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Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans
Department of Biomaterials Science, Institute of Dentistry and Biocity Turku Biomaterial Research Program, University of Turku, Turku 20520, Finland
Turku Clinical Biomaterials Centre-TCBC, University of Turku, Turku 20520, Finland
College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
Institute of Dentistry, University of Turku, Turku 20520, Finland
Antimicrobial Resistance Unit, National Institute for Health and Welfare, Turku 20520, Finland
* Author to whom correspondence should be addressed.
Received: 18 October 2011; in revised form: 21 November 2011 / Accepted: 22 November 2011 / Published: 23 November 2011
Abstract: A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, 1H-NMR, and 13C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.
Keywords: dental materials; methacrylate; quaternary ammonium compounds; antibacterial
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MDPI and ACS Style
He, J.; Söderling, E.; Österblad, M.; Vallittu, P.K.; Lassila, L.V.J. Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans. Molecules 2011, 16, 9755-9763.
He J, Söderling E, Österblad M, Vallittu PK, Lassila LVJ. Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans. Molecules. 2011; 16(11):9755-9763.
He, Jingwei; Söderling, Eva; Österblad, Monica; Vallittu, Pekka K.; Lassila, Lippo V. J. 2011. "Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans." Molecules 16, no. 11: 9755-9763.