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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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LC-MS/MS Analysis for Plant Secondary Metabolites

edited by Tiantian Ye and

Lin Li

submission deadline 20 Sep 2024 | 3 articles | Viewed by 2814 | Submission Open

Keywords: liquid chromatography; mass spectrometry; secondary metabolites; metabolomics; abiotic and biotic stress; plant development

(This special issue belongs to the Section Plant Metabolism)

Proteomics and Metabolomics of Extracellular Vesicles

edited by

Elisabetta Chiaradia

and

Sandra Buratta

submission deadline 20 Sep 2024 | Viewed by 565 | Submission Open

Keywords: extracellular vesicles; proteomics; metabolomic; lipidomic; EV cargo; biomarkers

(This special issue belongs to the Section Cell Metabolism)

Metabolic Cancer Therapy: Targeting Tumor Metabolism for Innovative Adjuvant Treatment

edited by

Raffaele Ivan Cincione

submission deadline 30 Sep 2024 | 3 articles | Viewed by 13608 | Submission Open

Keywords: cancer metabolism; glycolysis; glutaminolysis; ketone bodies; mitochondrial dysfunction

(This special issue belongs to the Section Nutrition and Metabolism)

Lipid Biomarkers and Cardiometabolic Diseases

edited by Hyun Suk Yang

submission deadline 30 Sep 2024 | 5 articles | Viewed by 8656 | Submission Open

Keywords: lipid profiles; lipid metabolism; cholesterol; dietary fat; cardiovascular diseases; metabolic diseases

(This special issue belongs to the Section Lipid Metabolism)

Role of Gut-Derived Metabolites in Health and Disease

edited by

Christoph Trautwein

and

Caterina Lonati

submission deadline 30 Sep 2024 | 3 articles | Viewed by 4374 | Submission Open

Keywords: gut microbiome; host– microbiota interactions; metabolic phenotyping; nutrients; pro- and antibiotics; preclinical and clinical metabolomics; quantitative NMR and MS; MALDI imaging; metabolites; lipids

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics Strategies in Research of Honey Bee Products

edited by

and

submission deadline 30 Sep 2024 | 1 articles | Viewed by 4329 | Submission Open

Keywords: honey bee products; chemical profiles; targeted metabolomics; untargeted metabolomics; biomarkers; authenticity assessment; bioactive compounds; bioactive potential; metabolic perturbations

(This special issue belongs to the Section Food Metabolomics)

Lipid Metabolism and Cardiometabolic Diseases: Latest Advances and Prospects

edited by Melania Gaggini and

Cristina Vassalle

submission deadline 30 Sep 2024 | 2 articles | Viewed by 2993 | Submission Open

Keywords: lipidomic; lipotoxicity; oxidative stress; obesity; dyslipidemia; cardiovascular risk; diabetes; insulin resistance; fatty liver

(This special issue belongs to the Section Lipid Metabolism)

Obesity and Metabolic Syndrome in Children: Insights, Interventions and Emerging Perspectives

edited by

Teofana Otilia Bizerea-Moga

and Wieland Kiess

submission deadline 30 Sep 2024 | 2 articles | Viewed by 1781 | Submission Open

Keywords: metabolic syndrome in children; childhood obesity; hypertension; glucose tolerance; insulin resistance; nutritional status; metabolomics; oxidative stress; trace elements— selenium

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Untargeted Metabolomics and Bacterial Metabolism

edited by Carlos J. García and

Guoqiang Chen

submission deadline 30 Sep 2024 | Viewed by 727 | Submission Open

Keywords: metabolomics; bacteria metabolism

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Novel Concept and Therapeutic Implications of Inborn Errors of Metabolism

edited by

Wladimir Bocca Vieira De Rezende Pinto

Paulo Victor Sgobbi De Souza

, Igor Braga Farias and Roberta Ismael Lacerda MacHado

submission deadline 30 Sep 2024 | Viewed by 492 | Submission Open

Keywords: inborn errors of metabolism; inherited metabolic disorders; neurometabolic disorders; metabolomics; gene therapy; enzyme replacement therapy; nutritional (dietary) therapy; small interfering (siRNA)-based therapy; pharmacological chaperone therapy; bone-marrow-derived stem cell transplantation

