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Microorganisms
Special Issues
Microbiology of Oral Diseases 2.0
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Microbiology of Oral Diseases 2.0

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 3471

Special Issue Editor

Dr. David R. Drake

E-Mail Website
Guest Editor
Iowa Institute for Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
Interests: development of the oral microbiome and role in oral diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous special issue "Microbiology of Oral Diseases".

The composition and activities of the oral microbiome play a foundational role in health and disease within the oral cavity and beyond. This Special Issue is dedicated to the breadth of research focusing on how variables such as microbial properties, host genetics, cell biology, and immunology interact with environmental influences to maintain or disrupt the healthy balance between the host and resident microflora in oral.

Dr. David R. Drake
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral microbiome
  • dental diseases
  • dental caries
  • periodontitis oral cancer
  • oral microbiology
  • oral pathogens
  • host genetics
  • immunology
  • nutrition dysbiosis
  • oral hygiene

Published Papers (1 paper)

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Review

47 pages, 4052 KiB  
Review
The Evolving Microbiome of Dental Caries
by Grace Spatafora, Yihong Li, Xuesong He, Annie Cowan and Anne C. R. Tanner
Microorganisms 2024, 12(1), 121; https://doi.org/10.3390/microorganisms12010121 - 7 Jan 2024
Cited by 2 | Viewed by 3196
Abstract
Dental caries is a significant oral and public health problem worldwide, especially in low-income populations. The risk of dental caries increases with frequent intake of dietary carbohydrates, including sugars, leading to increased acidity and disruption of the symbiotic diverse and complex microbial community [...] Read more.
Dental caries is a significant oral and public health problem worldwide, especially in low-income populations. The risk of dental caries increases with frequent intake of dietary carbohydrates, including sugars, leading to increased acidity and disruption of the symbiotic diverse and complex microbial community of health. Excess acid production leads to a dysbiotic shift in the bacterial biofilm composition, demineralization of tooth structure, and cavities. Highly acidic and acid-tolerant species associated with caries include Streptococcus mutans, Lactobacillus, Actinomyces, Bifidobacterium, and Scardovia species. The differences in microbiotas depend on tooth site, extent of carious lesions, and rate of disease progression. Metagenomics and metatranscriptomics not only reveal the structure and genetic potential of the caries-associated microbiome, but, more importantly, capture the genetic makeup of the metabolically active microbiome in lesion sites. Due to its multifactorial nature, caries has been difficult to prevent. The use of topical fluoride has had a significant impact on reducing caries in clinical settings, but the approach is costly; the results are less sustainable for high-caries-risk individuals, especially children. Developing treatment regimens that specifically target S. mutans and other acidogenic bacteria, such as using nanoparticles, show promise in altering the cariogenic microbiome, thereby combatting the disease. Full article
(This article belongs to the Special Issue Microbiology of Oral Diseases 2.0)
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