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Molecules 2011, 16(6), 4500-4510; doi:10.3390/molecules16064500

Catalytic Synthesis of α-Oxoketene S,S-Acetals in a Wet Ionic Liquid [Bmim]Cl/H2O Homogeneous System

1
Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China
2
Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China
3
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz 55128, Germany
*
Authors to whom correspondence should be addressed.
Received: 23 March 2011 / Revised: 11 May 2011 / Accepted: 18 May 2011 / Published: 27 May 2011
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Abstract

A clean, practical and environmentally friendly synthesis in a homogeneous system has been developed for α-oxoketene S,S-acetals. A mixture of [Bmim]Cl and water was used as medium. The best economical and practical molar ratio of [Bmim]Cl to substrate was 4 to 1. With various types of 1,3-dicarbonyl compounds as substrate, the corresponding α-oxoketene S,S-acetals have been prepared under mild reaction conditions with yields of 53–74% after purification with silica gel column. [Bmim]Cl/water can be recycled several times.
Keywords: 1,3-dicarbonyl compounds; α-oxoketene S,S-acetals; [Bmim]Cl; water 1,3-dicarbonyl compounds; α-oxoketene S,S-acetals; [Bmim]Cl; water
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MDPI and ACS Style

Yu, P.; Zu, Y.; Fu, Y.; Efferth, T. Catalytic Synthesis of α-Oxoketene S,S-Acetals in a Wet Ionic Liquid [Bmim]Cl/H2O Homogeneous System. Molecules 2011, 16, 4500-4510.

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