Special Issue "Marine Dinoflagellates"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (30 June 2014)
Dr. Andrea Bourdelais
Center for Marine Science, University of North Carolina at Wilmington, 5600 Marvin K. Moss Lane, Wilmington NC, 28409, USA
Fax: +1 910 962 2410
Interests: isolation and structure elucidation of bioactive marine natural products; polyether compounds; bioassay screening; high content screening; quantitative analysis of marine toxins; harmful algal blooms; Florida red tide; marine dinoflagellates
Dinoflagellates comprise a diverse class of flagellated protists found in marine and fresh water environments. Of the approximately 2000 living species about 1700 species are found in marine environments. Due to the complex nature of the marine environment these microorganisms have developed unique biosynthetic machinery for the production of metabolites with unusual chemical structures and potent biological activities. Naturally produced chemical families include polyethers, macrolides, polyhydroxy compounds, heterocycles, polyketals, amino acids, terpenes, phytopigments, and purine derivatives. Although metabolites produced by these micro-organisms are known for their cytotoxicity, many have show selective activity in biological systems for example: saxitoxins are selective sodium channel blockers, brevetoxins and ciguatoxins selectively activate sodium channels, and maitotoxins act on calcium channels. Other metabolites have been found to inhibit enzymes (okadaic acid), yet others have show potent activity as anti-fungal (gamberic acids) or anti-tumor (amphidinols) agents. Because of their unprecedented biosynthetic capabilities and ease of culture, dinoflagellates provide a renewable source for novel chemical structures that may be used as biological tools or drug candidates. This special issue will be devoted to the bioactivity of both natural and chemically modified dinoflagellate metabolites as well the biosynthetic pathways involved in their production.
Dr. Andrea J. Bourdelais
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed Open Access monthly journal published by MDPI.
- marine natural products
- bioactive metabolites
- mechanism of action
- therapeutic potential
- marine toxins
- bioactive compounds
- symbiotic relationships
- natural defenses
- semisynthetic derivatives
- structure activity relationships
- environmental impact