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Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans
AbstractA series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, 1H-NMR, and 13C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.
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He, J.; Söderling, E.; Österblad, M.; Vallittu, P.K.; Lassila, L.V.J. Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans. Molecules 2011, 16, 9755-9763.View more citation formats
He J, Söderling E, Österblad M, Vallittu PK, Lassila LVJ. Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans. Molecules. 2011; 16(11):9755-9763.Chicago/Turabian Style
He, Jingwei; Söderling, Eva; Österblad, Monica; Vallittu, Pekka K.; Lassila, Lippo V. J. 2011. "Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans." Molecules 16, no. 11: 9755-9763.