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Microfluidic Sensors for Biomedical Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biomedical Sensors".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 2648

Special Issue Editor


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Guest Editor
College of Engineering and Computer Science, The University of Texas Rio Grande Valley, Edinburg, TX, USA
Interests: micro/nano-fluidics; bio-sensors and MEMS/NEMS biomedical devices

Special Issue Information

Dear Colleagues,

As the world becomes increasingly concerned with biomolecular disruptor activity, and since the threat of bio pollutants/bioterrorism can be substantially mitigated if detected early, the demand for real-time/on-site detection of bioparticle is expanding quickly. However, current technology is expensive, technically complicated and not portable/compact to use at the contamination sites. So there is a need to develop a robust, rapid lab-on-a-chip (LOC) for detecting bioparticles. This journal covers a multidisciplinary research topics that include, Micro-total-analysis systems (MicroTAS) and lab-on-a-chip applications for biomedical devices; transport in biological and molecular systems; wearable biosensor utilizing the microfluidics devices, Electrokinetic, electrohydrodynamic, and magnetohydrodynamic for biomedical applications; Micro- and nanoscale biomedical devices; Biologically enabled microfluidics; and Sensors and transducers for interdisciplinary applications.

Prof. Dr. Nazmul Islam
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical sensors
  • biologically enable microfluidics
  • wearable biosensors
  • biochemical sensing
  • micro- and nanofluidic bio sensors
  • BioMEMS devices and systems
  • transport in biological and molecular systems
  • biologically enabled microfluidic

Published Papers (1 paper)

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Research

17 pages, 3420 KiB  
Article
A Facile Graphene Conductive Polymer Paper Based Biosensor for Dopamine, TNF-α, and IL-6 Detection
by Md Ashiqur Rahman, Ramendra Kishor Pal, Nazmul Islam, Robert Freeman, Francois Berthiaume, Aaron Mazzeo and Ali Ashraf
Sensors 2023, 23(19), 8115; https://doi.org/10.3390/s23198115 - 27 Sep 2023
Cited by 2 | Viewed by 2384
Abstract
Paper-based biosensors are a potential paradigm of sensitivity achieved via microporous spreading/microfluidics, simplicity, and affordability. In this paper, we develop decorated paper with graphene and conductive polymer (herein referred to as graphene conductive polymer paper-based sensor or GCPPS) for sensitive detection of biomolecules. [...] Read more.
Paper-based biosensors are a potential paradigm of sensitivity achieved via microporous spreading/microfluidics, simplicity, and affordability. In this paper, we develop decorated paper with graphene and conductive polymer (herein referred to as graphene conductive polymer paper-based sensor or GCPPS) for sensitive detection of biomolecules. Planetary mixing resulted in uniformly dispersed graphene and conductive polymer ink, which was applied to laser-cut Whatman filter paper substrates. Scanning electron microscopy and Raman spectroscopy showed strong attachment of conductive polymer-functionalized graphene to cellulose fibers. The GCPPS detected dopamine and cytokines, such as tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) in the ranges of 12.5–400 µM, 0.005–50 ng/mL, and 2 pg/mL–2 µg/mL, respectively, using a minute sample volume of 2 µL. The electrodes showed lower detection limits (LODs) of 3.4 µM, 5.97 pg/mL, and 9.55 pg/mL for dopamine, TNF-α, and IL-6 respectively, which are promising for rapid and easy analysis for biomarkers detection. Additionally, these paper-based biosensors were highly selective (no serpin A1 detection with IL-6 antibody) and were able to detect IL-6 antigen in human serum with high sensitivity and hence, the portable, adaptable, point-of-care, quick, minute sample requirement offered by our fabricated biosensor is advantageous to healthcare applications. Full article
(This article belongs to the Special Issue Microfluidic Sensors for Biomedical Applications)
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