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Molecules 2010, 15(6), 4261-4266; doi:10.3390/molecules15064261
Article

Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

1
, 1, 1, 1, 2, 1 and 1,*
Received: 9 April 2010; in revised form: 13 May 2010 / Accepted: 9 June 2010 / Published: 11 June 2010
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Abstract: This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by 1H-NMR, 13C-NMR, MS and the purities of all the compounds were determined by HPLC.
Keywords: bosutinib; protein kinase inhibitors; 3-methoxy-4-hydroxybenzoic acid bosutinib; protein kinase inhibitors; 3-methoxy-4-hydroxybenzoic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yin, X.J.; Xu, G.H.; Sun, X.; Peng, Y.; Ji, X.; Jiang, K.; Li, F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules 2010, 15, 4261-4266.

AMA Style

Yin XJ, Xu GH, Sun X, Peng Y, Ji X, Jiang K, Li F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules. 2010; 15(6):4261-4266.

Chicago/Turabian Style

Yin, Xiao Jia; Xu, Guan Hong; Sun, Xu; Peng, Yan; Ji, Xing; Jiang, Ke; Li, Fei. 2010. "Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid." Molecules 15, no. 6: 4261-4266.


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