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nitrogen Nutrition and Metabolic Aging

edited by

Meihong Xu

submission deadline 30 Sep 2024 | Viewed by 374 | Submission Open

Keywords: bioactive peptides; exogenous nucleotides; nutrition; life-course health; hydrolyzed protein; nitrogen; oligopeptides

(This special issue belongs to the Section Advances in Metabolomics)

Research on Pharmacotherapy of Metabolic-Associated Fatty Liver Disease

edited by Aleksandra Bołdys

submission deadline 30 Sep 2024 | Viewed by 335 | Submission Open

Keywords: liver diseases; metabolomics; metabolic diseases; metabolic dysregulation; targeted therapies; MASLD

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Advances in Food Sciences: Metabolomics to Unravel the Complexity of Food Metabolites

edited by

José Iván Serrano-Contreras

submission deadline 30 Sep 2024 | Viewed by 281 | Submission Open

Keywords: foodomics; nutrimetabolomics; phytochemicals; food chemistry; food analysis; dark matter in diet; nutritional dark matter; nutritional hormesis; untargeted/targeted analysis

(This special issue belongs to the Section Food Metabolomics)

Natural Products and Dietary Supplements in Weight Loss: Metabolomic Perspectives

edited by

Eric Gumpricht

and

Alex Mohr

submission deadline 30 Sep 2024 | Viewed by 258 | Submission Open

Keywords: metabolomics; weight loss; fat loss; nutraceuticals; obesity; natural products; dietary sup-plements; phytochemicals

(This special issue belongs to the Section Integrative Metabolomics)

Metabolism and Immunomodulation in Liver Diseases

edited by

Hanyang Liu

and

Peiyuan Yin

submission deadline 30 Sep 2024 | Viewed by 239 | Submission Open

Keywords: liver diseases; cellular interactions; immunomodulation; hepatic metabolism; hepatic fibrosis; hepatic carcinogenesis; ductular reaction; cell fates; secretome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Future Trends and Emerging Applications in Metabolomics

edited by

Lenard Farczadi

Ionela Hotea

and Chengguo Xing

submission deadline 30 Sep 2024 | Viewed by 202 | Submission Open

Keywords: metabolomics; metabolism; interaction studies; pharmacokinetics; bioavailability; mass spectrometry; bioanalysis; biomarkers; nutrients; animal studies enzymes

(This special issue belongs to the Section Nutrition and Metabolism)

Application of Metabolic Imaging in Cancer Diagnosis and Treatment

edited by Prasanta Dutta

submission deadline 30 Sep 2024 | Viewed by 175 | Submission Open

Keywords: metabolism in cancer; imaging tumor metabolism; hyperpolarized magnetic resonance imaging; positron emission tomography; deuterium metabolic MR imaging; proton spectroscopy; mass spectrometry imaging; NMR metabolomics

(This special issue belongs to the Section Metabolomic Profiling Technology)

Nuclear Magnetic Resonance-Powered Metabolomics: Progress and Future Prospects

edited by Abhinav Dubey

submission deadline 30 Sep 2024 | Viewed by 158 | Submission Open

Keywords: solution-state NMR; metabolism; clinical studies; biomarker discovery; high-throughput data analysis

(This special issue belongs to the Section Advances in Metabolomics)

Harnessing the Power of NMR Metabolomics in Unraveling Metabolic Diseases

edited by

Chi-Jen Lo

and

Mei-Ling Cheng

submission deadline 1 Oct 2024 | 1 articles | Viewed by 1007 | Submission Open

Keywords: metabolomics; NMR; precision medicine; translational medicine; metabolic disease

(This special issue belongs to the Section Integrative Metabolomics)

