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Membranes
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Recent Studies of Plasma Membranes
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Recent Studies of Plasma Membranes

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membrane Composition and Structures".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 18221

Special Issue Editors

Dr. Paloma Fernandez

E-Mail Website
Guest Editor
Department of Genetics and Cellular Biology, Autonomous University of Madrid, C/ Calle Darwin 2, 28049 Madrid, Spain
Interests: cell biology; alternative methods; toxicology; 3Rs; cell culture
Dr. Ana Peropadre López

E-Mail Website
Guest Editor
Department of Genetics and Cellular Biology, Autonomous University of Madrid, C/ Calle Darwin 2, 28049 Madrid, Spain
Interests: membrane injury; membrane-nanoparticles interactions; cell biology; nanotoxicity

Special Issue Information

Dear Colleagues,

There has been an increasing amount of knowledge regarding the composition and interactions of plasma membranes with other elements, both intracellular (cytoskeleton, peripheric proteins, organelles) and extracellular (signaling molecules, other cells, elements of the extracellular matrix). Thus, the ability of cells to integrate and interpret the information received, generating an appropriate response, is crucial to maintain cell physiology. Considering the complexity of the task, many studies focus on particular aspects of specific cell types, mainly related to the nervous or immunological systems, making it difficult to derive general conclusions. The structural and functional model proposed by Singer and Nicholson has been updated, integrating information related to lipid–lipid and lipid–protein interactions, as well as the primordial role of the cytoskeleton in shaping membrane function.

In this Special Issue on “Recent Studies of Plasma Membranes”, we aim to focus on the common versus particular aspects of plasma membrane organization in different cells, as well as on the mechanisms supported by plasma membranes, such as endo-exocytosis and cell signaling. Special interest is set on how cells maintain plasma membrane homeostasis upon different stimuli.

Authors are welcome to submit original articles or reviews covering any related topic.

Dr. Paloma Fernandez
Dr. Ana Peropadre López
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • membrane structure
  • membrane dynamics
  • membrane repair
  • cell cortex
  • plasma membrane models
  • membrane damage

Published Papers (4 papers)

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Research

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29 pages, 2934 KiB  
Article
Plasma Membrane-Associated Proteins Identified in Arabidopsis Wild Type, lbr2-2 and bak1-4 Mutants Treated with LPSs from Pseudomonas syringae and Xanthomonas campestris
by Benedict C. Offor, Msizi I. Mhlongo, Ian A. Dubery and Lizelle A. Piater
Membranes 2022, 12(6), 606; https://doi.org/10.3390/membranes12060606 - 10 Jun 2022
Cited by 1 | Viewed by 2449
Abstract
Plants recognise bacterial microbe-associated molecular patterns (MAMPs) from the environment via plasma membrane (PM)-localised pattern recognition receptor(s) (PRRs). Lipopolysaccharides (LPSs) are known as MAMPs from gram-negative bacteria that are most likely recognised by PRRs and trigger defence responses in plants. The Arabidopsis PRR(s) [...] Read more.
Plants recognise bacterial microbe-associated molecular patterns (MAMPs) from the environment via plasma membrane (PM)-localised pattern recognition receptor(s) (PRRs). Lipopolysaccharides (LPSs) are known as MAMPs from gram-negative bacteria that are most likely recognised by PRRs and trigger defence responses in plants. The Arabidopsis PRR(s) and/or co-receptor(s) complex for LPS and the associated defence signalling remains elusive. As such, proteomic identification of LPS receptors and/or co-receptor complexes will help to elucidate the molecular mechanisms that underly LPS perception and defence signalling in plants. The Arabidopsis LPS-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI)-related-2 (LBR2) have been shown to recognise LPS and trigger defence responses while brassinosteroid insensitive 1 (BRI1)-associated receptor kinase 1 (BAK1) acts as a co-receptor for several PRRs. In this study, Arabidopsis wild type (WT) and T-DNA knock out mutants (lbr2-2 and bak1-4) were treated with LPS chemotypes from Pseudomonas syringae pv. tomato DC3000 (Pst) and Xanthomonas campestris pv. campestris 8004 (Xcc) over a 24 h period. The PM-associated protein fractions were separated by liquid chromatography and analysed by tandem mass spectrometry (LC-MS/MS) followed by data analysis using ByonicTM software. Using Gene Ontology (GO) for molecular function and biological processes, significant LPS-responsive proteins were grouped according to defence and stress response, perception and signalling, membrane transport and trafficking, metabolic processes and others. Venn diagrams demarcated the MAMP-responsive proteins that were common and distinct to the WT and mutant lines following treatment with the two LPS chemotypes, suggesting contributions from differential LPS sub-structural moieties and involvement of LBR2 and BAK1 in the LPS-induced MAMP-triggered immunity (MTI). Moreover, the identification of RLKs and RLPs that participate in other bacterial and fungal MAMP signalling proposes the involvement of more than one receptor and/or co-receptor for LPS perception as well as signalling in Arabidopsis defence responses. Full article
(This article belongs to the Special Issue Recent Studies of Plasma Membranes)
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15 pages, 5890 KiB  
Article
Trafficking of Annexins during Membrane Repair in Human Skeletal Muscle Cells
by Coralie Croissant, Céline Gounou, Flora Bouvet, Sisareuth Tan and Anthony Bouter
Membranes 2022, 12(2), 153; https://doi.org/10.3390/membranes12020153 - 26 Jan 2022
Cited by 10 | Viewed by 2608
Abstract
Defects in membrane repair contribute to the development of muscular dystrophies, such as Miyoshi muscular dystrophy 1, limb girdle muscular dystrophy (LGMD), type R2 or R12. Deciphering membrane repair dysfunctions in the development of muscular dystrophies requires precise and detailed knowledge of the [...] Read more.
Defects in membrane repair contribute to the development of muscular dystrophies, such as Miyoshi muscular dystrophy 1, limb girdle muscular dystrophy (LGMD), type R2 or R12. Deciphering membrane repair dysfunctions in the development of muscular dystrophies requires precise and detailed knowledge of the membrane repair machinery in healthy human skeletal muscle cells. Using correlative light and electron microscopy (CLEM), we studied the trafficking of four members of the annexin (ANX) family, in myotubes damaged by laser ablation. Our data support a model in which ANXA4 and ANXA6 are recruited to the disruption site by propagating as a wave-like motion along the sarcolemma. They may act in membrane resealing by proceeding to sarcolemma remodeling. On the other hand, ANXA1 and A2 exhibit a progressive cytoplasmic recruitment, likely by interacting with intracellular vesicles, in order to form the lipid patch required for membrane resealing. Once the sarcolemma has been resealed, ANXA1 is released from the site of the membrane injury and returns to the cytosol, while ANXA2 remains accumulated close to the wounding site on the cytoplasmic side. On the other side of the repaired sarcolemma are ANXA4 and ANXA6 that face the extracellular milieu, where they are concentrated in a dense structure, the cap subdomain. The proposed model provides a basis for the identification of cellular dysregulations in the membrane repair of dystrophic human muscle cells. Full article
(This article belongs to the Special Issue Recent Studies of Plasma Membranes)
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Review

