Molecules 2010, 15(3), 1223-1231; doi:10.3390/molecules15031223
Article

Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

Karel Šmejkal 1,* email, Tereza Šlapetová 1 , Pavel Krmenčík 1 , Renata Kubínová 1 , Pavel Suchý 2 , Stefano Dall´Acqua 3 , Gabbriella Innocenti 3 , Ján Vančo 4 , Karolína Kalvarová 1 , Margita Dvorská 1 , Jiří Slanina 5 , Eva Kramářová 1 , Jan Muselík 6  and Milan Žemlička 1
1 Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 2 Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 3 Department of Pharmaceutical Sciences, University of Padua, Padua, Italy 4 Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 5 Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czech Republic 6 Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 14 January 2010; in revised form: 5 February 2010 / Accepted: 1 March 2010 / Published: 3 March 2010
PDF Full-text Download PDF Full-Text [178 KB, uploaded 3 March 2010 10:39 CET]
Abstract: The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.
Keywords: Schisandra chinensis; dibenzocyclooctadiene lignans; antiradical; diabetes mellitus

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Šmejkal, K.; Šlapetová, T.; Krmenčík, P.; Kubínová, R.; Suchý, P.; Dall´Acqua, S.; Innocenti, G.; Vančo, J.; Kalvarová, K.; Dvorská, M.; Slanina, J.; Kramářová, E.; Muselík, J.; Žemlička, M. Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models. Molecules 2010, 15, 1223-1231.

AMA Style

Šmejkal K, Šlapetová T, Krmenčík P, Kubínová R, Suchý P, Dall´Acqua S, Innocenti G, Vančo J, Kalvarová K, Dvorská M, Slanina J, Kramářová E, Muselík J, Žemlička M. Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models. Molecules. 2010; 15(3):1223-1231.

Chicago/Turabian Style

Šmejkal, Karel; Šlapetová, Tereza; Krmenčík, Pavel; Kubínová, Renata; Suchý, Pavel; Dall´Acqua, Stefano; Innocenti, Gabbriella; Vančo, Ján; Kalvarová, Karolína; Dvorská, Margita; Slanina, Jiří; Kramářová, Eva; Muselík, Jan; Žemlička, Milan. 2010. "Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models." Molecules 15, no. 3: 1223-1231.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert