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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Food Intake and Bioactive Metabolism in Humans

edited by Anallely López-Yerena and Emily P. Laveriano Santos

submission deadline 15 Jan 2026 | 3 articles | Viewed by 5544 | Submission Open

Keywords: bioactive compounds; phytochemical; carotenoids; polyphenols; oxylipins; gut microbiota; bioavailability; personalized nutrition; functional foods; disease prevention

(This special issue belongs to the Section Nutrition and Metabolism)

Cardiovascular Biomarkers and Metabolism in Cardiovascular Diseases

edited by Mark G. Filipovic, Corina Manuela Bello and Markus M. Luedi

submission deadline 15 Jan 2026 | 1 articles | Viewed by 2830 | Submission Open

Keywords: cardiovascular; biomarkers; risk factors; outcome; prognostication; metabolism; metabolomics; risk markers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

LC-MS/MS Analysis for Plant Secondary Metabolites, 2nd Edition

edited by Tiantian Ye

submission deadline 15 Jan 2026 | 2 articles | Viewed by 1553 | Submission Open

Keywords: liquid chromatography; mass spectrometry; secondary metabolites; metabolomics; abiotic and biotic stress; plant development

(This special issue belongs to the Section Plant Metabolism)

Intestinal Health and Metabolites in Farm Animals—2nd Edition

edited by

Qian Jiang

and Junquan Tian

submission deadline 19 Jan 2026 | Viewed by 143 | Submission Open

Keywords: metabolites; intestinal health; oxidative stress; inflammation; epithelial barrier

(This special issue belongs to the Section Animal Metabolism)

Machine Learning in Metabolomics: Unlocking the Future of Data Analysis

edited by

Boryana Petrova

and Arzu Tugce Guler

submission deadline 23 Jan 2026 | 3 articles | Viewed by 4667 | Submission Open

Keywords: metabolomics; MS imaging; machine learning; AI; multi-omics; integration; biomarker discovery; compound annotation; spectra interpretation

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolic Dysregulation in Fatty Liver Disease

edited by Ambrin Farizah Babu and

Youfei Guan

submission deadline 31 Jan 2026 | 3 articles | Viewed by 11094 | Submission Open

Keywords: metabolic dysregulation; metabolic homeostasis; insulin resistance; oxidative stress; lipid metabolism; glucose metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Interactions Between Exercise Physiology and Metabolism

edited by

Lijing Gong

and Enming Zhang

submission deadline 31 Jan 2026 | 6 articles | Viewed by 10143 | Submission Open

Keywords: exercise; metabolism; physical activity; chronic disease prevention; exerkines

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolism and Nutrition in Fish

edited by

Lei Wang

, Peng Tan and Rantao Zuo

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8785 | Submission Open

Keywords: fish; metabolism; nutrition; feed additives; lipid; protein; requirements

(This special issue belongs to the Section Animal Metabolism)

Comprehensive Insights into Metabolic Pathways: Genome-Scale Modeling Techniques

edited by

Priyanka Baloni

submission deadline 31 Jan 2026 | 4 articles | Viewed by 6800 | Submission Open

Keywords: metabolism; systems biology; genome-scale metabolic modeling; multi-omics data; data integration; data analysis; metabolic regulation; biomarker; drug targets

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomic Fingerprinting: Challenges and Opportunities

edited by Christina Virgiliou and

Olga-Angeliki Begou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5882 | Submission Open

Keywords: metabolomics/metabonomics; mass spectrometry; metabolome; HRMS; hyphenated techniques

(This special issue belongs to the Section Integrative Metabolomics)

Clinical Nutrition and Metabolic Diseases

edited by

Desirée Victoria-Montesinos

Ana María García-Muñoz

and

José Francisco López-Gil

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5643 | Submission Open

Keywords: clinical nutrition; metabolic disorders; nutritional intervention; metabolic health; disease prevention; biomarkers; nutritional therapy

(This special issue belongs to the Section Nutrition and Metabolism)

Psoriasis and Metabolic Syndrome

edited by Anna Baran

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5406 | Submission Open

Keywords: psoriasis; psoriatic arthritis; metabolic diseases; genetic and epigenetic factors; markers; therapy; immunology; pathogenesis; lipids

(This special issue belongs to the Section Lipid Metabolism)

Liver Injury and Regeneration—Metabolic Research

edited by Miguel Suárez Matías

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4774 | Submission Open

Keywords: metabolism-associated steatotic liver disease; metabolic syndrome; chronic liver disease; liver fibrosis; hepatocellular carcinoma; metabolomic; endoscopy; non-invasive liver disease assessment; artificial intelligence; machine learning

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Artificial Intelligence and Machine Learning in Metabolomics

edited by

Robert Winkler

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2712 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; metabolomics; integrative approaches

