Next Article in Journal
Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume
Previous Article in Journal
Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(11), 9755-9763; doi:10.3390/molecules16119755

Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans

1
Department of Biomaterials Science, Institute of Dentistry and Biocity Turku Biomaterial Research Program, University of Turku, Turku 20520, Finland
2
Turku Clinical Biomaterials Centre-TCBC, University of Turku, Turku 20520, Finland
3
College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
4
Institute of Dentistry, University of Turku, Turku 20520, Finland
5
Antimicrobial Resistance Unit, National Institute for Health and Welfare, Turku 20520, Finland
*
Author to whom correspondence should be addressed.
Received: 18 October 2011 / Revised: 21 November 2011 / Accepted: 22 November 2011 / Published: 23 November 2011
(This article belongs to the Section Medicinal Chemistry)
Download PDF [179 KB, uploaded 18 June 2014]

Abstract

A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, 1H-NMR, and 13C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.
Keywords: dental materials; methacrylate; quaternary ammonium compounds; antibacterial dental materials; methacrylate; quaternary ammonium compounds; antibacterial
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

He, J.; Söderling, E.; Österblad, M.; Vallittu, P.K.; Lassila, L.V.J. Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans. Molecules 2011, 16, 9755-9763.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top