Metabolites as Biomarkers for Inherited Disorders

edited by Jennifer Saville

submission deadline 4 Oct 2024 | Viewed by 247 | Submission Open

Keywords: biomarkers; metabolites; inherited disorders; diagnostics; metabolomics; lipidomics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Pathways of Nutrition Intake in Obese Children

edited by

Edyta Łuszczki

Katarzyna Dereń

and

Anna Bartosiewicz

submission deadline 5 Oct 2024 | Viewed by 272 | Submission Open

Keywords: children and adolescents; dietary habits; Mediterranean diet; metabolic pathways; metabolic diseases; nutrition; obesity; Western-type diet

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics and Plant Defence

edited by

Shitou Xia

and

Junxing Lu

submission deadline 15 Oct 2024 | 10 articles | Viewed by 17702 | Submission Open

Keywords: metabolomics; plant defense; biotic and abiotic stresses; phytohormone; metabolites and metabolic homeostasis; metabolomic profiling methodology

(This special issue belongs to the Section Plant Metabolism)

Metabolomics and Machine Learning for Improved Diagnostics and as a Tool to Accelerate Drug Development

edited by

Elizabeth O’Day

submission deadline 15 Oct 2024 | 4 articles | Viewed by 5962 | Submission Open

Keywords: metabolomics; machine learning; biomarkers; diagnostics; drug development; NMR; MS; precision medicine; personalized medicine; omics

(This special issue belongs to the Section Metabolomic Profiling Technology)

Effects of Chemical Exposure on Endocrine and Reproductive Functions

edited by Renata Marino Romano and Caroline Serrano-Nascimento

submission deadline 15 Oct 2024 | 2 articles | Viewed by 2112 | Submission Open

Keywords: endocrine-disrupting chemicals exposure impact on metabolic diseases; reproductive failure; infertility; endocrine disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Association between Cardiovascular Events and Metabolic Syndromes

edited by Sung Hea Kim and

Hyeongsu Kim

submission deadline 15 Oct 2024 | 1 articles | Viewed by 744 | Submission Open

Keywords: metabolic syndrome; cardiovascular disease; heart failure; sex difference; age difference

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolites, Neutrophil Metabolism and Effector Functions

edited by Francisco Javier Sánchez-García

submission deadline 15 Oct 2024 | Viewed by 171 | Submission Open

Keywords: innate immunity; infection; neutrophils; metabolism; cell signaling; metabolic microenvironment

(This special issue belongs to the Section Cell Metabolism)

Metabolites and Regenerative Medicine: Perspectives and Updates

edited by Reggiani Vilela Gonçalves, Mariáurea Sarandy and Rômulo Dias Novaes

submission deadline 15 Oct 2024 | Viewed by 171 | Submission Open

Keywords: oxidative stress; inflammasome; cytokines; angiogenesis; tissue repair; molecular biology; cellular and molecu-lar mechanisms; diabetes; tissue repair

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Responses to Environmental Challenges: Insights into Cellular Mechanism and Protective Strategy

edited by

Xiaohua Teng

, Hong Lan,

Lu Kang

and Zan Li

submission deadline 15 Oct 2024 | Viewed by 146 | Submission Open

Keywords: environmental challenge; metabolic response; cellular mechanism; protective strategy; environmental adaptability; oxidative stress; environmental pollution; antioxidant defense; natural compounds; ecosystem protection

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Metabolic Syndrome and Non-alcoholic Liver Disease

edited by

Mircea-Catalin Fortofoiu

and

Luigi Boccuto

submission deadline 20 Oct 2024 | 3 articles | Viewed by 3917 | Submission Open

Keywords: metabolic syndrome; non-alcoholic fatty liver disease (NAFLD); insulin resistance; obesity; type 2 diabetes; liver cirrhosis; dyslipidemia; NAFLD treatment; hepatic steatosis; cardiovascular risk

(This special issue belongs to the Section Lipid Metabolism)

Method Development in Metabolomics and Exposomics

edited by Facundo M. Fernandez

submission deadline 20 Oct 2024 | Viewed by 124 | Submission Open

Keywords: metabolomics; exposomics; lipidomics; metabolite; environmental exposure

