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Molecules 2011, 16(11), 9331-9339; doi:10.3390/molecules16119331

Chemical Constituents and Biological Studies of the Leaves of Grevillea robusta

1
School of Pharmacy, China Medical University, Taichung 40402, Taiwan
2
Chinese Medicinal Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan
3
Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan
*
Author to whom correspondence should be addressed.
Received: 8 October 2011 / Revised: 1 November 2011 / Accepted: 3 November 2011 / Published: 7 November 2011
(This article belongs to the Section Natural Products)
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Abstract

Three new compounds: Graviquinone (1), cis-3-hydroxy-5-pentadecylcyclohexanone (2), and methyl 5-ethoxy-2-hydroxycinnamate (3), and thirty-eight known compounds were isolated and identified from the leaves of Grevillea robusta. The structures of these compounds were determined by spectroscopic and chemical transformation methods. Graviquinone (1) showed the strongest cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines. Methyl 2,5-dihydroxycinnamate (4), graviphane (13), and dehydrograviphane (14) exhibited very potent DPPH scavenging activity compared with α-tocopherol. Methyl 2,5-dihydroxycinnamate (4) and bis-norstriatol (17) demonstrated strong inhibition of L-DOPA oxidation by mushroom tyrosinase compared with kojic acid.
Keywords: Grevillea robusta; proteaceae; cytotoxicity; DPPH; tyrosinase inhibition activity Grevillea robusta; proteaceae; cytotoxicity; DPPH; tyrosinase inhibition activity
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Chuang, T.-H.; Chan, H.-H.; Wu, T.-S.; Li, C.-F. Chemical Constituents and Biological Studies of the Leaves of Grevillea robusta. Molecules 2011, 16, 9331-9339.

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