CD20 in Disease Therapy

Dear Colleagues,

CD20 is a non-glycosylated transmembrane protein expressed on a variety of B-cells from the pre-B-cell stage to mature/memory B cells, but not plasma cells. CD20 mAb against human CD20 induce rapid B-cell depletion and is currently approved by the Food and Drug Administration (FDA) for treatment of non-Hodgkin B-cell lymphomas and several autoimmune disorders including type I diabetes (T1D), rheumatoid arthritis, and Sjogren’s syndrome (SS). The immediate short- or prolonged-action mechanisms of anti-CD20 in depleting B-cells are through the direct induction of apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and complement-dependent lysis (CDC) which are used for immunotherapy, immunization effect as well as immune tolerance applications. As CD20 mAb becomes involved in broad aspects of disease therapies and immunomodulation, understanding the detailed functions as well as their subsequent mechanisms will provide insights into the development of translational applications. Primary research manuscripts or review articles related to various aspects of CD20 mAb in therapies are invited for this Special Issue.

Dr. Chao lien Liu
Guest Editor

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