Molecules 2011, 16(11), 9755-9763; doi:10.3390/molecules16119755
Article

Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans

1,2,3,* email, 4, 5, 1,2 and 1,2
Received: 18 October 2011; in revised form: 21 November 2011 / Accepted: 22 November 2011 / Published: 23 November 2011
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, 1H-NMR, and 13C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.
Keywords: dental materials; methacrylate; quaternary ammonium compounds; antibacterial
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MDPI and ACS Style

He, J.; Söderling, E.; Österblad, M.; Vallittu, P.K.; Lassila, L.V.J. Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans. Molecules 2011, 16, 9755-9763.

AMA Style

He J, Söderling E, Österblad M, Vallittu PK, Lassila LVJ. Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans. Molecules. 2011; 16(11):9755-9763.

Chicago/Turabian Style

He, Jingwei; Söderling, Eva; Österblad, Monica; Vallittu, Pekka K.; Lassila, Lippo V. J. 2011. "Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans." Molecules 16, no. 11: 9755-9763.

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