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Molecules 2011, 16(11), 9331-9339; doi:10.3390/molecules16119331
Article

Chemical Constituents and Biological Studies of the Leaves of Grevillea robusta

1,* , 2,3
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 and 1
Received: 8 October 2011; in revised form: 1 November 2011 / Accepted: 3 November 2011 / Published: 7 November 2011
(This article belongs to the Section Metabolites)
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Abstract: Three new compounds: Graviquinone (1), cis-3-hydroxy-5-pentadecylcyclohexanone (2), and methyl 5-ethoxy-2-hydroxycinnamate (3), and thirty-eight known compounds were isolated and identified from the leaves of Grevillea robusta. The structures of these compounds were determined by spectroscopic and chemical transformation methods. Graviquinone (1) showed the strongest cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines. Methyl 2,5-dihydroxycinnamate (4), graviphane (13), and dehydrograviphane (14) exhibited very potent DPPH scavenging activity compared with α-tocopherol. Methyl 2,5-dihydroxycinnamate (4) and bis-norstriatol (17) demonstrated strong inhibition of L-DOPA oxidation by mushroom tyrosinase compared with kojic acid.
Keywords: Grevillea robusta; proteaceae; cytotoxicity; DPPH; tyrosinase inhibition activity Grevillea robusta; proteaceae; cytotoxicity; DPPH; tyrosinase inhibition activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chuang, T.-H.; Chan, H.-H.; Wu, T.-S.; Li, C.-F. Chemical Constituents and Biological Studies of the Leaves of Grevillea robusta. Molecules 2011, 16, 9331-9339.

AMA Style

Chuang T-H, Chan H-H, Wu T-S, Li C-F. Chemical Constituents and Biological Studies of the Leaves of Grevillea robusta. Molecules. 2011; 16(11):9331-9339.

Chicago/Turabian Style

Chuang, Ta-Hsien; Chan, Hsiu-Hui; Wu, Tian-Shung; Li, Chien-Fu. 2011. "Chemical Constituents and Biological Studies of the Leaves of Grevillea robusta." Molecules 16, no. 11: 9331-9339.


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