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21 pages, 1253 KiB  
Review
The Importance of the Plasma Membrane in Atherogenesis
by Stanislav Kotlyarov and Anna Kotlyarova
Membranes 2022, 12(11), 1036; https://doi.org/10.3390/membranes12111036 - 24 Oct 2022
Cited by 2 | Viewed by 3967
Abstract
Atherosclerotic cardiovascular diseases are an important medical problem due to their high prevalence, impact on quality of life and prognosis. The pathogenesis of atherosclerosis is an urgent medical and social problem, the solution of which may improve the quality of diagnosis and treatment [...] Read more.
Atherosclerotic cardiovascular diseases are an important medical problem due to their high prevalence, impact on quality of life and prognosis. The pathogenesis of atherosclerosis is an urgent medical and social problem, the solution of which may improve the quality of diagnosis and treatment of patients. Atherosclerosis is a complex chain of events, which proceeds over many years and in which many cells in the bloodstream and the vascular wall are involved. A growing body of evidence suggests that there are complex, closely linked molecular mechanisms that occur in the plasma membranes of cells involved in atherogenesis. Lipid transport, innate immune system receptor function, and hemodynamic regulation are linked to plasma membranes and their biophysical properties. A better understanding of these interrelationships will improve diagnostic quality and treatment efficacy. Full article
(This article belongs to the Special Issue Recent Studies of Plasma Membranes)
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16 pages, 1080 KiB  
Review
The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes
by Yolanda Olmos
Membranes 2022, 12(6), 633; https://doi.org/10.3390/membranes12060633 - 19 Jun 2022
Cited by 22 | Viewed by 7670
Abstract
The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III, together with the AAA ATPase VPS4, harbors the [...] Read more.
The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III, together with the AAA ATPase VPS4, harbors the main remodeling and scission function of the ESCRT machinery, whereas early-acting ESCRTs mainly contribute to protein sorting and ESCRT-III recruitment through association with upstream targeting factors. Here, we review recent advances in our understanding of the molecular mechanisms that underlie membrane constriction and scission by ESCRT-III and describe the involvement of this machinery in the sealing and repairing of damaged cellular membranes, a key function to preserve cellular viability and organellar function. Full article
(This article belongs to the Special Issue Recent Studies of Plasma Membranes)
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