(This special issue belongs to the Section Integrative Metabolomics)

Advances in Phytomedicine Intervention on Metabolic Disorders

edited by

Hong Qin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2378 | Submission Open

Keywords: metabolic disorders; glucose and lipid metabolism; insulin resistance; non-communicable diseases; energy imbalance; nutrients; phytochemicals; plant ac-tive components; inflammation; signaling pathway

(This special issue belongs to the Section Nutrition and Metabolism)

Current Research in Metabolic Syndrome and Cardiometabolic Disorders

edited by

Ciprian Ilie Rosca

and

Yunping Qiu

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2256 | Submission Open

Keywords: metabolic syndrome; obesity; dyslipidemias; hyperuricemia; diabetes mellitus; cardiovascular diseases; heart failure; arrythmias; acute or chronic coronary syndromes; SGLT2-inhibitors; metabolic liver diseases; COVID-19 infection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Connections Between Nutrition, Epidemiology, and Metabolism

edited by

Kijoon Kim

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1493 | Submission Open

Keywords: nutritional epidemiology; metabolism; antioxidants; medicinal herbs; functional ingredients; chronic disease; public health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Impact of Polyphenols on Metabolic Health and Disease

edited by

Si Qin

and Kozue Sakao

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1428 | Submission Open

Keywords: polyphenols; metabolic diseases; molecular mechanisms; intervention; AI

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolism of Bioactives and Natural Products: 2nd Edition

edited by Kamila Misiakiewicz-Has, Barbara Wiszniewska and

Sylwia Rzeszotek

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1111 | Submission Open

Keywords: natural products; bioactive; medicinal plants; phytochemicals; isoflavones; triterpenes; coumarins; alkaloids; prebiotics; carotenoids; polyphenols; organosulfur compounds

(This special issue belongs to the Section Nutrition and Metabolism)

Plant Metabolome and Metabolomics

edited by

Subhash Minocha

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1005 | Submission Open

Keywords: metabolomics; LC/MS-based metabolomics; plant science; metabolic pathways; biotechnology applications; sustainable agriculture

Metabolic Syndrome and Non-Alcoholic Liver Disease—Second Edition

edited by

Mircea-Catalin Fortofoiu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 923 | Submission Open

Keywords: metabolic syndrome; non-alcoholic fatty liver disease (NAFLD); insulin resistance; obesity; type 2 diabetes; liver cirrhosis; dyslipidemia; NAFLD treatment; hepatic steatosis; cardiovascular risk

(This special issue belongs to the Section Lipid Metabolism)

Bioenergetics in Diet and Metabolism: Nutritional Pathways to Health

edited by

Cennet Yıldız

and

Xinhui Wang

submission deadline 31 Jan 2026 | Viewed by 333 | Submission Open

Keywords: bioenergetics; metabolic efficiency; energy metabolism; nutritional interventions; diet-induced thermogenesis; macronutrient composition; metabolic health; metabolic disorders; biothermodynamics; entropy

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Crosstalk in the Tumor Microenvironment

edited by

Drenka Trivanovic

Ristic Biljana

and

Vesna M. Ćorić

submission deadline 31 Jan 2026 | Viewed by 255 | Submission Open

Keywords: cancer; oncometabolites; tumor microenvironment; metabolic crosstalk

(This special issue belongs to the Section Cell Metabolism)

Bioactive Metabolites from Fungal Endophytes Associated with Medicinal Plants

edited by

Zhong-Hua Tang

and Chun-Hao Chang

submission deadline 31 Jan 2026 | Viewed by 227 | Submission Open

Keywords: medicinal plants; fungal endophytes; bioactive metabolites; symbiotic interaction; biosynthetic gene clusters; plant– microbe co-evolution; natural product discovery; metabolomics; synthetic biology; antimicrobial activity

(This special issue belongs to the Section Plant Metabolism)

Hypoxia and Its Role in Cellular Metabolism: Mechanisms and Implications

edited by

Raja Gopal Reddy Mooli

Hang Cheng

and

Nathan Lanning

submission deadline 31 Jan 2026 | Viewed by 215 | Submission Open

Keywords: oxygen; hypoxia; metabolism; Hypoxia Inducible Factors (HIFs); prolyl hydroxylase domain-containing enzymes (PHDs); metabolic regulation; glucose metabolism; fatty acid metabolism; TCA cycle; metabolites

(This special issue belongs to the Section Cell Metabolism)

Zebrafish Models in the Study of Diabetes and Metabolic Dysfunction

edited by Liqing Zang

submission deadline 31 Jan 2026 | Viewed by 185 | Submission Open

Keywords: zebrafish; diabetes; obesity; metabolic dysfunction; insulin resistance; hyperglycemia; lipid metabolism; drug screening; nutraceuticals; gene editing; high-fat diet; metabolomics