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Mass Spectrometry-Based Metabolomics in Health and Disease: Targeted Analysis

edited by Emanuele Porru

submission deadline 25 Oct 2024 | 1 articles | Viewed by 730 | Submission Open

Keywords: mass spectrometry; metabolomics; metabolic diseases; chromatography; biomarkers

(This special issue belongs to the Section Advances in Metabolomics)

Multimodal Approaches to Diagnosing Metabolic Bone Diseases

edited by Simona D’Amore,

Antonio G. Solimando

and Uma Ramaswami

submission deadline 30 Oct 2024 | Viewed by 233 | Submission Open

Keywords: bone disease; bone involvement in congenital and acquired conditions; artificial intelligence; bi-omarker discovery; clinical algorithm; integrated imaging approaches; omics-based approaches

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolites in Ruminant Health

edited by

Diming Wang

submission deadline 31 Oct 2024 | 7 articles | Viewed by 10385 | Submission Open

Keywords: ruminants; health; metabolites

(This special issue belongs to the Section Animal Metabolism)

Meeting the Challenge of Metabolomics Analysis by Using Multidimensional Gas Chromatography with Mass Spectrometry

edited by

Yong Foo Wong

and

Philip J. Marriott

submission deadline 31 Oct 2024 | 3 articles | Viewed by 6897 | Submission Open

Keywords: GC× GC; MDGC; metabolites; high-resolution mass spectrometry; metabolite profiling; metabolite fingerprinting; biomarker; plant secondary compounds; disease diagnosis

(This special issue belongs to the Section Metabolomic Profiling Technology)

Identification and Therapeutic Properties of Secondary Metabolites of Medicinal Plants II

edited by

Marijana Zovko Končić

and

Michał Tomczyk

submission deadline 31 Oct 2024 | 3 articles | Viewed by 5974 | Submission Open

Keywords: antioxidant activity; bioactivity; chromatography; phytochemistry; phytotherapy; plant secondary metabolites; polyphenols

(This special issue belongs to the Section Plant Metabolism)

New Advancements and Challenges in Clinical Metabolomics for Inborn Errors of Metabolism and Rare Diseases

edited by Adam D. Kennedy and

Sarah H. Elsea

submission deadline 31 Oct 2024 | 4 articles | Viewed by 4326 | Submission Open

Keywords: metabolic diseases; rare diseases; clinical metabolomics; genomics; inborn errors of metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mitochondrial Metabolism and Oxidative Stress in Hypertension, Diabetes and Related Complications

edited by

Christian Cortés-Rojo

submission deadline 31 Oct 2024 | 2 articles | Viewed by 1989 | Submission Open

Keywords: diabetes; hypertension; ROS; oxidative stress; cell death; inflammation; mitochondrial control quality; mitochondrial dynamics; mitochondria-targeted molecules; nutraceuticals and functional foods

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Proteomic and Metabolomic Analyses of Fisheries and Aquaculture

edited by

Denise Schrama

submission deadline 31 Oct 2024 | 1 articles | Viewed by 1897 | Submission Open

Keywords: proteomics; metabolomics; aquaculture; fisheries; fish nutrition; fish welfare; fish pathology

(This special issue belongs to the Section Nutrition and Metabolism)

Lipid Metabolism in Obesity and Diabetes, 2nd Edition

edited by

Hajnalka Lőrincz

and

Mariann Harangi

submission deadline 31 Oct 2024 | 1 articles | Viewed by 1881 | Submission Open

Keywords: lipoprotein; lipid metabolism; dyslipidemia; atherosclerosis; obesity; insulin resistance; diabetes; adipokine; hepatokine; oxidative stress; vascular senescence; lipid-lowering treatment; antidiabetic drugs

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Ecotoxicology and Metabolism

edited by Chan Xiong

submission deadline 31 Oct 2024 | 1 articles | Viewed by 610 | Submission Open

Keywords: environmental pollutants; mass spectrometry; biological systems; metallomics; heavy metal metabolism; biochemical pathways; gut microbiota metabolites; environmental metabolites; ecosystem integrity

