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Molecules 2010, 15(9), 5909-5927; doi:10.3390/molecules15095909

Modular Synthesis of Polyphenolic Benzofurans, and Application in the Total Synthesis of Malibatol A and Shoreaphenol

Chemical Synthesis Laboratory at Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, No. 03-08, 138667, Singapore
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Received: 29 July 2010 / Revised: 26 August 2010 / Accepted: 27 August 2010 / Published: 27 August 2010
(This article belongs to the Special Issue Diversity Oriented Synthesis)
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Abstract

A modular strategy for the synthesis of hexacyclic dimeric resveratrol polyphenolic benzofurans is reported. The developed synthetic technology was applied to the total synthesis of malibatol A, shoreaphenol, and other biologically relevant poly-phenols.
Keywords: cascade reaction; polyphenol; resveratrol; Friedel-Crafts; natural product; total synthesis cascade reaction; polyphenol; resveratrol; Friedel-Crafts; natural product; total synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chen, D.-K.; Kang, Q.; Wu, T.R. Modular Synthesis of Polyphenolic Benzofurans, and Application in the Total Synthesis of Malibatol A and Shoreaphenol. Molecules 2010, 15, 5909-5927.

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