Molecules 2011, 16(11), 9298-9315; doi:10.3390/molecules16119298
Article

Effect of the Lectin of Bauhinia variegata and Its Recombinant Isoform on Surgically Induced Skin Wounds in a Murine Model

1email, 2email, 1email, 1email, 4email, 1email, 1email, 3,†email, 5,†email, 3,†email, 4,†email and 1,†,* email
Received: 22 September 2011; in revised form: 20 October 2011 / Accepted: 27 October 2011 / Published: 7 November 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Lectins are a structurally heterogeneous group of highly specific carbohydrate-binding proteins. Due to their great biotechnological potential, lectins are widely used in biomedical research. The purpose of the present study was to evaluate the healing potential of the lectin of Bauhinia variegata (nBVL) and its recombinant isoform (rBVL-1). Following surgical creation of dorsal skin wounds, seven groups of mice were submitted to topical treatment for 12 days with lectin, D-galactose, BSA and saline. The animals were anesthetized and euthanized on POD 2, 7 and 12 in order to evaluate the healing potential of each treatment. The parameters considered included wound size, contraction rate, epithelialization rate and histopathological findings. Wound closure was fastest in animals treated with rBVL-1 (POD 7). nBVL was more effective than the controls. All skin layers were reconstructed and keratin deposition increased. Our findings indicate that the lectin of Bauhinia variegata possesses pro-healing properties and may be employed in the treatment of acute skin wounds.
Keywords: wound healing; legume lectins; Caesalpinoideae; Bauhinia variegata
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MDPI and ACS Style

Neto, L.G.N.; Pinto, L.S.; Bastos, R.M.; Evaristo, F.F.V.; Vasconcelos, M.A.; Carneiro, V.A.; Arruda, F.V.S.; Porto, A.L.F.; Leal, R.B.; Júnior, V.A.S.; Cavada, B.S.; Teixeira, E.H. Effect of the Lectin of Bauhinia variegata and Its Recombinant Isoform on Surgically Induced Skin Wounds in a Murine Model. Molecules 2011, 16, 9298-9315.

AMA Style

Neto LGN, Pinto LS, Bastos RM, Evaristo FFV, Vasconcelos MA, Carneiro VA, Arruda FVS, Porto ALF, Leal RB, Júnior VAS, Cavada BS, Teixeira EH. Effect of the Lectin of Bauhinia variegata and Its Recombinant Isoform on Surgically Induced Skin Wounds in a Murine Model. Molecules. 2011; 16(11):9298-9315.

Chicago/Turabian Style

Neto, Luiz Gonzaga do Nascimento; Pinto, Luciano da Silva; Bastos, Rafaela Mesquita; Evaristo, Francisco Flávio Vasconcelos; Vasconcelos, Mayron Alves de; Carneiro, Victor Alves; Arruda, Francisco Vassiliepe Sousa; Porto, Ana Lúcia Figueiredo; Leal, Rodrigo Bainy; Júnior, Valdemiro Amaro da Silva; Cavada, Benildo Sousa; Teixeira, Edson Holanda. 2011. "Effect of the Lectin of Bauhinia variegata and Its Recombinant Isoform on Surgically Induced Skin Wounds in a Murine Model." Molecules 16, no. 11: 9298-9315.

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