Next Article in Journal
Soulamarin, a New Coumarin from Stem Bark of Calophyllum soulattri
Next Article in Special Issue
Applied Biological and Physicochemical Activity of Isoquinoline Alkaloids: Oxoisoaporphine and Boldine
Previous Article in Journal
Lipase-Catalyzed Kinetic Resolution of Aryltrimethylsilyl Chiral Alcohols
Previous Article in Special Issue
(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(11), 9714-9720; doi:10.3390/molecules16119714

Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)

1
LABORGANICS, Department of Chemistry, Federal University of Sergipe, 49100-000, São Cristóvão, SE, Brazil
2
Department of Chemistry, Federal University of Amazonas, 69077-000, Manaus, AM, Brazil
3
Department of Chemistry, Federal University of Paraná, 81531-990, Curitiba, PR, Brazil
4
Department of Pharmacy, Federal University of Paraná, 80210-170, Curitiba, PR, Brazil
5
Department of Basic Health Sciences, State University of Maringá, 87020-900, Maringá, PR, Brazil
*
Author to whom correspondence should be addressed.
Received: 13 October 2011 / Revised: 17 November 2011 / Accepted: 17 November 2011 / Published: 23 November 2011
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
Download PDF [203 KB, uploaded 18 June 2014]

Abstract

Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 24 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
Keywords: annonaceae; Annona foetida; alkaloids; oxoaporphine alkaloids; pyrimidine-β-carboline alkaloids; trypanocidal activity annonaceae; Annona foetida; alkaloids; oxoaporphine alkaloids; pyrimidine-β-carboline alkaloids; trypanocidal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Costa, E.V.; Pinheiro, M.L.B.; Souza, A.D.L.; Barison, A.; Campos, F.R.; Valdez, R.H.; Ueda-Nakamura, T.; Filho, B.P.D.; Nakamura, C.V. Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae). Molecules 2011, 16, 9714-9720.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top