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Molecules 2011, 16(6), 4500-4510; doi:10.3390/molecules16064500
Article

Catalytic Synthesis of α-Oxoketene S,S-Acetals in a Wet Ionic Liquid [Bmim]Cl/H2O Homogeneous System

1,2, 1,2,* , 1,2,*  and 3
1 Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China 2 Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China 3 Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz 55128, Germany
* Authors to whom correspondence should be addressed.
Received: 23 March 2011 / Revised: 11 May 2011 / Accepted: 18 May 2011 / Published: 27 May 2011
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Abstract

A clean, practical and environmentally friendly synthesis in a homogeneous system has been developed for α-oxoketene S,S-acetals. A mixture of [Bmim]Cl and water was used as medium. The best economical and practical molar ratio of [Bmim]Cl to substrate was 4 to 1. With various types of 1,3-dicarbonyl compounds as substrate, the corresponding α-oxoketene S,S-acetals have been prepared under mild reaction conditions with yields of 53–74% after purification with silica gel column. [Bmim]Cl/water can be recycled several times.
Keywords: 1,3-dicarbonyl compounds; α-oxoketene S,S-acetals; [Bmim]Cl; water 1,3-dicarbonyl compounds; α-oxoketene S,S-acetals; [Bmim]Cl; water
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yu, P.; Zu, Y.; Fu, Y.; Efferth, T. Catalytic Synthesis of α-Oxoketene S,S-Acetals in a Wet Ionic Liquid [Bmim]Cl/H2O Homogeneous System. Molecules 2011, 16, 4500-4510.

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