(This special issue belongs to the Section Animal Metabolism)

Metabolomic Strategies for Deep Systems Profiling Towards Biomarker Discovery and Precision Medicine

edited by

Silvia Valentinuzzi

and

Troy D. Wood

submission deadline 31 Jan 2026 | Viewed by 162 | Submission Open

Keywords: metabolomics; biomarker discovery; mass spectrometry; omics integration; molecular signatures; precision medicine

(This special issue belongs to the Section Integrative Metabolomics)

Metabolic Changes During Pre- and Post-Harvest Fruit and Vegetable Decay, Ripening and Senescence—2nd Edition

edited by

Analía Concellón

and

María José Zaro

submission deadline 2 Feb 2026 | 1 articles | Viewed by 1264 | Submission Open

Keywords: pre- and post-harvest technology; bio-stimulants and abiotic stress; nutritional quality; metabolic pathway; bioactive compounds; chilling injury

(This special issue belongs to the Section Plant Metabolism)

Nutritional Metabolism and Metabolome in Plants

edited by

Chuanying Fang

and Kang Li

submission deadline 10 Feb 2026 | Viewed by 306 | Submission Open

Keywords: nutritional metabolism; metabolomic; plant growth; development; and stress responses; metabolism-environmental factor interactions; genetic and molecular mechanisms; applications of plant metabolites

(This special issue belongs to the Section Plant Metabolism)

Vitamin D Metabolism and Human Health

edited by

Magdalena Kowalówka

Marta Karaźniewicz-Łada

and

Ilona Górna

submission deadline 12 Feb 2026 | 2 articles | Viewed by 10638 | Submission Open

Keywords: vitamin D; metabolites vitamin D; metabolic pathways; metabolic perturbations; vitamin D receptor; enzymes; polymorphism; vitamin D deficiency; health; metabolic diseases; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

NMR-Based Metabolomics in Biomedicine and Food Science

edited by

Gaia Meoni

and

Alessia Vignoli

submission deadline 13 Feb 2026 | 3 articles | Viewed by 3490 | Submission Open

Keywords: metabolomics; NMR; biomedicine; food; fingerprinting; profiling; AI; ML

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolism in Kidney Disease

edited by

Vincenzo Calabrese

Elisa Longhitano

and

Domenico Santoro

submission deadline 15 Feb 2026 | 2 articles | Viewed by 2492 | Submission Open

Keywords: biomarkers; CKD; dialysis; electrolytes; metabolism; inflammation; survey

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Nutrition and Exercise on Cardiometabolic Health

edited by

Sam Emerson

submission deadline 16 Feb 2026 | 2 articles | Viewed by 3186 | Submission Open

Keywords: cardiovascular health; metabolic health; diet; nutrition; exercise; physical activity; body composition; obesity; metabolites; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Role of Lipid Metabolism in Cardiovascular Health

edited by Irma Magaly Rivas Serna and

Timothy O'Toole

submission deadline 16 Feb 2026 | 1 articles | Viewed by 1442 | Submission Open

Keywords: metabolism of lipids; lipid classes; lipid species; cardiovascular health; lipidomics; cardiometabolic disease; cardiovascular disease; atherosclerosis; dyslipidemia; phospholipids; glyceride lipids; non-glyceride lipids; sphingolipids; ceramides; cardiac biomarkers; mechanism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomic Insights: Interplay Between Metabolism and Immune Response in Cancer

edited by

Dimitra Rafailia Bakaloudi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1321 | Submission Open

Keywords: metabolites; metabolism; cancer; immune response; immunotherapy; immunometabolism

(This special issue belongs to the Section Cell Metabolism)

Secondary Metabolites and Their Activities: From the Identification to the Biological Investigation

edited by Valeria Cavalloro and

Emanuela Martino

submission deadline 28 Feb 2026 | 5 articles | Viewed by 15370 | Submission Open

Keywords: active metabolites; green extraction; bioactivity; natural products; structural elucidation

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Emerging Applications of Metabolomics in Fermented Food

edited by

Eiichiro Fukusaki

, Akira Oikawa,

Yasuyo Sekiyama

and Kazuhiro Iwashita

submission deadline 28 Feb 2026 | 4 articles | Viewed by 10190 | Submission Open

Keywords: food metabolomics; fermented food; fermentation; fermentation microorganisms; flavor; food secondary function; sensory evaluation; health-promoting function; food ternary function; nutrition

(This special issue belongs to the Section Food Metabolomics)

Insights into the Metabolic Absorption of Bioactive Peptides Derived from Food Sources

edited by

Boqun Liu

submission deadline 28 Feb 2026 | 3 articles | Viewed by 8747 | Submission Open

Keywords: peptide; absorption; metabolism; structure– function relationships; metabolic pathways

