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Molecules 2009, 14(9), 3621-3661; doi:10.3390/molecules14093621
Review

Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues

*  and *
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan
* Authors to whom correspondence should be addressed.
Received: 4 August 2009 / Revised: 31 August 2009 / Accepted: 11 September 2009 / Published: 17 September 2009
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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Abstract

Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues.
Keywords: Annonaceous acetogenins; antitumor activity; analogues; structure–activity relationship; polyketides Annonaceous acetogenins; antitumor activity; analogues; structure–activity relationship; polyketides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kojima, N.; Tanaka, T. Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues. Molecules 2009, 14, 3621-3661.

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