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Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis
United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202-9034, USA
Received: 30 January 2009; in revised form: 15 February 2009 / Accepted: 20 March 2009 / Published: 23 March 2009
Abstract: Selenium is an essential trace element for humans and animals, and selenium deficiency is associated with several disease conditions such as immune impairment. In addition, selenium intakes that are greater than the recommended daily allowance (RDA) appear to protect against certain types of cancers. In humans and animals, cell proliferation and death must be regulated to maintain tissue homeostasis, and it has been well documented that numerous human diseases are directly related to the control of cell cycle progression and apoptosis. Thus, the elucidation of the mechanisms by which selenium regulates the cell cycle and apoptosis can lead to a better understanding of the nature of selenium’s essentiality and its role in disease prevention. This article reviews the status of knowledge concerning the effect of selenium on cell cycle and apoptosis
Keywords: Selenium; Cell proliferation; Cell cycle; Apoptosis; Cancer
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Zeng, H. Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis. Molecules 2009, 14, 1263-1278.
Zeng H. Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis. Molecules. 2009; 14(3):1263-1278.
Zeng, Huawei. 2009. "Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis." Molecules 14, no. 3: 1263-1278.