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Molecules 2011, 16(11), 9714-9720; doi:10.3390/molecules16119714
Article

Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)

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Received: 13 October 2011; in revised form: 17 November 2011 / Accepted: 17 November 2011 / Published: 23 November 2011
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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Abstract: Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 24 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
Keywords: annonaceae; Annona foetida; alkaloids; oxoaporphine alkaloids; pyrimidine-β-carboline alkaloids; trypanocidal activity annonaceae; Annona foetida; alkaloids; oxoaporphine alkaloids; pyrimidine-β-carboline alkaloids; trypanocidal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Costa, E.V.; Pinheiro, M.L.B.; Souza, A.D.L.; Barison, A.; Campos, F.R.; Valdez, R.H.; Ueda-Nakamura, T.; Filho, B.P.D.; Nakamura, C.V. Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae). Molecules 2011, 16, 9714-9720.

AMA Style

Costa EV, Pinheiro MLB, Souza ADL, Barison A, Campos FR, Valdez RH, Ueda-Nakamura T, Filho BPD, Nakamura CV. Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae). Molecules. 2011; 16(11):9714-9720.

Chicago/Turabian Style

Costa, Emmanoel Vilaça; Pinheiro, Maria Lúcia Belém; Souza, Afonso Duarte Leão de; Barison, Andersson; Campos, Francinete Ramos; Valdez, Rodrigo Hinojosa; Ueda-Nakamura, Tânia; Filho, Benedito Prado Dias; Nakamura, Celso Vataru. 2011. "Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)." Molecules 16, no. 11: 9714-9720.


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