Next Article in Journal
Antibacterial Activity of the Flavonoids from Dalbergia odorifera on Ralstonia solanacearum
Previous Article in Journal
Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans
Molecules 2011, 16(11), 9764-9774; doi:10.3390/molecules16119764
Article

Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume

, , , , , , *  and *
Received: 18 October 2011; in revised form: 14 November 2011 / Accepted: 15 November 2011 / Published: 24 November 2011
Download PDF [196 KB, uploaded 18 June 2014]
Abstract: Substantial evidence suggests that phenolic extracts of Castanea mollissima spiny burs (CMPE) increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied in normal and STZ-induced diabetic rats CMPE were orally administrated at doses of 150 and 300 mg/kg twice a day for 12 consecutive days. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels, malondialdehyde (MDA) level and SOD activity in liver, kidney, spleen and heart tissues were measured spectrophotometrically. In normal rats, no significant changes were observed in serum glucose, lipid profiles and tissue MDA and GSH levels after orally administration of CMPE. In diabetic rats, oral administration of CMPE at a dose of 300 mg/kg caused significant decreases in serum glucose, triglyceride, total cholesterol, LDL-cholesterol levels, as well as MDA and GSH levels in spleen and liver tissues. However, the 300 mg/kg dosage caused a significant body weight loss in both normal and diabetic rats. The observed effects indicated that CMPE could be further developed as a drug to prevent abnormal changes in blood glucose and lipid profile and to attenuate lipid peroxidation in liver and spleen tissues.
Keywords: Castanea mollissima; tannins; polyphenols; diabetes; hypoglycemic; hypolipidemic; chestnut burs Castanea mollissima; tannins; polyphenols; diabetes; hypoglycemic; hypolipidemic; chestnut burs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Yin, P.; Zhao, S.; Chen, S.; Liu, J.; Shi, L.; Wang, X.; Liu, Y.; Ma, C. Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume. Molecules 2011, 16, 9764-9774.

AMA Style

Yin P, Zhao S, Chen S, Liu J, Shi L, Wang X, Liu Y, Ma C. Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume. Molecules. 2011; 16(11):9764-9774.

Chicago/Turabian Style

Yin, Peipei; Zhao, Shan; Chen, Siyu; Liu, Jieyuan; Shi, Lingling; Wang, Xinjie; Liu, Yujun; Ma, Chao. 2011. "Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume." Molecules 16, no. 11: 9764-9774.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert