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Molecules 2010, 15(3), 1223-1231; doi:10.3390/molecules15031223
Article

Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

1,* , 1, 1, 1, 2, 3, 3, 4, 1, 1, 5, 1, 6 and 1
1 Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 2 Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 3 Department of Pharmaceutical Sciences, University of Padua, Padua, Italy 4 Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic 5 Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czech Republic 6 Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 14 January 2010 / Revised: 5 February 2010 / Accepted: 1 March 2010 / Published: 3 March 2010
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Abstract

The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.
Keywords: Schisandra chinensis; dibenzocyclooctadiene lignans; antiradical; diabetes mellitus Schisandra chinensis; dibenzocyclooctadiene lignans; antiradical; diabetes mellitus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Šmejkal, K.; Šlapetová, T.; Krmenčík, P.; Kubínová, R.; Suchý, P.; Dall´Acqua, S.; Innocenti, G.; Vančo, J.; Kalvarová, K.; Dvorská, M.; Slanina, J.; Kramářová, E.; Muselík, J.; Žemlička, M. Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models. Molecules 2010, 15, 1223-1231.

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