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The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis
Working Group of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, CZ-61265 Brno, Czech Republic
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Received: 20 December 2010; in revised form: 4 January 2011 / Accepted: 17 January 2011 / Published: 17 January 2011
Abstract: The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either non-selective activation of adenosine receptors induced by elevation of extracellular adenosine or by administration of synthetic adenosine analogs having various proportions of selectivity for a particular receptor. Numerous studies have described stimulatory effects of non-selective activation of adenosine receptors, manifested as enhancement of proliferation of cells at various levels of the hematopoietic hierarchy. Subsequent experimental approaches, considering the hematopoiesis-modulating action of adenosine receptor agonists with a high level of selectivity to individual adenosine receptor subtypes, have revealed differential effects of various adenosine analogs. Whereas selective activation of A1 receptors has resulted in suppression of proliferation of hematopoietic progenitor and precursor cells, that of A3 receptors has led to stimulated cell proliferation in these cell compartments. Thus, A1 and A3 receptors have been found to play a homeostatic role in suppressed and regenerating hematopoiesis. Selective activation of adenosine A3 receptors has been found to act curatively under conditions of drug- and radiation-induced myelosuppression. The findings in these and further research areas will be summarized and mechanisms of hematopoiesis-modulating action of adenosine receptor agonists will be discussed.
Keywords: adenosine receptors; hematopoiesis; myelosuppression
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Hofer, M.; Pospisil, M.; Weiterova, L.; Hoferova, Z. The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis. Molecules 2011, 16, 675-685.
Hofer M, Pospisil M, Weiterova L, Hoferova Z. The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis. Molecules. 2011; 16(1):675-685.
Hofer, Michal; Pospisil, Milan; Weiterova, Lenka; Hoferova, Zuzana. 2011. "The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis." Molecules 16, no. 1: 675-685.