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Special Issue "Ion Channel Inhibiting Marine Toxins"

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A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 October 2010)

Special Issue Editor

Guest Editor
Prof. Dr. Peter C. Ruben (Website)

Department of Biomedical Physiology & Kinesiology, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada
Fax: +1 778 782 3040
Interests: voltage-gated ion channels; toxins; evolution

Special Issue Information

Dear Colleagues,

Ion channels are important targets for therapeutic drugs. A wide range of diseases and disorders stem from ion channel dysfunction. The oceans are a source of toxins that have effects known to inhibit ion channels; many more drugs of therapeutic significance may yet be found within the oceans’ depths. Some marine toxins are already recognized for their great potential to treat, for example, neuropathic pain through their inhibition and blockade of voltage-gated ion channels. As more marine toxins become purified and tested for their effects on ion channels, more applications will inevitably be discovered that have important medical ramifications.
This special issue of Marine Drugs is dedicated to toxins that inhibit ion channels, and seeks to emphasize the importance of channel-inhibiting toxins as potential therapeutic agents and as research tools. It is my honor to serve as Guest Editor for this special issue, and to invite scientists to report recent advances or review the recent literature on the full spectrum of research questions associated with toxins that inhibit ion channels. I eagerly anticipate working with you towards a successful special issue of Marine Drugs focused upon channel-inhibiting marine toxins. On behalf of the journal, I hope this special issue becomes a vehicle for the latest developments in this exciting and important research area.

Dr. Peter C. Ruben
Guest Editor

Keywords

  • voltage-gated ion channels
  • ligand-gated ion channels
  • receptors
  • blockade
  • inhibition
  • marine toxins
  • venom
  • antagonist

Published Papers (1 paper)

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Research

Open AccessArticle Screening and cDNA Cloning of Kv1 Potassium Channel Toxins in Sea Anemones
Mar. Drugs 2010, 8(12), 2893-2905; doi:10.3390/md8122893
Received: 2 November 2010 / Revised: 19 November 2010 / Accepted: 1 December 2010 / Published: 2 December 2010
Cited by 14 | PDF Full-text (421 KB) | HTML Full-text | XML Full-text
Abstract
When 21 species of sea anemones were screened for Kv1 potassium channel toxins by competitive inhibition of the binding of 125I-α-dendrotoxin to rat synaptosomal membranes, 11 species (two species of Actiniidae, one species of Hormathiidae, five species of Stichodactylidae and three [...] Read more.
When 21 species of sea anemones were screened for Kv1 potassium channel toxins by competitive inhibition of the binding of 125I-α-dendrotoxin to rat synaptosomal membranes, 11 species (two species of Actiniidae, one species of Hormathiidae, five species of Stichodactylidae and three species of Thalassianthidae) were found to be positive. Furthermore, full-length cDNAs encoding type 1 potassium channel toxins from three species of Stichodactylidae and three species of Thalassianthidae were cloned by a combination of RT-PCR, 3′RACE and 5′RACE. The precursors of these six toxins are commonly composed of signal peptide, propart and mature peptide portions. As for the mature peptide (35 amino acid residues), the six toxins share more than 90% sequence identities with one another and with κ1.3-SHTX-She1a (Shk) from Stichodactyla helianthus but only 34–63% identities with the other type 1 potassium channel toxins. Full article
(This article belongs to the Special Issue Ion Channel Inhibiting Marine Toxins)
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marinedrugs@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
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