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Membranes
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Membranes for Tissue Engineering and Clinical Applications
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Membranes for Tissue Engineering and Clinical Applications

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Membrane Applications".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 5993

Special Issue Editors

Prof. Dr. Po-Chun Chang

E-Mail Website
Guest Editor
Graduate Institute of Clinical Dentistry, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan
Interests: tissue engineering; periodontology and implantology; biomaterials; nanotechnology; bioprinting technology; stem cells; clinical trials
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ming-Hua Ho

E-Mail Website
Guest Editor
Department of Chemical Engineering, College of Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
Interests: biomaterials; drug delivery; nano-materials;photo-polymers for 3D printing; bio-interface

Special Issue Information

Dear Colleagues,

An adequate scaffold plays a crucial role in the applications of tissue engineering and regenerative medicine. A plethora of biomaterials, both naturally derived and synthetic, has been introduced to engineer novel scaffolds in recent decades. To serve as a scaffold for tissue regeneration, the membrane should exhibit adequate biocompatibility and biodegradability, sufficient mechanical stability, and an extracellular matrix-like interface mimicking physiological cell–matrix interactions.

Membrane-based scaffolds have been widely utilized for bone, cartilage, nerve, skin, and vascular tissue engineering. Membranes have also been used as effective topical or transdermal drug carriers to deliver antibiotics to infected wounds or insulin for diabetic treatment, and as barriers to exclude unwanted cells for guided tissue/bone regeneration. To properly modulate cellular behavior, modern manufacturing technologies and interface designs to establish a biomimetic or functionalized interface are required. Numerous efforts also concentrate on the incorporation of cells and/or molecular signals to facilitate the outcome of regeneration.

The recent development of bioengineered constructs including cell sheets, decellularized scaffolds, and synthetic membranes has shown great potential in reconstructing damaged or diseased membranous structures (e.g., tympanic membrane, retina, and cornea). Additionally, naturally derived membranes, such as human amniotic membrane, have been applied as grafts, dressings, and scaffolds and shown a substantial benefit in regenerative medicine.

In this Special Issue, we aim to focus on the latest developments of membrane systems for tissue engineering applications and clinical validations of the membrane-based approaches. Potential topics include but are not limited to the following:

  • Advanced technologies in membrane manufacturing or characterization;
  • Membranes for drug or biomolecule delivery;
  • Naturally derived membranes (e.g., amniotic membrane) for biomedical application;
  • Functionalization or modification on the available membranes;
  • Bioprinted or cell-laden membranes;
  • Cell–membrane or tissue–membrane interactions;
  • Barrier membranes for guided tissue/bone regeneration;
  • Bioengineered constructs for regenerating membranous structures (e.g., tympanic membrane, retina, and cornea).

Authors are invited to submit their latest original articles and reviews to advance our knowledge.

Prof. Dr. Po-Chun Chang
Prof. Dr. Ming-Hua Ho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering scaffold
  • drug delivery system
  • synthetic membrane
  • naturally derived membrane
  • cell-laden and biomolecules-loaded membrane
  • bioengineered construct
  • guided tissue regeneration
  • cell–matrix interaction
  • clinical trials

Published Papers (2 papers)

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Research

15 pages, 5788 KiB  
Article
One-Step Fabrication of Porous Membrane-Based Scaffolds by Air-Water Interfacial Phase Separation: Opportunities for Engineered Tissues
by Iris Allijn, Nikola du Preez, Małgorzata Tasior, Ruchi Bansal and Dimitrios Stamatialis
Membranes 2022, 12(5), 453; https://doi.org/10.3390/membranes12050453 - 23 Apr 2022
Cited by 5 | Viewed by 2002
Abstract
Common methods for fabricating membrane-based scaffolds for tissue engineering with (hydrophobic) polymers include thermal or liquid-phase inversion, sintering, particle leaching, electrospinning and stereolithography. However, these methods have limitations, such as low resolution and pore interconnectivity and may often require the application of high [...] Read more.
Common methods for fabricating membrane-based scaffolds for tissue engineering with (hydrophobic) polymers include thermal or liquid-phase inversion, sintering, particle leaching, electrospinning and stereolithography. However, these methods have limitations, such as low resolution and pore interconnectivity and may often require the application of high temperatures and/or toxic porogens, additives or solvents. In this work, we aim to overcome some of these limitations and propose a one-step method to produce large porous membrane-based scaffolds formed by air-water interfacial phase separation using water as a pore-forming agent and casting substrate. Here, we provide proof of concept using poly (trimethylene carbonate), a flexible and biocompatible hydrophobic polymer. Membrane-based scaffolds were prepared by dropwise addition of the polymer solution to water. Upon contact, rapid solvent–non-solvent phase separation took place on the air-water interface, after which the scaffold was cured by UV irradiation. We can tune and control the morphology of these scaffolds, including pore size and porosity, by changing various parameters, including polymer concentration, solvent type and temperature. Importantly, human hepatic stellate cells cultured on these membrane-based scaffolds remained viable and showed no signs of pro-inflammatory stress. These results indicate that the proposed air-water interfacial phase separation represents a versatile method for creating porous membrane-based scaffolds for tissue engineering applications. Full article
(This article belongs to the Special Issue Membranes for Tissue Engineering and Clinical Applications)
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11 pages, 1073 KiB  
Article
Radiographic Evaluation of Regeneration Strategies for the Treatment of Advanced Mandibular Furcation Defects: A Retrospective Study
by Hsiang-Ling Huang, Yun-Han Ma, Che-Chang Tu and Po-Chun Chang
Membranes 2022, 12(2), 219; https://doi.org/10.3390/membranes12020219 - 14 Feb 2022
Cited by 6 | Viewed by 3272
Abstract
Teeth with furcation involvement (FI) present a higher risk of loss and are difficult to maintain. This study evaluated the efficacy of furcation defect regeneration (FDR) as a regeneration strategy. Pre-operative and 6-month postoperative radiographs were collected from patients receiving regeneration therapy for [...] Read more.
Teeth with furcation involvement (FI) present a higher risk of loss and are difficult to maintain. This study evaluated the efficacy of furcation defect regeneration (FDR) as a regeneration strategy. Pre-operative and 6-month postoperative radiographs were collected from patients receiving regeneration therapy for mandibular teeth with degree II and early degree III FI. The linear furcation involvement (LFI), ratio of LFI (RLI), LFI and RLI adjusted bythe alveolar bone crest (ABC), and radiographic intensity were assessed. The effects of demographic characteristics, regeneration treatment strategies, the relationship between furcation and ABC, and adjacent intrabony defect regeneration (AIDR) were evaluated using a generalized linear model and logistic regression. The results demonstrated that 1.5 mm adjusted LFI and 40% adjusted RLI were achieved in both pure furcation defects and combined furcation–angular defects by the combination of bone replacement grafts (BRG) and enamel matrix derivatives (EMD) or collagen membrane (CM); deproteinized bovine bone matrix (DBBM) showed a superior outcome among BRG. In combined furcation–angular defects, EMD appeared more beneficial than CM, and AIDR significantly promoted adjusted LFI and RLI. In conclusion, DBBM with EMD or CM was effective for FDR, and AIDR had a positive effect on FDR in the combined furcation–angular defect. Full article
(This article belongs to the Special Issue Membranes for Tissue Engineering and Clinical Applications)
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