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Molecules 2010, 15(6), 4283-4293; doi:10.3390/molecules15064283
Article

Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?

1, 1, 2, 3,4,5, 3,5, 3,5 and 1,*
Received: 26 May 2010; in revised form: 1 June 2010 / Accepted: 7 June 2010 / Published: 11 June 2010
(This article belongs to the Special Issue ECSOC-13)
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Abstract: A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 µg/mL of 87% and 96%, respectively. Those compounds remained active at 0.1 µg/mL.
Keywords: pentamidine; Pneumocystis carinii; monobenzamidines pentamidine; Pneumocystis carinii; monobenzamidines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Laurent, J.; Stanicki, D.; Huang, T.L.; Dei-Cas, E.; Pottier, M.; Aliouat, E.M.; Vanden Eynde, J.J. Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity? Molecules 2010, 15, 4283-4293.

AMA Style

Laurent J, Stanicki D, Huang TL, Dei-Cas E, Pottier M, Aliouat EM, Vanden Eynde JJ. Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity? Molecules. 2010; 15(6):4283-4293.

Chicago/Turabian Style

Laurent, Julien; Stanicki, Dimitri; Huang, Tien L.; Dei-Cas, Eduardo; Pottier, Muriel; Aliouat, El Mouktar; Vanden Eynde, Jean Jacques. 2010. "Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?" Molecules 15, no. 6: 4283-4293.


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