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Special Issue "Bioactive Compounds from Mangroves and Their-Associated Microbes"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 March 2018

Special Issue Editor

Guest Editor
Prof. Dr. Hee Jae Shin

Korea Institute of Ocean Science and Technology, Marine Natural Products Laboratory, 787 Haeanro, Ansan 426-744, Korea
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Interests: isolation and characterization of marine natural products; drug discovery; anti-cancer compounds; anti-inflammatory compounds, anti-microbial compounds

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to demonstrate the importance of some mangroves and mangrove-derived microbes as a source of novel compounds.

Endophytic microbes, such as fungi, bacteria, and actinomycetes, can produce a variety of natural products, which are structurally unique and possess interesting biological and pharmacological activities. Owing to the specific ecological circumstances of mangroves, related endophytes have to cope with both terrestrial and marine environments, resulting in a great microbial diversity and metabolism specificity.

This Special Issue will focus on the recent research progresses in these interrelated disciplines. As a Guest Editor for this Special Issue of Marine Drugs, I invite you to submit your research findings on the mangroves and mangrove-associated microbes including those from the mangrove sediment ranging from the isolation and structure elucidation of new marine natural products to the mechanism studies of the novel bioactive compounds in this area.

Prof. Dr. Hee Jae Shin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mangroves
  • mangrove-associated microorganisms
  • endophytic microbes
  • mangrove-derived microbial metabolic diversity
  • marine microorganisms
  • marine pharmaceuticals
  • novel therapeutic agents
  • bioactive compounds
  • marine natural products

Published Papers (1 paper)

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Research

Open AccessArticle Twenty-Nine New Limonoids with Skeletal Diversity from the Mangrove Plant, Xylocarpus moluccensis
Mar. Drugs 2018, 16(1), 38; doi:10.3390/md16010038
Received: 11 December 2017 / Revised: 10 January 2018 / Accepted: 17 January 2018 / Published: 19 January 2018
PDF Full-text (5823 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Twenty-nine new limonoids—named xylomolins A1–A7, B1–B2, C1–C2, D–F, G1–G5, H–I, J1–J2, K1–K2, L1–L2, and M–N,
[...] Read more.
Twenty-nine new limonoids—named xylomolins A1–A7, B1–B2, C1–C2, D–F, G1–G5, H–I, J1–J2, K1–K2, L1–L2, and M–N, were isolated from the seeds of the mangrove plant, Xylocarpus moluccensis. Compounds 113 are mexicanolides with one double bond or two conjugated double bonds, while 14 belongs to a small group of mexicanolides with an oxygen bridge between C1 and C8. Compounds 1519 are khayanolides containing a Δ8,14 double bond, whereas 20 and 21 are rare khayanolides containing a Δ14,15 double bond and Δ8,9, Δ14,15 conjugated double bonds, respectively. Compounds 22 and 23 are unusual limonoids possessing a (Z)-bicyclo[5.2.1]dec-3-en-8-one motif, while 24 and 25 are 30-ketophragmalins with Δ8,9, Δ14,15 conjugated double bonds. Compounds 26 and 27 are phragmalin 8,9,30-ortho esters, whereas 28 and 29 are azadirone and andirobin derivatives, respectively. The structures of these compounds, including absolute configurations of 1519, 2123, and 26, were established by HRESIMS, extensive 1D and 2D NMR investigations, and the comparison of experimental electronic circular dichroism (ECD) spectra. The absolute configuration of 1 was unequivocally established by single-crystal X-ray diffraction analysis, obtained with Cu Kα radiation. The diverse cyclization patterns of 129 reveal the strong flexibility of skeletal plasticity in the limonoid biosynthesis of X. moluccensis. Compound 23 exhibited weak antitumor activity against human triple-negative breast MD-MBA-231 cancer cells with an IC50 value of 37.7 μM. Anti-HIV activities of 1, 3, 8, 10, 11, 14, 20, 2325, and 27 were tested in vitro. However, no compounds showed potent inhibitory activity. Full article
(This article belongs to the Special Issue Bioactive Compounds from Mangroves and Their-Associated Microbes)
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