Molecules 2010, 15(6), 4283-4293; doi:10.3390/molecules15064283
Article

Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?

1 Laboratory of Organic Chemistry, Faculty of Sciences, University of Mons-UMONS, 20 place du parc, B-7000 Mons, Belgium 2 Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, 1 Drexel drive, New Orleans, LA 70125, USA 3 Department of Parasitology-Mycology, Faculty of Biological and Pharmaceutical Sciences, University of Lille Nord de France, Lille, France 4 Department of Parasitology-Mycology, Faculty of Medicine, University of Lille Nord de France, Biology-Pathology Centre, University Hospital Center, Lille, France 5 Biology and Diversity of Emergent Eukaryotic Pathogens (BDEEP) (EA3609), IFR142, Institut Pasteur de Lille, Lille, France
* Author to whom correspondence should be addressed.
Received: 26 May 2010; in revised form: 1 June 2010 / Accepted: 7 June 2010 / Published: 11 June 2010
(This article belongs to the Special Issue ECSOC-13)
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Abstract: A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 µg/mL of 87% and 96%, respectively. Those compounds remained active at 0.1 µg/mL.
Keywords: pentamidine; Pneumocystis carinii; monobenzamidines

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MDPI and ACS Style

Laurent, J.; Stanicki, D.; Huang, T.L.; Dei-Cas, E.; Pottier, M.; Aliouat, E.M.; Vanden Eynde, J.J. Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity? Molecules 2010, 15, 4283-4293.

AMA Style

Laurent J, Stanicki D, Huang TL, Dei-Cas E, Pottier M, Aliouat EM, Vanden Eynde JJ. Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity? Molecules. 2010; 15(6):4283-4293.

Chicago/Turabian Style

Laurent, Julien; Stanicki, Dimitri; Huang, Tien L.; Dei-Cas, Eduardo; Pottier, Muriel; Aliouat, El Mouktar; Vanden Eynde, Jean Jacques. 2010. "Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?" Molecules 15, no. 6: 4283-4293.

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