Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

doi:10.3390/molecules15064261

This article is

freely available
re-usable

Molecules 2010, 15(6), 4261-4266; doi:10.3390/molecules15064261

Article

Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

Xiao Jia Yin¹, Guan Hong Xu¹, Xu Sun¹, Yan Peng¹, Xing Ji², Ke Jiang¹ and Fei Li^1,*

¹ School of Pharmacy, Nanjing Medical University, Nanjing 210029, China ² Nanjing Children’s hospital, Nanjing Medical University, Nanjing 210008, China

* Author to whom correspondence should be addressed.

Received: 9 April 2010; in revised form: 13 May 2010 / Accepted: 9 June 2010 / Published: 11 June 2010

Download PDF Full-Text [94 KB, uploaded 11 June 2010 11:41 CEST]

Abstract: This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by ¹H-NMR, ¹³C-NMR, MS and the purities of all the compounds were determined by HPLC.

Keywords: bosutinib; protein kinase inhibitors; 3-methoxy-4-hydroxybenzoic acid

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Yin, X.J.; Xu, G.H.; Sun, X.; Peng, Y.; Ji, X.; Jiang, K.; Li, F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules 2010, 15, 4261-4266.

AMA Style

Yin XJ, Xu GH, Sun X, Peng Y, Ji X, Jiang K, Li F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules. 2010; 15(6):4261-4266.

Chicago/Turabian Style

Yin, Xiao Jia; Xu, Guan Hong; Sun, Xu; Peng, Yan; Ji, Xing; Jiang, Ke; Li, Fei. 2010. "Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid." Molecules 15, no. 6: 4261-4266.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert