Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues

doi:10.3390/molecules14093621

This article is

freely available
re-usable

Molecules 2009, 14(9), 3621-3661; doi:10.3390/molecules14093621

Review

Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues

Naoto Kojima* and Tetsuaki Tanaka*

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan

* Authors to whom correspondence should be addressed.

Received: 4 August 2009; in revised form: 31 August 2009 / Accepted: 11 September 2009 / Published: 17 September 2009

(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)

Download PDF Full-Text [2839 KB, uploaded 17 September 2009 07:50 CEST]

Abstract: Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues.

Keywords: Annonaceous acetogenins; antitumor activity; analogues; structure–activity relationship; polyketides

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Kojima, N.; Tanaka, T. Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues. Molecules 2009, 14, 3621-3661.

AMA Style

Kojima N, Tanaka T. Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues. Molecules. 2009; 14(9):3621-3661.

Chicago/Turabian Style

Kojima, Naoto; Tanaka, Tetsuaki. 2009. "Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues." Molecules 14, no. 9: 3621-3661.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert