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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolite Profiles in Inflammatory Diseases

edited by Rodica Pădureanu and

Ionut Donoiu

submission deadline 15 Dec 2025 | 3 articles | Viewed by 2741 | Submission Open

Keywords: gut; inflammation; markers; metabolomics; multiple sclerosis; rheumatoid arthritis; lung disease; osteoarthritis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Expanding Boundaries in Spatial Metabolomics and Lipidomics: Advances in Mass Spectrometry Imaging

edited by

Vanna Denti

and

Simone Serrao

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1319 | Submission Open

Keywords: spatial omics; mass spectrometry imaging; multimodal; imaging data analysis; spatial functional analysis; small-molecule biochemistry

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics in Plant Natural Products Research, 2nd Edition

edited by

Junsong Wang

submission deadline 30 Dec 2025 | 3 articles | Viewed by 1948 | Submission Open

Keywords: natural products; metabolomics; plant– environment interactions; chemical markers; active principles; LC/MS; GC/MS; NMR

(This special issue belongs to the Section Plant Metabolism)

Exploring Uric Acid and Beyond

edited by

Pietro Cirillo

and

Claudio Borghi

submission deadline 31 Dec 2025 | 8 articles | Viewed by 25049 | Submission Open

Keywords: uric acid; cardiovascular risk; kidney disease; obesity; diabetes; lipid metabolism; immune programming

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Brain Metabolic Alterations in Neurodegenerative Diseases

edited by Luciene Bruno Vieira and Fabíola Mara Ribeiro

submission deadline 31 Dec 2025 | 3 articles | Viewed by 15825 | Submission Open

Keywords: glucose metabolism; mitochondrial dysfunction; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Insights into Natural Health Products and Dietary Supplements for Human Health

edited by

Julia Solnier

and Mary Hardy

submission deadline 31 Dec 2025 | 2 articles | Viewed by 13330 | Submission Open

Keywords: bioactive natural compounds; traditional medicine; metabolic pathways; absorption; distribution; metabolism; and excretion (ADME); clinical efficacy; pharmacokinetics; nutritional supplements; health benefits; safety and toxicology; delivery systems

(This special issue belongs to the Section Nutrition and Metabolism)

Lipid Metabolism Disorders in Obesity

edited by

Klaudia Sztolsztener

and

Elzbieta Supruniuk

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5468 | Submission Open

Keywords: fatty liver diseases; overweight and obesity; cardiometabolic risks; lipid metabolism; metabolic syndrome; adipose tissue

(This special issue belongs to the Section Lipid Metabolism)

Harnessing the Power of NMR Metabolomics in Unraveling Metabolic Diseases

edited by

Chi-Jen Lo

and

Mei-Ling Cheng

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4661 | Submission Open

Keywords: metabolomics; NMR; precision medicine; translational medicine; metabolic disease

(This special issue belongs to the Section Integrative Metabolomics)

Interactions of Diet, Exercise, and Metabolism

edited by

Raphael Gonçalves de Oliveira

, Dartagnan Pinto Guedes and Laís Campos de Oliveira

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4608 | Submission Open

Keywords: physical exercise; physical fitness; physical activity; diet; food; and nutrition; feeding behavior; me-tabolism; metabolic process

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipid Signaling, Therapeutics and Controlled-Release

edited by Wen-Lung Ma and Hung-Yu Sun

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4349 | Submission Open

Keywords: lipid signaling; therapeutics; controlled release

(This special issue belongs to the Section Lipid Metabolism)

Primary Hyperparathyroidism: Mechanisms and Treatment

edited by Elena Castellano and

Federica Saponaro

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4056 | Submission Open

Keywords: primary pyperparathyroidism; mechanism; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Energy Metabolism in Brown Adipose Tissue

edited by

Chuanhai Zhang

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3801 | Submission Open

Keywords: energy metabolism; thermogenic fat tissue; metabolites; mitochondrial function; ER stress

(This special issue belongs to the Section Cell Metabolism)

Insights into Tumor Cell Metabolism and Epigenetics

edited by

Sara Granja

, Vera Miranda-Gonçalves and Filipa Vieira

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3368 | Submission Open

Keywords: Warburg effect; epigenetic alterations; metabolic reprogramming; epigenome; transcriptional regula-tion; fatty acid metabolism

(This special issue belongs to the Section Cell Metabolism)

Advancing Metabolic/Microbial Biomarker Applications in Disease Prevention, Diagnosis and Public Health

edited by

Pengcheng Tu

and

Bei Gao

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3217 | Submission Open

Keywords: biomarkers; disease processes; gut microbiome; multi-omics; metabolic indicators; clinical applications

