E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Can Botanical Toxins Enhance Human Health?"

Quicklinks

A special issue of Toxins (ISSN 2072-6651).

Deadline for manuscript submissions: closed (31 January 2010)

Special Issue Editor

Guest Editor
Dr. Mark P. Mattson

Laboratory of Neurosciences, National Institute on Aging, Laboratory of Neurosciences, NIA Biomedical Research Center, Room 05C214, 251 Bayview Blvd. Baltimore, MD 21224, USA
Website | E-Mail
Fax: +1 410 558 8465
Interests: oxidative stress and calcium regulation; apoptosis (programmed cell death); neuroprotective signal transduction; synaptic signaling and plasticity; genetic aberrancies and neurodegeneration; diet and neuronal vulnerability; neuroendocrine and neuroimmune mechanisms

Special Issue Information

Dear Colleagues,

Plants, or fungi and bacteria living in or on plants, produce chemicals that function as natural pesticides to dissuade insects and other organisms from damaging the plant. Such "botanical pesticides" (BPs) are often concentrated in the most vulnerable and reproductively essential parts of the plant including the skin of fruits and the buds of vegetables. The structures of BPs vary considerably and include terpenoids, alkaloids, flavonoids, aldehydes, sulphides and limonoids. Human diets include BPs, with the amounts and types of BPs consumed being greater for vegetarians and those who eat organic produce. The purpose of this special issue of TOXINS is to describe evidence suggesting that at least some BPs may be responsible for health benefits of fruits, vegetables and herbal preparations. BPs may exert their beneficial effects by activating adaptive cellular stress response pathways, resulting in increased production of cytoprotective proteins including antioxidant enzymes, detoxifying enzymes and protein chaperones. Animals have evolved metabolic pathways that detoxify BPs, and so the "toxic" effect of the BPs is typically transient and mild. In contrast, man-made pesticides may not be metabolized and so accumulate in amounts that may damage cells and cause disease. The authors provide mini-reviews and their own perspectives on this issue including coverage of evolutionary considerations and the concept of "hormesis", BP structures and biological activities, examples of health benefits of specific BPs, cellular signal transduction mechanisms of BPs in mammals, and a consideration of BP metabolism. Finally, articles in this special issue of TOXINS consider the implications of research on BPs for drug discovery, and the prevention and treatment of human diseases.

Mark P. Mattson, Ph. D.
Guest Editor

Keywords

  • alkaloids
  • antioxidant enzymes
  • evolution; flavonoids
  • hormesis
  • organic vegetables and fruits
  • pest resistance
  • terpenoids

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Review

Open AccessReview Biological Profile of Erucin: A New Promising Anticancer Agent from Cruciferous Vegetables
Toxins 2010, 2(4), 593-612; doi:10.3390/toxins2040593
Received: 9 February 2010 / Revised: 16 March 2010 / Accepted: 30 March 2010 / Published: 5 April 2010
Cited by 29 | PDF Full-text (546 KB) | HTML Full-text | XML Full-text
Abstract
Consumption of cruciferous vegetables has been associated with a reduced risk in the development of various types of cancer. This has been attributed to the bioactive hydrolysis products that are derived from these vegetables, namely isothiocyanates. Erucin is one such product derived from
[...] Read more.
Consumption of cruciferous vegetables has been associated with a reduced risk in the development of various types of cancer. This has been attributed to the bioactive hydrolysis products that are derived from these vegetables, namely isothiocyanates. Erucin is one such product derived from rocket salads, which is structurally related to sulforaphane, a well-studied broccoli-derived isothiocyanate. In this review, we present current knowledge on mechanisms of action of erucin in chemoprevention obtained from cell and animal models and relate it to other isothiocyanates. These mechanisms include modulation of phase I, II and III detoxification, regulation of cell growth by induction of apoptosis and cell cycle arrest, induction of ROS-mechanisms and regulation androgen receptor pathways. Full article
(This article belongs to the Special Issue Can Botanical Toxins Enhance Human Health?)

Journal Contact

MDPI AG
Toxins Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
toxins@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
Editorial Board
Contact Details Submit to Toxins
Back to Top