Next Article in Journal
A New Synthetic Compound, 2-OH, Enhances Interleukin-2 and Interferon-γ Gene Expression in Human Peripheral Blood Mononuclear Cells
Next Article in Special Issue
Diaroyl Tellurides: Synthesis, Structure and NBO Analysis of (2-MeOC6H4CO)2Te – Comparison with Its Sulfur and Selenium Isologues. The First Observation of [MgBr][R(C=Te)O] Salts
Previous Article in Journal
Pentavalent Antimonials: New Perspectives for Old Drugs
Previous Article in Special Issue
Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis
Article Menu

Export Article

Open AccessReview
Molecules 2009, 14(7), 2337-2344; https://doi.org/10.3390/molecules14072337

Selenium and the Methionine Sulfoxide Reductase System

Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
*
Author to whom correspondence should be addressed.
Received: 12 June 2009 / Revised: 26 June 2009 / Accepted: 30 June 2009 / Published: 1 July 2009
(This article belongs to the Special Issue Selenium and Tellurium Chemistry)
View Full-Text   |   Download PDF [54 KB, uploaded 18 June 2014]   |  

Abstract

Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA-/-), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA-/- mice are presented and discussed. View Full-Text
Keywords: selenoprotein; methionine sulfoxide; oxidative stress; antioxidants; posttranslational modification selenoprotein; methionine sulfoxide; oxidative stress; antioxidants; posttranslational modification
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Oien, D.B.; Moskovitz, J. Selenium and the Methionine Sulfoxide Reductase System. Molecules 2009, 14, 2337-2344.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top