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Molecules 2010, 15(9), 5928-5942; doi:10.3390/molecules15095928

An Efficient Procedure Based on a MW-Assisted Horner–Wadsworth-Emmons Reaction for the Synthesis of (Z)-3,3-Trisubstituted-a,b-unsaturated Esters

Dipartimento di Chimica Farmaceutica, viale Taramelli 12, Pavia 27100, Italy
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Received: 28 July 2010 / Revised: 18 August 2010 / Accepted: 25 August 2010 / Published: 27 August 2010
(This article belongs to the Section Organic Synthesis)
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Abstract

A microwave-assisted HWE olefination process of readily accessible aryl-alkyl ketones has been developed to provide a rapid access to (Z)-3,3-trisubstituted-α,β-unsaturated methyl esters, key building blocks for the synthesis of biologically active compounds.
Keywords: (Z)-3,3-trisubstituted α,β-unsaturated methyl esters; aryl-alkyl ketones; Horner–Wadsworth-Emmons reaction; microwave-assisted reactions (Z)-3,3-trisubstituted α,β-unsaturated methyl esters; aryl-alkyl ketones; Horner–Wadsworth-Emmons reaction; microwave-assisted reactions
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Rossi, D.; Baraglia, A.C.; Serra, M.; Azzolina, O.; Collina, S. An Efficient Procedure Based on a MW-Assisted Horner–Wadsworth-Emmons Reaction for the Synthesis of (Z)-3,3-Trisubstituted-a,b-unsaturated Esters. Molecules 2010, 15, 5928-5942.

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