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Molecules 2011, 16(11), 9714-9720; doi:10.3390/molecules16119714
Article

Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)

1
, 2,* , 2
, 3
, 4
, 5
, 5
, 5
 and 5
1 LABORGANICS, Department of Chemistry, Federal University of Sergipe, 49100-000, São Cristóvão, SE, Brazil 2 Department of Chemistry, Federal University of Amazonas, 69077-000, Manaus, AM, Brazil 3 Department of Chemistry, Federal University of Paraná, 81531-990, Curitiba, PR, Brazil 4 Department of Pharmacy, Federal University of Paraná, 80210-170, Curitiba, PR, Brazil 5 Department of Basic Health Sciences, State University of Maringá, 87020-900, Maringá, PR, Brazil
* Author to whom correspondence should be addressed.
Received: 13 October 2011 / Revised: 17 November 2011 / Accepted: 17 November 2011 / Published: 23 November 2011
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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Abstract

Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH2Cl2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 24 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
Keywords: annonaceae; Annona foetida; alkaloids; oxoaporphine alkaloids; pyrimidine-β-carboline alkaloids; trypanocidal activity annonaceae; Annona foetida; alkaloids; oxoaporphine alkaloids; pyrimidine-β-carboline alkaloids; trypanocidal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Costa, E.V.; Pinheiro, M.L.B.; Souza, A.D.L.; Barison, A.; Campos, F.R.; Valdez, R.H.; Ueda-Nakamura, T.; Filho, B.P.D.; Nakamura, C.V. Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae). Molecules 2011, 16, 9714-9720.

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