(This special issue belongs to the Section Environmental Metabolomics)

Insights into Tumor Cell Metabolism and Epigenetics

edited by

Sara Granja

, Vera Miranda-Gonçalves and Filipa Vieira

submission deadline 31 Oct 2024 | Viewed by 304 | Submission Open

Keywords: Warburg effect; epigenetic alterations; metabolic reprogramming; epigenome; transcriptional regula-tion; fatty acid metabolism

(This special issue belongs to the Section Cell Metabolism)

Glucose Metabolism in Cardiovascular Diseases

edited by Hidenori Komiyama and

Kuniya Asai

submission deadline 31 Oct 2024 | Viewed by 168 | Submission Open

Keywords: glucose metabolism; insulin resistance; statin use; mitochondrial function; heart failure; IoT devices; daily activity; skeletal muscle

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Emerging Applications of Urinary Metabolomics in Cancer

edited by

Casey Burton

submission deadline 11 Nov 2024 | Viewed by 268 | Submission Open

Keywords: urinary metabolomics; cancer biomarkers; early cancer detection; analytical method development; therapeutic response monitoring

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Impact of Macronutrients on Metabolism

edited by Janine Wirth

submission deadline 15 Nov 2024 | 5 articles | Viewed by 30988 | Submission Open

Keywords: carbohydrate intake; dietary protein; chronic metabolic response

(This special issue belongs to the Section Nutrition and Metabolism)

Machine Learning in Metabolic Diseases

edited by

Rui Wang-Sattler

submission deadline 15 Nov 2024 | 3 articles | Viewed by 5396 | Submission Open

Keywords: machine learning; supervised; unsupervised; model selection; training and testing; data pre-processing; prediction; identification; validation risk factors/biomarkers; metabolic disease

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Research Progress of Plant Compounds for Diabetes and Its Complications, 2nd Edition

edited by

Cosmin Mihai Vesa

and

Dana Zaha

submission deadline 15 Nov 2024 | Viewed by 698 | Submission Open

Keywords: plant compounds; plant extracts; plant supplement metabolites; diabetes mellitus type 2; diabetic retinopathy; diabetes complications

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomic Advances in Promoting Exercise-Induced Metabolic Changes

edited by

Alex Castro

and Mara Patrıcia Traina Chacon-Mikahi

submission deadline 20 Nov 2024 | 6 articles | Viewed by 9810 | Submission Open

Keywords: metabolome; metabolites; exercise; physical activity; metabolic signatures

(This special issue belongs to the Section Advances in Metabolomics)

Advances in Understanding the Impact of Pregnancy in Inherited Metabolic Disorders

edited by

Gisela Wilcox

submission deadline 20 Nov 2024 | 1 articles | Viewed by 4618 | Submission Open

Keywords: pregnancy; inborn errors of metabolism; inherited metabolic disorders; urea cycle disorders; mitochondrial function; foeto-maternal medicine; fatty acid oxidation; amino acid disorders; phenylketonuria; glycogen storage diseases; lysosomal storage disorders; lactation; postpartum

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment

edited by

Prince Dadson

and

Miikka-Juhani Honka

submission deadline 26 Nov 2024 | Viewed by 215 | Submission Open

Keywords: metabolism; dysmetabolism; tissue-specific metabolism; cardiometabolic disorders; nutritional dis-orders; functional biomarkers; metabolomics profiling; multi-omics data integration; biochemical pathways; personalized medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Plants and Plant-Based Foods for Metabolic Disease Prevention

edited by

Sandra Barbalho

, Rosa Direito,

Adriano Araujo

and Élen Landgraf Guiguer

submission deadline 27 Nov 2024 | Viewed by 272 | Submission Open

Keywords: plants; plant foods; plant-based diet; medicinal plants; inflammation; oxidative stress; inflammatory diseases; metabolic diseases; neurodegenerative diseases

(This special issue belongs to the Section Nutrition and Metabolism)

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