Molecular Diagnosis and Risk Assessment of Helminth Infections

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Neglected and Emerging Tropical Diseases".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 542

Special Issue Editors

Section of Pediatric Tropical Medicine, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA
Interests: helminth; soil-transmitted nematode; vaccine; parasitology; immunology; molecular biology
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Guest Editor
Department of Pediatrics, Section of Tropical Medicine, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Interests: helminth, protozoa, diagnostics; environmental testing

Special Issue Information

Dear Colleagues,

Helminth infections are the most common infections in humans, affecting billions of poor people in tropical and subtropical countries, with major public health issues and burdens. Helminth infections cause considerable morbidity in children, with negative impacts on their cognitive development and physical growth. Poor sanitation and limited access to clean drinking water are the significant risks of helminth infections; however, as the world economy grows, we face different risk factors, such as urbanization, globalization, labor workers, and war refugee migration, that may impact helminth infections.  The most effective way to control worm infections and reduce morbidity is mass administration of anti-helminthic drugs for school children. Successful treatments and population-based studies depend on diagnostic techniques with high accuracy. The lack of reliable molecular diagnostic tools to assess the infectious status with high sensitivity and specificity, especially for those with a low intensity of infection and population-based studies, is a major challenge for controlling worm infections. Therefore, the development of molecular diagnoses and risk assessments of helminth infections are urgently needed.

Dr. Bin Zhan
Dr. Rojelio Mejia
Guest Editors

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Keywords

  • helminth
  • infection
  • deworming
  • diagnosis
  • risk assessment
  • molecular diagnostic techniques

Published Papers (1 paper)

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Research

9 pages, 2260 KiB  
Article
IL-33 Enhances the Total Production of IgG, IgG1, and IgG3 in Angiostrongylus cantonensis-Infected Mice
by Po-An Su, Ming-Chieh Ma, Wen-Bin Wu, Jiun-Jr Wang and Wen-Yuan Du
Trop. Med. Infect. Dis. 2024, 9(5), 111; https://doi.org/10.3390/tropicalmed9050111 - 12 May 2024
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Abstract
The purpose of this study is to clarify the role of IL-33 in the immune response to angiostrongyliasis, especially in terms of antibody production and isotype switching. In our experiment, C57BL/6 mice were each infected with 35 infectious larvae and were divided into [...] Read more.
The purpose of this study is to clarify the role of IL-33 in the immune response to angiostrongyliasis, especially in terms of antibody production and isotype switching. In our experiment, C57BL/6 mice were each infected with 35 infectious larvae and were divided into groups that received an intraperitoneal injection of IL-33, anti-IL-33 monoclonal antibody (mAb), or anti-ST2 mAb 3 days post-infection (dpi) and were subsequently administered booster shots at 5-day intervals with the same dose. Serum samples from each group were collected weekly for ELISA assays. The levels of total IgG, IgG1, and IgG3 were significantly increased in A. cantonensis-infected mice that were treated with IL-33, and the levels decreased significantly in infected groups treated with anti-IL-33 or anti-ST2 mAb. These results suggest that IL-33 may play a critical role in the pathogenesis of human angiostrongyliasis and could be useful for understanding protective immunity against this parasitic infection. Full article
(This article belongs to the Special Issue Molecular Diagnosis and Risk Assessment of Helminth Infections)
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