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Molecules 2010, 15(4), 2651-2666; doi:10.3390/molecules15042651
Article

Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles

1,* , 1, 2, 3 and 3,*
1 Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt 2 Chemistry Department, Faculty of Science, Ibb University, Yemen 3 Laboratoire Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III-CNRS, UMR 6264, Laboratoire Chimie Provence, 27 Bd J. Moulin, 13385 Marseille cedex 5, France
* Authors to whom correspondence should be addressed.
Received: 11 March 2010 / Revised: 31 March 2010 / Accepted: 6 April 2010 / Published: 12 April 2010
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Abstract

The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Other reactions of the latter derivatives leading to pyrido[4',3':4,5]thieno[2,3-d]triazolo[1,5-a]pyrimidines are also presented.
Keywords: pyrimidines; pyridines; thienopyrimidines; fused pyrimidines; fused pyridines pyrimidines; pyridines; thienopyrimidines; fused pyrimidines; fused pyridines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

El-Kashef, H.; Farghaly, A.-R.; Al-Hazmi, A.; Terme, T.; Vanelle, P. Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles. Molecules 2010, 15, 2651-2666.

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