Molecules 2011, 16(11), 9714-9720; doi:10.3390/molecules16119714
Article

Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)

Emmanoel Vilaça Costa 1 email, Maria Lúcia Belém Pinheiro 2,* email, Afonso Duarte Leão de Souza 2 email, Andersson Barison 3 email, Francinete Ramos Campos 4 email, Rodrigo Hinojosa Valdez 5 email, Tânia Ueda-Nakamura 5 email, Benedito Prado Dias Filho 5 email and Celso Vataru Nakamura 5 email
1 LABORGANICS, Department of Chemistry, Federal University of Sergipe, 49100-000, São Cristóvão, SE, Brazil 2 Department of Chemistry, Federal University of Amazonas, 69077-000, Manaus, AM, Brazil 3 Department of Chemistry, Federal University of Paraná, 81531-990, Curitiba, PR, Brazil 4 Department of Pharmacy, Federal University of Paraná, 80210-170, Curitiba, PR, Brazil 5 Department of Basic Health Sciences, State University of Maringá, 87020-900, Maringá, PR, Brazil
* Author to whom correspondence should be addressed.
Received: 13 October 2011; in revised form: 17 November 2011 / Accepted: 17 November 2011 / Published: 23 November 2011
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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Abstract: Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2–4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
Keywords: annonaceae; Annona foetida; alkaloids; oxoaporphine alkaloids; pyrimidine-β-carboline alkaloids; trypanocidal activity

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Cite This Article

MDPI and ACS Style

Costa, E.V.; Pinheiro, M.L.B.; Souza, A.D.L.; Barison, A.; Campos, F.R.; Valdez, R.H.; Ueda-Nakamura, T.; Filho, B.P.D.; Nakamura, C.V. Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae). Molecules 2011, 16, 9714-9720.

AMA Style

Costa EV, Pinheiro MLB, Souza ADL, Barison A, Campos FR, Valdez RH, Ueda-Nakamura T, Filho BPD, Nakamura CV. Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae). Molecules. 2011; 16(11):9714-9720.

Chicago/Turabian Style

Costa, Emmanoel Vilaça; Pinheiro, Maria Lúcia Belém; Souza, Afonso Duarte Leão de; Barison, Andersson; Campos, Francinete Ramos; Valdez, Rodrigo Hinojosa; Ueda-Nakamura, Tânia; Filho, Benedito Prado Dias; Nakamura, Celso Vataru. 2011. "Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)." Molecules 16, no. 11: 9714-9720.

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