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Molecules 2009, 14(9), 3621-3661; doi:10.3390/molecules14093621
Review

Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues

*  and *
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan
* Authors to whom correspondence should be addressed.
Received: 4 August 2009 / Revised: 31 August 2009 / Accepted: 11 September 2009 / Published: 17 September 2009
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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Abstract

Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues.
Keywords: Annonaceous acetogenins; antitumor activity; analogues; structure–activity relationship; polyketides Annonaceous acetogenins; antitumor activity; analogues; structure–activity relationship; polyketides
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kojima, N.; Tanaka, T. Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues. Molecules 2009, 14, 3621-3661.

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