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Molecules 2010, 15(6), 4261-4266; doi:10.3390/molecules15064261

Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

1, 1, 1, 2, 1 and 1,*
1 School of Pharmacy, Nanjing Medical University, Nanjing 210029, China 2 Nanjing Children’s hospital, Nanjing Medical University, Nanjing 210008, China
* Author to whom correspondence should be addressed.
Received: 9 April 2010 / Revised: 13 May 2010 / Accepted: 9 June 2010 / Published: 11 June 2010
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This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by 1H-NMR, 13C-NMR, MS and the purities of all the compounds were determined by HPLC.
Keywords: bosutinib; protein kinase inhibitors; 3-methoxy-4-hydroxybenzoic acid bosutinib; protein kinase inhibitors; 3-methoxy-4-hydroxybenzoic acid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yin, X.J.; Xu, G.H.; Sun, X.; Peng, Y.; Ji, X.; Jiang, K.; Li, F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules 2010, 15, 4261-4266.

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