hussain R, Stulz E. Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly. Molecules. 2011; 16(6):4912-4922.

Chicago/Turabian Style

Burns, Jonathan R.; Zekonyte, Jurgita; Siligardi, Giuliano; Hussain, Rohanah; Stulz, Eugen. 2011. "Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly." Molecules 16, no. 6: 4912-4922.

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