Special Issue "Diversity Oriented Synthesis"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (28 February 2011)
Prof. Dr. Peter Wipf
1301 Chevron Hall, Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA
Phone: +1 412 624 8606
Fax: +1 412 624 0787
Interests: natural product total synthesis; organometallic chemistry; heterocyclic chemistry; combinatorial chemistry; medicinal chemistry
In many ways, Diversity-Oriented Synthesis (DOS) represents the conceptualization and expansion of some long-established research principles in medicinal chemistry and drug discovery. The physicochemical metrics that allow us to evaluate the structural similarity within a set of organic molecules often fall short in capturing the essence of the 3-dimensional array of functional groups that the chemist’s eye looks recognizes. In particular, there is a major discrepancy between theory and utility if these metrics are mainly based on generic descriptors such as molecular weight and logP, which tend to cluster in a narrow range. Research in applying the tools of organic synthesis to the construction of scaffold and stereochemical diversity in small organic molecules has never been so active, benefiting from decades of natural products chemistry and advances in multicomponent and pericyclic reactions, as well as asymmetric catalysis. Many of the resulting new organic products are finding their way into public and industrial high throughput screening programs, and therefore serve to link chemical and biological space.
This Special Issue on Diversity-Oriented Synthesis will offer an attractive forum to present the synthesis, structural and cheminformatics analysis, pharmacology and therapeutic potential offered by new and innovative molecular architectures. I strongly encourage authors to submit papers for this Special Issue on DOS, within the scope of Molecules. I hope that the topics covered will reflect the potential and the excitement of DOS in the chemical community.
Dr. Peter Wipf
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- natural product-like agents
- molecular scaffolds
- stereodivergence and stereoselectivity
- multicomponent reactions
- pericyclic processes
- chemical library synthesis
- diversity analysis
- probe molecules
- biological screening
Article: Modular Synthesis of Polyphenolic Benzofurans, and Application in the Total Synthesis of Malibatol A and Shoreaphenol
Molecules 2010, 15(9), 5909-5927; doi:10.3390/molecules15095909
Received: 29 July 2010; in revised form: 26 August 2010 / Accepted: 27 August 2010 / Published: 27 August 2010| Download PDF Full-text (298 KB)
Article: Synthesis of Lasofoxifene, Nafoxidine and Their Positional Isomers via the Novel Three-Component Coupling Reaction
Molecules 2010, 15(10), 6773-6794; doi:10.3390/molecules15106773
Received: 21 August 2010; in revised form: 13 September 2010 / Accepted: 20 September 2010 / Published: 28 September 2010| Download PDF Full-text (440 KB) | Supplementary Files
Review: Challenges and Perspectives of Chemical Biology, a Successful Multidisciplinary Field of Natural Sciences
Molecules 2011, 16(3), 2672-2687; doi:10.3390/molecules16032672
Received: 9 February 2011; in revised form: 9 March 2011 / Accepted: 15 March 2011 / Published: 23 March 2011| Download PDF Full-text (701 KB)
Review: From Polymer to Small Organic Molecules: A Tight Relationship between Radical Chemistry and Solid-Phase Organic Synthesis
Molecules 2011, 16(4), 3252-3314; doi:10.3390/molecules16043252
Received: 8 March 2011; in revised form: 28 March 2011 / Accepted: 11 April 2011 / Published: 18 April 2011| Download PDF Full-text (688 KB)
Article: Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones Using Oxidative Carbon-Hydrogen Bond Activation and Click Chemistry
Molecules 2011, 16(5), 3648-3662; doi:10.3390/molecules16053648
Received: 9 March 2011 / Accepted: 12 April 2011 / Published: 2 May 2011| Download PDF Full-text (315 KB)
Article: Diversity-Oriented Synthesis Based on the DPPP-Catalyzed Mixed Double-Michael Reactions of Electron-Deficient Acetylenes and β-Amino Alcohols
Molecules 2011, 16(5), 3802-3825; doi:10.3390/molecules16053802
Received: 6 April 2011; in revised form: 29 April 2011 / Accepted: 5 May 2011 / Published: 5 May 2011| Download PDF Full-text (311 KB)
Review: Targeting Oncogenic Protein-Protein Interactions by Diversity Oriented Synthesis and Combinatorial Chemistry Approaches
Molecules 2011, 16(6), 4408-4427; doi:10.3390/molecules16064408
Received: 10 March 2011; in revised form: 4 May 2011 / Accepted: 25 May 2011 / Published: 27 May 2011| Download PDF Full-text (501 KB)
Molecules 2012, 17(11), 13211-13220; doi:10.3390/molecules171113211
Received: 21 September 2012; in revised form: 31 October 2012 / Accepted: 1 November 2012 / Published: 6 November 2012| Download PDF Full-text (763 KB) | Supplementary Files
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Last update: 20 June 2011