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Molecules 2010, 15(4), 2651-2666; doi:10.3390/molecules15042651
Article

Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles

1,* , 1, 2, 3 and 3,*
1 Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt 2 Chemistry Department, Faculty of Science, Ibb University, Yemen 3 Laboratoire Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III-CNRS, UMR 6264, Laboratoire Chimie Provence, 27 Bd J. Moulin, 13385 Marseille cedex 5, France
* Authors to whom correspondence should be addressed.
Received: 11 March 2010 / Revised: 31 March 2010 / Accepted: 6 April 2010 / Published: 12 April 2010
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Abstract

The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Other reactions of the latter derivatives leading to pyrido[4',3':4,5]thieno[2,3-d]triazolo[1,5-a]pyrimidines are also presented.
Keywords: pyrimidines; pyridines; thienopyrimidines; fused pyrimidines; fused pyridines pyrimidines; pyridines; thienopyrimidines; fused pyrimidines; fused pyridines
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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El-Kashef, H.; Farghaly, A.-R.; Al-Hazmi, A.; Terme, T.; Vanelle, P. Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles. Molecules 2010, 15, 2651-2666.

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