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in Food Metabolomics for Functional Food Development and Analysis

edited by

Amanda J. Lloyd

and

MJ Pilar Martinez-Martin

submission deadline 28 Feb 2026 | 5 articles | Viewed by 7405 | Submission Open

Keywords: natural food fortification; functional foods; bioactive compounds; nutraceuticals; food biofortification; food analysis; nutritional enhancement; food testing; metabolomics

(This special issue belongs to the Section Food Metabolomics)

Novel Approaches for Metabolomics in Drugs and Biomarkers Discovery: 2nd Edition

edited by

Cecília R.C. Calado

submission deadline 28 Feb 2026 | 6 articles | Viewed by 6811 | Submission Open

Keywords: metabolomics; drugs discovery; biomarkers discovery; diagnostic; prognosis

(This special issue belongs to the Section Advances in Metabolomics)

Phytochemicals and Pharmacological Significance of Plant Secondary Metabolites in Medicine

edited by

Katarzyna Jakimiuk

and Arkadiusz Surażyński

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5834 | Submission Open

Keywords: natural plant products; biological and pharmacological activity; isolation; disease prevention and treatment; natural plant drug discovery

(This special issue belongs to the Section Plant Metabolism)

Advances in Metabolomics for Precision Medicine: From Biomarker Discovery to Clinical Applications

edited by Adam D. Kennedy and Greg Michelotti

submission deadline 28 Feb 2026 | 5 articles | Viewed by 5636 | Submission Open

Keywords: metabolomics; precision medicine; clinical disease; biomarkers; therapeutics; clinical metabolomics; nutrition; functional medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioactive Metabolites from Plants

edited by

Luis Francisco Salomé-Abarca

and

Dejan Godjevac

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5285 | Submission Open

Keywords: metabolites; bioactivity; identification; quantification; metabolomics; nutraceuticals; antibiosis; antixenosis; medicinal

(This special issue belongs to the Section Plant Metabolism)

Metabolomics Studies in Ruminant Models: Unraveling Nutritional Physiology and Health

edited by

Jože Starič

and

Marko R. Cincovic

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4704 | Submission Open

Keywords: feed supplements; metabolic profiles; metabolic biomarkers; metabolic stress; metabolomics

(This special issue belongs to the Section Advances in Metabolomics)

Lipid Biomarkers and Cardiometabolic Diseases—2nd Edition

edited by

Hyun Suk Yang

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4671 | Submission Open

Keywords: lipid profiles; lipid metabolism; cholesterol; dietary fat; cardiovascular diseases; metabolic diseases

(This special issue belongs to the Section Lipid Metabolism)

Advances in Murine Models for Metabolic Diseases: Insights into Diabetes, Obesity, and Cardiovascular Conditions

edited by

Samuel Treviño

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4269 | Submission Open

Keywords: murine models; metabolic diseases; molecular mechanisms; biochemical pathways; pharmacological strategies; interactome; comorbidities; metabolic phenotypes; novel techniques

(This special issue belongs to the Section Nutrition and Metabolism)

Effects of Stress on Animal Metabolism

edited by

Krystyna Pierzchala-Koziec

and Colin Scanes

submission deadline 28 Feb 2026 | 4 articles | Viewed by 3833 | Submission Open

Keywords: stressors; ACTH; glucocorticoids; mineralocorticoids; opioids; glycemia; growth; development; lactation; pregnancy

(This special issue belongs to the Section Animal Metabolism)

New Trends in Drug Pharmacokinetics and Metabolism Research

edited by

Rongjin Sun

and Steven C. Laizure

submission deadline 28 Feb 2026 | Viewed by 3217 | Submission Open

Keywords: local bioavailable drug; drug– herb interactions; machine learning; advanced modeling techniques; gut microbiome; in vitro to in vivo extrapolation; monoclonal antibodies; peptides; oligonucleotides

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Bioactive Plant Extracts: Phytochemical Characterization, Isolation and Biological Evaluation

edited by

Sergio Ortiz

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2102 | Submission Open

Keywords: extraction; metabolomics; phytochemical dereplication; isolation of plant metabolites; biological evaluation

(This special issue belongs to the Section Plant Metabolism)

Synthetic Biology Approaches for Expanding the Metabolic Capabilities of E. coli

edited by

Angelo Bañares

and Kei Anne Baritugo

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1701 | Submission Open

Keywords: synthetic biology; Escherichia coli (E. coli); metabolic engineering; genome editing (crispr-cas9); novel metabolic pathways; high-value chemicals; biofuels; bioremediation; environmental sensing; microbial cell factory

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

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