Molecules 2010, 15(3), 1223-1231; doi:10.3390/molecules15031223
Article

Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

1 Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 2 Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 3 Department of Pharmaceutical Sciences, University of Padua, Padua, Italy 4 Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 5 Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czech Republic 6 Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 14 January 2010; in revised form: 5 February 2010 / Accepted: 1 March 2010 / Published: 3 March 2010
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Abstract: The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.
Keywords: Schisandra chinensis; dibenzocyclooctadiene lignans; antiradical; diabetes mellitus

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MDPI and ACS Style

Šmejkal, K.; Šlapetová, T.; Krmenčík, P.; Kubínová, R.; Suchý, P.; Dall´Acqua, S.; Innocenti, G.; Vančo, J.; Kalvarová, K.; Dvorská, M.; Slanina, J.; Kramářová, E.; Muselík, J.; Žemlička, M. Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models. Molecules 2010, 15, 1223-1231.

AMA Style

Šmejkal K, Šlapetová T, Krmenčík P, Kubínová R, Suchý P, Dall´Acqua S, Innocenti G, Vančo J, Kalvarová K, Dvorská M, Slanina J, Kramářová E, Muselík J, Žemlička M. Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models. Molecules. 2010; 15(3):1223-1231.

Chicago/Turabian Style

Šmejkal, Karel; Šlapetová, Tereza; Krmenčík, Pavel; Kubínová, Renata; Suchý, Pavel; Dall´Acqua, Stefano; Innocenti, Gabbriella; Vančo, Ján; Kalvarová, Karolína; Dvorská, Margita; Slanina, Jiří; Kramářová, Eva; Muselík, Jan; Žemlička, Milan. 2010. "Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models." Molecules 15, no. 3: 1223-1231.

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