Molecules 2007, 12(11), 2559-2566; doi:10.3390/12112559
Article

The Drug Release Profile from Calcium-induced Alginate Gel Beads Coated with an Alginate Hydrolysate

1,* email, 1, 2, 1, 1 and 1
Received: 17 November 2007; in revised form: 27 November 2007 / Accepted: 27 November 2007 / Published: 29 November 2007
(This article belongs to the collection Prodrugs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Calcium-induced alginate gel bead (Alg-Ca) coated with an alginate hydrolysate(Alg), e.g. the guluronic acid block (GB) was prepared and the model drug, hydrocortisonerelease profiles were investigated under simulated gastrointestinal conditions. Theirmolecular weights were one sixth or one tenth that of Alg and the diffraction patterns of thehydrolysates resembled that of Alg. The drug release rate from Alg-Ca coated with GBapparently lowered than that of Alg-Ca (coating-free) in the gastric juice (pH1.2). And thecoating did not resist the disintegration of Alg-Ca in the intestinal juice (pH 6.8) and thegel erosion accelerated the drug release. On the other hand, for the coated Alg-Cacontaining chitosan, the drug release showed zero-order kinetics without rapid erosion ofAlg-Ca. The drug release rate from Alg-Ca was able to be controlled by the coating andmodifying the composition of the gel matrix.
Keywords: Alginate hydrolysate; Alginate gel bead; Gel bead coating; Drug release profile.
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MDPI and ACS Style

Murata, Y.; Jinno, D.; Liu, D.; Isobe, T.; Kofuji, K.; Kawashima, S. The Drug Release Profile from Calcium-induced Alginate Gel Beads Coated with an Alginate Hydrolysate. Molecules 2007, 12, 2559-2566.

AMA Style

Murata Y, Jinno D, Liu D, Isobe T, Kofuji K, Kawashima S. The Drug Release Profile from Calcium-induced Alginate Gel Beads Coated with an Alginate Hydrolysate. Molecules. 2007; 12(11):2559-2566.

Chicago/Turabian Style

Murata, Yoshifumi; Jinno, Daisaku; Liu, Dongchun; Isobe, Takshi; Kofuji, Kyouko; Kawashima, Susumu. 2007. "The Drug Release Profile from Calcium-induced Alginate Gel Beads Coated with an Alginate Hydrolysate." Molecules 12, no. 11: 2559-2566.

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