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Molecules 2009, 14(7), 2337-2344;

Selenium and the Methionine Sulfoxide Reductase System

Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
Author to whom correspondence should be addressed.
Received: 12 June 2009 / Revised: 26 June 2009 / Accepted: 30 June 2009 / Published: 1 July 2009
(This article belongs to the Special Issue Selenium and Tellurium Chemistry)
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Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA-/-), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA-/- mice are presented and discussed. View Full-Text
Keywords: selenoprotein; methionine sulfoxide; oxidative stress; antioxidants; posttranslational modification selenoprotein; methionine sulfoxide; oxidative stress; antioxidants; posttranslational modification

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Oien, D.B.; Moskovitz, J. Selenium and the Methionine Sulfoxide Reductase System. Molecules 2009, 14, 2337-2344.

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