Molecules 2011, 16(11), 9697-9713; doi:10.3390/molecules16119697

Lipase-Catalyzed Kinetic Resolution of Aryltrimethylsilyl Chiral Alcohols

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Received: 27 September 2011; in revised form: 28 October 2011 / Accepted: 17 November 2011 / Published: 23 November 2011
(This article belongs to the Special Issue Organosilicon Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Lipase-catalyzed kinetic resolution of aryltrimethylsilyl chiral alcohols through a transesterification reaction was studied. The optimal conditions found for the kinetic resolution of m- and p-aryltrimethylsilyl chiral alcohols, led to excellent results, high conversions (c = 50%), high enantiomeric ratios (E > 200) and enantiomeric excesses for the remaining (S)-alcohol and (R)-acetylated product (>99%). However, kinetic resolution of o-aryltrimethylsilyl chiral alcohols did not occur under the same conditions applied to the other isomers.
Keywords: lipase; aryltrimethylsilyl chiral alcohols; kinetic resolution; transesterification
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MDPI and ACS Style

Palmeira, D.J.; Abreu, J.C.; Andrade, L.H. Lipase-Catalyzed Kinetic Resolution of Aryltrimethylsilyl Chiral Alcohols. Molecules 2011, 16, 9697-9713.

AMA Style

Palmeira DJ, Abreu JC, Andrade LH. Lipase-Catalyzed Kinetic Resolution of Aryltrimethylsilyl Chiral Alcohols. Molecules. 2011; 16(11):9697-9713.

Chicago/Turabian Style

Palmeira, Dayvson J.; Abreu, Juliana C.; Andrade, Leandro H. 2011. "Lipase-Catalyzed Kinetic Resolution of Aryltrimethylsilyl Chiral Alcohols." Molecules 16, no. 11: 9697-9713.

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