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Neurodegenerative Diseases, 2nd Edition

edited by

Stewart Francis Graham

and Nazia M. Saiyed

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2680 | Submission Open

Keywords: neurodegenerative disease; Alzheimer’ s; Parkinson’ s; Huntington’ s; ALS; neurodegeneration; bi-omarkers; metabolism; etiology; pathophysiology; biochemistry

(This special issue belongs to the Section Cell Metabolism)

Mitochondrial Metabolism in Health and Disease: A Clinical Perspective

edited by

Joao Pessoa

Ana Duarte

and

Susana P. Pereira

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2533 | Submission Open

Keywords: mitochondrion; bioenergetics; oxidative stress; calcium homeostasis; apoptosis; cancer; metabolic diseases; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Cell Metabolism)

Advancing Metabolite Biomarkers in Neurodegenerative Disease: Discovery, Integration, and Therapeutic Potential

edited by Robert Logan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1907 | Submission Open

Keywords: biomarkers; neurodegeneration; metabolites; metabolic pathways; metabolomic; Alzheimer’ s disease; Parkinson’ s disease

(This special issue belongs to the Section Cell Metabolism)

Advances in Plant and Microbial Metabolic Engineering

edited by

Filippos Ververidis

and

Emmanouil Trantas

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1587 | Submission Open

Keywords: plant metabolic engineering; primary and secondary metabolism; plant synthetic biology; natural products; molecular farming; molecular breeding; food security

(This special issue belongs to the Section Plant Metabolism)

Metabolic and Endocrine Adaptations in Aquatic Animals

edited by

Anapaula Sommer Vinagre

, Luiz C. Kucharski and Mariana Leivas Müller Hoff

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1586 | Submission Open

Keywords: aquatic animal metabolism; animal endocrinology; fish metabolism; fish endocrinology; crustacean metabolism; crustacean endocrinology

(This special issue belongs to the Section Animal Metabolism)

Exploring Innovations in Secondary Metabolites and Their Effects on Pain, Inflammation and Metabolic Syndrome

edited by

Raquel Cariño-Cortés

and

Mario Ortiz

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1292 | Submission Open

Keywords: secondary metabolites; pain; inflammation; chronic-degenerative diseases; chemoprevention; metabolic syndrome; plants

(This special issue belongs to the Section Plant Metabolism)

Metabolic and Lipidomic Reprogramming in Cancer: Mechanisms and Therapeutic Potential

edited by

Sara Vicente-Muñoz

and

Mariaelena Pistoni

submission deadline 31 Dec 2025 | 1 articles | Viewed by 826 | Submission Open

Keywords: cancer hallmarks; metabolomics; lipidomics; stable isotopes; biomarkers; therapeutic targets; metabolic pathways

(This special issue belongs to the Section Cell Metabolism)

Metabolic Regulation of Reproductive Physiology in Livestock Species

edited by

Gabriele Brecchia

Giulio Curone

and Stella Agradi

submission deadline 31 Dec 2025 | Viewed by 563 | Submission Open

Keywords: metabolic regulation; reproductive physiology; livestock reproduction; energy balance; nutrient me-tabolism; fertility biomarkers; hormonal regulation; metabolic disorders; reproductive efficiency

(This special issue belongs to the Section Animal Metabolism)

Metabolic Reprogramming in Cancer: New Frontiers for Therapeutic Intervention

edited by Songhua Hu, Yahui Wang and

Daniel Oscar Cicero

submission deadline 31 Dec 2025 | Viewed by 492 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; metabolic plasticity; cancer heterogeneity; therapeutic resistance; tumor microenvironment; combination therapies

(This special issue belongs to the Section Cell Metabolism)

Myostatin: A Key Regulator of Skeletal Muscle Metabolism and Development

edited by

Emiliano Lasagna

and

Ishaku L. Haruna

submission deadline 31 Dec 2025 | Viewed by 473 | Submission Open

Keywords: myostatin; MSTN; GDF8; muscle development; muscular hypertrophy; metabolites and metabolism; omics sciences; myostatin pathways

(This special issue belongs to the Section Animal Metabolism)

Metabolomics and MASLD: Pathways, Biomarkers, and Clinical Insights

edited by

Amedeo Lonardo

and

Ralf Weiskirchen

submission deadline 31 Dec 2025 | Viewed by 441 | Submission Open

Keywords: amino acids; bile acids; cardiovascular disease; cholesterol; ceramides; cirrhosis; diabetes; eicosanoids; HIV; hyper-tension; insulin resistance; lipidome; lipidomics; lipotoxicity; liver fibrosis; MASLD/MASH; metabolome; metabolomics; microbiome; NAFLD/NASH omics; obesity; precision medicine; phospholipids; sphingolipids; triglycerides; SCFA; tar-geted metabolomics; TMAO; uric acid; HCC; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolites in Animal Nutrition and Physiological Regulations Under Stress Conditions

edited by

Hieu Huu Le

and

Majid Shakeri

submission deadline 31 Dec 2025 | Viewed by 398 | Submission Open

Keywords: metabolic; nutrition; amino acids; meat quality; metabolites; fatty acids; non-esterified fatty acids (NEFA); physiology; metabolism; dietary supplementation

(This special issue belongs to the Section Animal Metabolism)

Women’s Special Issue Series: Metabolomic Profiling Technology

edited by

Thusitha W. Rupasinghe

and

RuAngelie Edrada-Ebel

submission deadline 31 Dec 2025 | Viewed by 323 | Submission Open

Keywords: metabolomics; metabolomic profiling technology; metabolism; analytical chemistry; NMR; mass spectrometry

(This special issue belongs to the Section Metabolomic Profiling Technology)

Obesity and Metabolic Syndrome in Children: Insights, Interventions and Emerging Perspectives, 2nd Edition

edited by

Teofana Otilia Bizerea-Moga

and Rade Vukovic

submission deadline 31 Dec 2025 | Viewed by 232 | Submission Open

Keywords: metabolic syndrome in children; childhood obesity; hypertension; glucose tolerance; insulin resistance; nutritional status; metabolomics; oxidative stress; trace elements— selenium

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Phytochemicals on Human Metabolism

edited by

Henrique Cerqueira

and

Eric Gumpricht

submission deadline 31 Dec 2025 | Viewed by 164 | Submission Open

Keywords: phytochemistry; bioactive compounds; metabolism; nutritional interventions; energy balance; oxidative stress; inflammation

(This special issue belongs to the Section Nutrition and Metabolism)

Application of Urinary Metabolomics in Early Disease Detection

edited by

Casey Burton

submission deadline 31 Dec 2025 | Viewed by 145 | Submission Open

Keywords: urinary metabolomics; biomarkers; early disease detection; analytical method development; therapeutic response monitoring

(This special issue belongs to the Section Advances in Metabolomics)

MicroRNAs in Lipid Metabolism

edited by Pablo Fernández-Tussy

submission deadline 31 Dec 2025 | Viewed by 141 | Submission Open

Keywords: microRNAs; lipid metabolism; lipoproteins; obesity; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Role of Cell Metabolism in Infective Diseases

edited by

Chongshan Dai

submission deadline 31 Dec 2025 | Viewed by 103 | Submission Open

Keywords: metabolites; immunology; drug therapy; new compounds; cellular metabolism; infectious diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Chemical Exposure on Endocrine and Reproductive Functions, 2nd Edition

edited by Renata Marino Romano and Caroline Serrano-Nascimento

submission deadline 31 Dec 2025 | Viewed by 82 | Submission Open

Keywords: endocrine-disrupting chemicals exposure impact on metabolic diseases; reproductive failure; infertility; endocrine disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Food Intake and Bioactive Metabolism in Humans

edited by Anallely López-Yerena and Emily P. Laveriano Santos

submission deadline 15 Jan 2026 | 3 articles | Viewed by 4736 | Submission Open

Keywords: bioactive compounds; phytochemical; carotenoids; polyphenols; oxylipins; gut microbiota; bioavailability; personalized nutrition; functional foods; disease prevention

(This special issue belongs to the Section Nutrition and Metabolism)

Cardiovascular Biomarkers and Metabolism in Cardiovascular Diseases

edited by Mark G. Filipovic, Corina Manuela Bello and Markus M. Luedi

submission deadline 15 Jan 2026 | 1 articles | Viewed by 2383 | Submission Open

Keywords: cardiovascular; biomarkers; risk factors; outcome; prognostication; metabolism; metabolomics; risk markers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

LC-MS/MS Analysis for Plant Secondary Metabolites, 2nd Edition

edited by Tiantian Ye

submission deadline 15 Jan 2026 | 1 articles | Viewed by 1112 | Submission Open

Keywords: liquid chromatography; mass spectrometry; secondary metabolites; metabolomics; abiotic and biotic stress; plant development

(This special issue belongs to the Section Plant Metabolism)

Intestinal Health and Metabolites in Farm Animals—2nd Edition

edited by

Qian Jiang

and Junquan Tian

submission deadline 19 Jan 2026 | Viewed by 104 | Submission Open

Keywords: metabolites; intestinal health; oxidative stress; inflammation; epithelial barrier

(This special issue belongs to the Section Animal Metabolism)

Machine Learning in Metabolomics: Unlocking the Future of Data Analysis

edited by

Boryana Petrova

and Arzu Tugce Guler

submission deadline 23 Jan 2026 | 2 articles | Viewed by 3867 | Submission Open

Keywords: metabolomics; MS imaging; machine learning; AI; multi-omics; integration; biomarker discovery; compound annotation; spectra interpretation

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolic Dysregulation in Fatty Liver Disease

edited by Ambrin Farizah Babu and

Youfei Guan

submission deadline 31 Jan 2026 | 3 articles | Viewed by 9565 | Submission Open

Keywords: metabolic dysregulation; metabolic homeostasis; insulin resistance; oxidative stress; lipid metabolism; glucose metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Interactions Between Exercise Physiology and Metabolism

edited by

Lijing Gong

and Enming Zhang

submission deadline 31 Jan 2026 | 6 articles | Viewed by 9531 | Submission Open

Keywords: exercise; metabolism; physical activity; chronic disease prevention; exerkines

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolism and Nutrition in Fish

edited by

Lei Wang

, Peng Tan and Rantao Zuo

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8322 | Submission Open

Keywords: fish; metabolism; nutrition; feed additives; lipid; protein; requirements

(This special issue belongs to the Section Animal Metabolism)

Comprehensive Insights into Metabolic Pathways: Genome-Scale Modeling Techniques

edited by

Priyanka Baloni

submission deadline 31 Jan 2026 | 4 articles | Viewed by 5978 | Submission Open

Keywords: metabolism; systems biology; genome-scale metabolic modeling; multi-omics data; data integration; data analysis; metabolic regulation; biomarker; drug targets

(This special issue belongs to the Section Advances in Metabolomics)

Clinical Nutrition and Metabolic Diseases

edited by

Desirée Victoria-Montesinos

Ana María García-Muñoz

and

José Francisco López-Gil

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5264 | Submission Open

Keywords: clinical nutrition; metabolic disorders; nutritional intervention; metabolic health; disease prevention; biomarkers; nutritional therapy

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomic Fingerprinting: Challenges and Opportunities

edited by Christina Virgiliou and

Olga-Angeliki Begou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5230 | Submission Open

Keywords: metabolomics/metabonomics; mass spectrometry; metabolome; HRMS; hyphenated techniques

(This special issue belongs to the Section Integrative Metabolomics)

Psoriasis and Metabolic Syndrome

edited by Anna Baran

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4864 | Submission Open

Keywords: psoriasis; psoriatic arthritis; metabolic diseases; genetic and epigenetic factors; markers; therapy; immunology; pathogenesis; lipids

(This special issue belongs to the Section Lipid Metabolism)

Liver Injury and Regeneration—Metabolic Research

edited by Miguel Suárez Matías

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3974 | Submission Open

Keywords: metabolism-associated steatotic liver disease; metabolic syndrome; chronic liver disease; liver fibrosis; hepatocellular carcinoma; metabolomic; endoscopy; non-invasive liver disease assessment; artificial intelligence; machine learning

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Phytomedicine Intervention on Metabolic Disorders

edited by

Hong Qin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2273 | Submission Open

Keywords: metabolic disorders; glucose and lipid metabolism; insulin resistance; non-communicable diseases; energy imbalance; nutrients; phytochemicals; plant ac-tive components; inflammation; signaling pathway

(This special issue belongs to the Section Nutrition and Metabolism)

Artificial Intelligence and Machine Learning in Metabolomics

edited by

Robert Winkler

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2094 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; metabolomics; integrative approaches

(This special issue belongs to the Section Integrative Metabolomics)

Current Research in Metabolic Syndrome and Cardiometabolic Disorders

edited by

Ciprian Ilie Rosca

and

Yunping Qiu

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1837 | Submission Open

Keywords: metabolic syndrome; obesity; dyslipidemias; hyperuricemia; diabetes mellitus; cardiovascular diseases; heart failure; arrythmias; acute or chronic coronary syndromes; SGLT2-inhibitors; metabolic liver diseases; COVID-19 infection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Impact of Polyphenols on Metabolic Health and Disease

edited by