Special Issue "Advantages of Three Dimensional (3D) Cell Cultures"
A special issue of Microarrays (ISSN 2076-3905).
Deadline for manuscript submissions: closed (15 December 2014)
Dr. Mohammad Reza Lornejad-Schäfer
zet - BioMed-zet Life Science GmbH, Industriezeile 36/I, A-4020 Linz, Austria
Phone: +43 770325250
Fax: +43 770325213
Interests: three-dimensional (3D) cell culture; in vitro models; gene expression; microarray
In the last years progress has been made that the common technique where adherent cells grow in monolayers in two-dimensional (2D) cell culture has its limitations. When cultured in the long-term in 2D, the supply of nutrients is insufficient, the cell-cell and cell-material interactions are unphysiological and most of the cells will not stay viable. The upcoming three-dimensional (3D) cell culture models promise to overcome these disadvantages and should resemble more likely the in vivo situation of tissues or organs. Currently, many different 3D cell culture models using different cell types, conditions and materials are under investigation. All of them is common that they must improve their advantages for basic and applied research. Microarrays can be important tools to analyze the characteristic gene expression profiles of the 3D cell culture models, doing comparative studies, and to define the 3D culture effects. The special issue invites contributions to publish their results about gene expression profiling in different 3D cell culture models.
It will be of interest to the readers of this special issue to show, how 3D cell culture has influence on cell proliferation, cell differentiation, cell viability, general cell functionality, response to stimuli and in metabolism in comparison to highlight its advantages for basic and applied research.
Dr. Mohammad Reza Lornejad-Schafer
Dr. Christine Schäfer
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microarrays is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- gene expression
- three-dimensional (3D) cell culture
- two-dimensional (2D) cell culture
- in vitro model