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Molecules 2011, 16(11), 9274-9297; doi:10.3390/molecules16119274

MAOS and Medicinal Chemistry: Some Important Examples from the Last Years

1
Laboratório de Avaliação e Síntese de substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, PO Box 68023, Rio de Janeiro 21941-902, RJ, Brazil
2
Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, RJ, Brazil
3
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, Seropédica 23890-000, RJ, Brazil
4
Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil
*
Authors to whom correspondence should be addressed.
Received: 16 September 2011 / Revised: 17 October 2011 / Accepted: 26 October 2011 / Published: 7 November 2011
(This article belongs to the Special Issue Microwave Assisted Synthesis)
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Abstract

This review aims to highlight microwave-assisted organic synthesis as applied to medicinal chemistry in the last years, showing some reactions performed under microwave irradiation for the synthesis of distinct structurally molecules of biological interest, divided into the following groups: antineoplastics, anti-inflammatory, antimicrobial agents, antivirals, agents for the treatment of neglected diseases and central nervous system-acting prototypes.
Keywords: microwave irradiation; medicinal chemistry; bioactive compounds; drug discovery microwave irradiation; medicinal chemistry; bioactive compounds; drug discovery
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nascimento-Júnior, N.M.; Kümmerle, A.E.; Barreiro, E.J.; Fraga, C.A.M. MAOS and Medicinal Chemistry: Some Important Examples from the Last Years. Molecules 2011, 16, 9274-9297.

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