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Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
School of Pharmacy, Nanjing Medical University, Nanjing 210029, China
Nanjing Children’s hospital, Nanjing Medical University, Nanjing 210008, China
* Author to whom correspondence should be addressed.
Received: 9 April 2010; in revised form: 13 May 2010 / Accepted: 9 June 2010 / Published: 11 June 2010
Abstract: This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by 1H-NMR, 13C-NMR, MS and the purities of all the compounds were determined by HPLC.
Keywords: bosutinib; protein kinase inhibitors; 3-methoxy-4-hydroxybenzoic acid
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MDPI and ACS Style
Yin, X.J.; Xu, G.H.; Sun, X.; Peng, Y.; Ji, X.; Jiang, K.; Li, F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules 2010, 15, 4261-4266.
Yin XJ, Xu GH, Sun X, Peng Y, Ji X, Jiang K, Li F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules. 2010; 15(6):4261-4266.
Yin, Xiao Jia; Xu, Guan Hong; Sun, Xu; Peng, Yan; Ji, Xing; Jiang, Ke; Li, Fei. 2010. "Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid." Molecules 15, no. 6: 4261-4266.