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Biological Profile of Erucin: A New Promising Anticancer Agent from Cruciferous Vegetables
Foundation “Prof. Antonio Imbesi”, Pharmaco-Biological Department, School of Pharmacy, University of Messina/Villaggio Annunziata, 98168 Messina, Italy
Plant Natural Products and Health Programme, Institute of Food Research/Norwich Research Park, NR4 7UA Norwich, United Kingdom
* Author to whom correspondence should be addressed.
Received: 9 February 2010; in revised form: 16 March 2010 / Accepted: 30 March 2010 / Published: 5 April 2010
Abstract: Consumption of cruciferous vegetables has been associated with a reduced risk in the development of various types of cancer. This has been attributed to the bioactive hydrolysis products that are derived from these vegetables, namely isothiocyanates. Erucin is one such product derived from rocket salads, which is structurally related to sulforaphane, a well-studied broccoli-derived isothiocyanate. In this review, we present current knowledge on mechanisms of action of erucin in chemoprevention obtained from cell and animal models and relate it to other isothiocyanates. These mechanisms include modulation of phase I, II and III detoxification, regulation of cell growth by induction of apoptosis and cell cycle arrest, induction of ROS-mechanisms and regulation androgen receptor pathways.
Keywords: anticancer agents; isothiocyanates; erucin; rocket salads
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Melchini, A.; Traka, M.H. Biological Profile of Erucin: A New Promising Anticancer Agent from Cruciferous Vegetables. Toxins 2010, 2, 593-612.
Melchini A, Traka MH. Biological Profile of Erucin: A New Promising Anticancer Agent from Cruciferous Vegetables. Toxins. 2010; 2(4):593-612.
Melchini, Antonietta; Traka, Maria H. 2010. "Biological Profile of Erucin: A New Promising Anticancer Agent from Cruciferous Vegetables." Toxins 2, no. 4: 593-612.