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Molecules 2010, 15(3), 1223-1231; doi:10.3390/molecules15031223
Article

Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

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Received: 14 January 2010 / Revised: 5 February 2010 / Accepted: 1 March 2010 / Published: 3 March 2010
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Abstract

The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.
Keywords: Schisandra chinensis; dibenzocyclooctadiene lignans; antiradical; diabetes mellitus Schisandra chinensis; dibenzocyclooctadiene lignans; antiradical; diabetes mellitus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Šmejkal, K.; Šlapetová, T.; Krmenčík, P.; Kubínová, R.; Suchý, P.; Dall´Acqua, S.; Innocenti, G.; Vančo, J.; Kalvarová, K.; Dvorská, M.; Slanina, J.; Kramářová, E.; Muselík, J.; Žemlička, M. Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models. Molecules 2010, 15, 1223-1231.

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