Next Article in Journal
Previous Article in Journal
Molecules 2010, 15(8), 5273-5281; doi:10.3390/molecules15085273
Article

2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance

1,†
, 2,†
 and 3,*
Received: 15 July 2010; in revised form: 27 July 2010 / Accepted: 2 August 2010 / Published: 3 August 2010
Download PDF [335 KB, uploaded 18 June 2014]
Abstract: A natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in murine hepatoma Hepa 1c1c7 cells. Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH).
Keywords: Echinops grijsii hance; PDDYT; NQO1; Nrf2; glutathione; Akt Echinops grijsii hance; PDDYT; NQO1; Nrf2; glutathione; Akt
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Shi, J.; Zhang, X.; Jiang, H. 2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance. Molecules 2010, 15, 5273-5281.

AMA Style

Shi J, Zhang X, Jiang H. 2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance. Molecules. 2010; 15(8):5273-5281.

Chicago/Turabian Style

Shi, Jing; Zhang, Xiaoyu; Jiang, Hai. 2010. "2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance." Molecules 15, no. 8: 5273-5281.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert