Special Issues

Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nutrition and Metabolism in Human Diseases 2nd Edition
edited by
submission deadline 31 Oct 2025 | 5 articles | Viewed by 8725
Keywords: nutrition; metabolism; nutrient; metabolite; disease
(This special issue belongs to the Section Nutrition and Metabolism)
Research of Inborn Errors of Metabolism submission deadline 31 Oct 2025 | 3 articles | Viewed by 3604
Keywords: inborn errors of metabolism; pathogenic mechanisms; bio-chemical pathway; inherited diseases; diagnosis
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Advances in LC-MS-Based Metabolomics: From (Un)targeted Screening to Structural Elucidation
edited by Andrea Castellaneta and
submission deadline 31 Oct 2025 | 3 articles | Viewed by 3511
Keywords: liquid chromatography; high-resolution and multi-stage mass spectrometry; lipidomics; structure elucidation; LC-MS methods for metabolite screening; quantitative method development
(This special issue belongs to the Section Metabolomic Profiling Technology)
Research on Lipid Metabolism in Animals
edited by , and Zhenlong Wang
submission deadline 31 Oct 2025 | 2 articles | Viewed by 3157
Keywords: lipid metabolism; bile acid; gut microbiota; obesity; meat quality
(This special issue belongs to the Section Animal Metabolism)
Identification of Plant Metabolites: Characterization and Biological Activities, 2nd Edition submission deadline 31 Oct 2025 | 2 articles | Viewed by 2958
Keywords: natural compounds; plant metabolites; separation techniques; biological activities
(This special issue belongs to the Section Plant Metabolism)
Biosynthesis, Metabolism, and Physiological Functions of Gamma-Aminobutyric Acid (2nd Edition)
edited by and
submission deadline 31 Oct 2025 | 1 articles | Viewed by 2637
Keywords: gamma-aminobutyric acid; metabolism and metabolomics; biotechnology and bioengineering; biosynthesis; physiological function; gamma-aminobutyric-acid-producing microbes; methodology
(This special issue belongs to the Section Microbiology and Ecological Metabolomics)
Advances in Mass Spectrometry for Plant Metabolite Analysis: Techniques and Applications submission deadline 31 Oct 2025 | 1 articles | Viewed by 1755
Keywords: mass spectrometry; plant metabolomics; biomarker discovery; metabolic networks: metabolic flux; MS data analysis; metabolic diseases
(This special issue belongs to the Section Plant Metabolism)
Metabolomics of Human Nutrition: The Dot of Human Nutrition and the Circle of Soil, Plants, Animals and Microbes in Relation to It, 2nd Edition
edited by
submission deadline 31 Oct 2025 | 3 articles | Viewed by 1709
Keywords: human nutrition; metabolomics; physiology; biochemistry; dietetics; pathophysiology; soil science; crop science; animal husbandry; microbes
(This special issue belongs to the Section Nutrition and Metabolism)
Flavonoids: Novel Therapeutic Potential for Chronic Diseases
edited by Aleksandra Kozłowska and Shawn R. Campagna
submission deadline 31 Oct 2025 | 2 articles | Viewed by 1499
Keywords: flavonoids; chronic diseases; inflammation; diabetes; anthocyanins; cardiovascular diseases; neurodegenerative disorders; quercetin
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Role of Nutraceuticals in Metabolic Disorders: Mechanisms and Benefits
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1377
Keywords: nutraceuticals; functional foods; metabolic syndrome
(This special issue belongs to the Section Nutrition and Metabolism)
Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer Surgery: 2nd Edition
edited by , and Maximos Frountzas
submission deadline 31 Oct 2025 | 1 articles | Viewed by 533
Keywords: biomarkers; nutrition; metabolism; metabolomics; degenerative disease; Parkinson’ s disease; Alzheimer’ s disease; cardiovascular disease; gastrointestinal cancer surgery
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Evaluation of Metabolic Changes in Mice Under Chronic Toxic Substances Exposure
edited by and
submission deadline 31 Oct 2025 | Viewed by 295
Keywords: metabolomics; environmental contaminant; persistent organic pollutant; mass spectrometry; proteomics; toxicant; toxicological assessment; chronic toxicity; xenobiotic metabolism; lipidomic; dose– response relationship; molecular toxicology
(This special issue belongs to the Section Environmental Metabolomics)
Nutrition and Metabolism in Poultry submission deadline 10 Nov 2025 | 1 articles | Viewed by 1501 | Submission Open
Keywords: ingredient; feed additive; feed quality; nutrient utilization; intestinal health
(This special issue belongs to the Section Animal Metabolism)
Mechanistic Insights into Metabolic Interactions with the Tumor Microenvironment
edited by
submission deadline 15 Nov 2025 | 1 articles | Viewed by 1852 | Submission Open
Keywords: metabolism; tumor microenvironment; therapy; immune cells; clinical oncology; metabolic pathways
(This special issue belongs to the Section Cell Metabolism)
The Relationship Between Adipose Tissue Insulin Resistance and Metabolic Syndrome
edited by
submission deadline 15 Nov 2025 | Viewed by 143 | Submission Open
Keywords: adipose insulin resistance; metabolic syndrome; visceral adiposity; adipocytokines; insulin signaling; lipolysis dysregulation; cardiometabolic risk; lipotoxicity; adipose inflammation; insulin sensitivity
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Targeted and Non-Targeted LC- and GC-HRMS Workflows for the Analysis of Emerging Contaminants and the Environmental Exposome
edited by Lapo Renai and
submission deadline 16 Nov 2025 | 1 articles | Viewed by 1160 | Submission Open
Keywords: chromatography; high-resolution mass spectrometry; non-targeted analysis; exposome; data analysis; environmental analysis; pharmaceuticals; poly- and perfluorinated substances; personal care products; transformation products feature detection and identification
(This special issue belongs to the Section Environmental Metabolomics)
Diet, Gut Microbiota and Metabolic Health
edited by and
submission deadline 17 Nov 2025 | 2 articles | Viewed by 1685 | Submission Open
Keywords: diet; nutrition; gut microbiota; metabolites; metabolism
(This special issue belongs to the Section Animal Metabolism)
Neurometabolics in a Nutshell
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 666 | Submission Open
Keywords: neurometabolic disorders; rare diseases; diagnosis; differential diagnosis; treatment options
(This special issue belongs to the Section Cell Metabolism)
Effects of Various Exercise Methods on Metabolic Health
edited by and Won-Sang Jung
submission deadline 28 Nov 2025 | 3 articles | Viewed by 5533 | Submission Open
Keywords: exercise physiology; metabolism; insulin sensitivity; energy expenditure; cardiovascular health; resistance training; high-intensity interval training; hypoxia; mitochondrial function; metabolic syndrome
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Sex Differences in Physical Exercise and Dietary Habits Effects on Metabolic Health
edited by Hannah Cabre and
submission deadline 28 Nov 2025 | 3 articles | Viewed by 3819 | Submission Open
Keywords: sex differences; metabolomics; metabolites; menstrual cycle; aging; exercise performance; nutrition intervention; cardiometabolic
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Metabolic Biomarkers in Type 2 Diabetes: From Discovery to Application
edited by Eiji Kutoh and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 6836 | Submission Open
Keywords: metabolic biomarkers; type 2 diabetes (T2DM); glucose metabolism; insulin resistance; lipid profiles; diagnosis and prognosis
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Exploring and Expanding Horizons in Secondary Metabolites: Biosynthesis, Identification, Regulation and Biological Activity
edited by , and Claúdia Quintino Da Rocha
submission deadline 30 Nov 2025 | 3 articles | Viewed by 5826 | Submission Open
Keywords: secondary metabolites; biosynthesis; regulation; identification; plants; microorganisms; marine organisms; animals; bioactivity; drug discovery; natural products
(This special issue belongs to the Section Pharmacology and Drug Metabolism)
Environmental Metabolites Insights into Health and Disease
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 5685 | Submission Open
Keywords: environmental metabolites; probiotics; health; disease; toxic metabolites; protective metabolites; metabolomics; environmental exposure; molecular mechanisms; metabolic pathways
(This special issue belongs to the Section Environmental Metabolomics)
Mass Spectrometry-Based Metabolomics in Health and Disease: Targeted Analysis and Its Trends submission deadline 30 Nov 2025 | 3 articles | Viewed by 3600 | Submission Open
Keywords: mass spectrometry-based metabolomics; targeted metabolomics; health and disease; precision medi-cine; biomarker discovery; metabolic pathways
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
One-Carbon Metabolism in Pregnant Women, Fetuses, and Infants
edited by and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2581 | Submission Open
Keywords: folate cycle (5-methyltetrahydrofolate; folic acid; vitamin B12; serine; glycine); methionine cycle (homocysteine; methionine; S-adenosylmethionine; S-adenosylhomocysteine); choline metabolic pathway (betaine; choline); trans-sulfuration pathway (cysteine; taurine; vitamin B6); epigenetics; developmental origins of health and disease (DOHaD)
(This special issue belongs to the Section Nutrition and Metabolism)
Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease submission deadline 30 Nov 2025 | 2 articles | Viewed by 2102 | Submission Open
Keywords: oxidative stress; metabolism; cellular signaling; lipid metabolism; ROS
(This special issue belongs to the Section Lipid Metabolism)
Environmental Exposure and Its Effects on Cardio-Respiratory and Metabolic Health
edited by and Tatt Jhong Haw
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1065 | Submission Open
Keywords: environmental factors; pollution; cardiovascular; cardiometabolic risk factor; biomarkers; mechanisms; cardio-oncology; cardio-respiratory
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Metabolomics in Personalized Medicine submission deadline 30 Nov 2025 | 1 articles | Viewed by 930 | Submission Open
Keywords: metabolomics; personalized medicine; biomarkers; precision health; disease stratification; metabolic profiling; NMR spectroscopy; mass spectrometry; therapeutic response; systems biology
(This special issue belongs to the Section Advances in Metabolomics)
Phenological Regulation of Secondary Metabolism
edited by , Alma Rosa González-Esquinca and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 889 | Submission Open
Keywords: phenological fluctuations; metabolites’ phenological fluctuations; secondary metabolites; natural products; specialized metabolites
(This special issue belongs to the Section Plant Metabolism)
Proteomics and Metabolomics in Human Health and Disease submission deadline 30 Nov 2025 | 1 articles | Viewed by 787 | Submission Open
Keywords: proteomics; metabolomics; lipidomics; multi-omics; disease mechanisms; machine learning; omics integrations; artificial intelligence
(This special issue belongs to the Section Advances in Metabolomics)
The Role of Isotope Tracers in Investigating Metabolic Disorders
edited by Nadezda Khodorova
submission deadline 30 Nov 2025 | Viewed by 359 | Submission Open
Keywords: kinetics effect; isotope ratio mass spectrometry; biomarker; fluxomics; metabolomics; stable isotope; tracing experiments; mass spectrometry; breath tests
(This special issue belongs to the Section Metabolomic Profiling Technology)
The Future Perspective on Screening and Diagnosis of Inborn Errors of Metabolism
edited by Luiz Carlos Santana-Da-Silva, Olga Yaneth Echeverri-Peña and
submission deadline 30 Nov 2025 | Viewed by 243 | Submission Open
Keywords: inborn errors of metabolism (IEM); genetic disorders; diagnostics; biomarkers; omics sciences; imaging techniques (MRS; PET); molecular techniques (NGS; gene editing); personalized medi-cine; early detection
Imaging and Spectroscopic Based Methods to Understand Cancer Metabolism and Biology 2025
edited by
submission deadline 30 Nov 2025 | Viewed by 231 | Submission Open
Keywords: PET; CT; MRI; NMR; molecular imaging; optical imaging; opto-acoustic imaging; Raman imag-ing and spectroscopy; mass spectroscopy imaging; metabolic pathways; theranostic imaging; machine learning; deep learning; artificial intelligence; image analysis; tumors; cancer; cancer metabolism; cancer biology; tumor microenvironment; tumor heterogeneity
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Investigating the Impact of Teas on Metabolic Disorders: Insights into Underlying Mechanisms and Therapeutic Potential
edited by and
submission deadline 30 Nov 2025 | Viewed by 217 | Submission Open
Keywords: teas; metabolic disorders; mechanism of action; therapeutic potential; diabetes; obesity; cardiovascular diseases; biochemical properties; clinical studies; therapeutic strategies
(This special issue belongs to the Section Nutrition and Metabolism)
Exposome and Metabolic Effects: Neurological Implications of Environmental Pollutants
edited by and Fabio Castellana
submission deadline 30 Nov 2025 | Viewed by 176 | Submission Open
Keywords: exposome; environmental pollutants; metabolic effects; neurological implications; neurodegenerative diseases; cognitive dysfunction; brain metabolism; toxins; environmental health; developmental disorders; neurobiology; genetic predisposition; preventive strategies
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Autophagy and Antioxidant Pathways in Neurodegenerative Diseases submission deadline 30 Nov 2025 | Viewed by 152 | Submission Open
Keywords: neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; amyotrophic lateral sclerosis; autophagy; neuroinflammation; oxidative stress; antioxidant pathways; neuroprotection
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Metabolomics in Breath Biomarker Discovery
edited by Waqar Ahmed
submission deadline 30 Nov 2025 | Viewed by 139 | Submission Open
Keywords: exhaled breath volatiles; metabolomics; biomarkers; volatile organic compounds
(This special issue belongs to the Section Advances in Metabolomics)
Metabolomics in Disease Mechanisms and Drug Targets, 2nd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 126 | Submission Open
Keywords: metabolomics; disease mechanism; drug target; biomarker; disease prediction
(This special issue belongs to the Section Metabolomic Profiling Technology)
Advances in Gut Microbiome Metabolomics submission deadline 1 Dec 2025 | 2 articles | Viewed by 2999 | Submission Open
Keywords: gut microbiome– host interaction; cross talk; metabolomics; omics- technologies; microbiome signatures; new diagnostic tools; novel therapeutic strategies
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Metabolomics in Respiratory, Cardiovascular and Metabolic Disorders
edited by Joaquim Gea
submission deadline 1 Dec 2025 | Viewed by 154 | Submission Open
Keywords: metabolomics; small molecules; mass spectrometry; NMR; personalized medicine; biomarkers; car-diovascular disorders; respiratory diseases; endocrine metabolic abnormalities
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Metabolomics and Plant Defence, 2nd Edition
edited by and
submission deadline 5 Dec 2025 | 2 articles | Viewed by 1541 | Submission Open
Keywords: metabolomics; plant defence; biotic and abiotic stress; phytohormone; metabolites and metabolic homeostasis; metabolomic profiling methodology
(This special issue belongs to the Section Plant Metabolism)
Metabolite Profiles in Inflammatory Diseases
edited by Rodica Pădureanu and
submission deadline 15 Dec 2025 | 3 articles | Viewed by 2186 | Submission Open
Keywords: gut; inflammation; markers; metabolomics; multiple sclerosis; rheumatoid arthritis; lung disease; osteoarthritis
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Expanding Boundaries in Spatial Metabolomics and Lipidomics: Advances in Mass Spectrometry Imaging
edited by and
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1076 | Submission Open
Keywords: spatial omics; mass spectrometry imaging; multimodal; imaging data analysis; spatial functional analysis; small-molecule biochemistry
(This special issue belongs to the Section Advances in Metabolomics)
Metabolomics in Plant Natural Products Research, 2nd Edition
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 1082 | Submission Open
Keywords: natural products; metabolomics; plant– environment interactions; chemical markers; active principles; LC/MS; GC/MS; NMR
(This special issue belongs to the Section Plant Metabolism)
Exploring Uric Acid and Beyond submission deadline 31 Dec 2025 | 8 articles | Viewed by 22101 | Submission Open
Keywords: uric acid; cardiovascular risk; kidney disease; obesity; diabetes; lipid metabolism; immune programming
(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)
Meeting the Challenge of Metabolomics Analysis by Using Multidimensional Gas Chromatography with Mass Spectrometry submission deadline 31 Dec 2025 | 6 articles | Viewed by 18073 | Submission Open
Keywords: GC× GC; MDGC; metabolites; high-resolution mass spectrometry; metabolite profiling; metabolite fingerprinting; biomarker; plant secondary compounds; disease diagnosis
(This special issue belongs to the Section Metabolomic Profiling Technology)
Brain Metabolic Alterations in Neurodegenerative Diseases
edited by Luciene Bruno Vieira and Fabíola Mara Ribeiro
submission deadline 31 Dec 2025 | 3 articles | Viewed by 13935 | Submission Open
Keywords: glucose metabolism; mitochondrial dysfunction; neuroinflammation; neurodegeneration
(This special issue belongs to the Section Nutrition and Metabolism)
Metabolic Insights into Natural Health Products and Dietary Supplements for Human Health
edited by and Mary Hardy
submission deadline 31 Dec 2025 | 2 articles | Viewed by 10060 | Submission Open
Keywords: bioactive natural compounds; traditional medicine; metabolic pathways; absorption; distribution; metabolism; and excretion (ADME); clinical efficacy; pharmacokinetics; nutritional supplements; health benefits; safety and toxicology; delivery systems
(This special issue belongs to the Section Nutrition and Metabolism)
Lipid Metabolism Disorders in Obesity submission deadline 31 Dec 2025 | 3 articles | Viewed by 4048 | Submission Open
Keywords: fatty liver diseases; overweight and obesity; cardiometabolic risks; lipid metabolism; metabolic syndrome; adipose tissue
(This special issue belongs to the Section Lipid Metabolism)
Harnessing the Power of NMR Metabolomics in Unraveling Metabolic Diseases
edited by and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3997 | Submission Open
Keywords: metabolomics; NMR; precision medicine; translational medicine; metabolic disease
(This special issue belongs to the Section Integrative Metabolomics)
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