Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
AbstractThis paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by 1H-NMR, 13C-NMR, MS and the purities of all the compounds were determined by HPLC.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Yin, X.J.; Xu, G.H.; Sun, X.; Peng, Y.; Ji, X.; Jiang, K.; Li, F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules 2010, 15, 4261-4266.
Yin XJ, Xu GH, Sun X, Peng Y, Ji X, Jiang K, Li F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules. 2010; 15(6):4261-4266.Chicago/Turabian Style
Yin, Xiao Jia; Xu, Guan Hong; Sun, Xu; Peng, Yan; Ji, Xing; Jiang, Ke; Li, Fei. 2010. "Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid." Molecules 15, no. 6: 4261-4266.