Next Article in Journal
Terpenoids from Marine Soft Coral of the Genus Lemnalia: Chemistry and Biological Activities
Previous Article in Journal
The Bisindole Alkaloid Caulerpin, from Seaweeds of the Genus Caulerpa, Attenuated Colon Damage in Murine Colitis Model
Previous Article in Special Issue
New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54
Article Menu

Export Article

Open AccessReview
Mar. Drugs 2018, 16(9), 319; https://doi.org/10.3390/md16090319

Lead Compounds from Mangrove-Associated Microorganisms

Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse 1, 40225 Düsseldorf, Germany
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 7 August 2018 / Revised: 22 August 2018 / Accepted: 29 August 2018 / Published: 7 September 2018
(This article belongs to the Special Issue Bioactive Compounds from Mangroves and Their-Associated Microbes)
Full-Text   |   PDF [10466 KB, uploaded 7 September 2018]   |  

Abstract

The mangrove ecosystem is considered as an attractive biodiversity hotspot that is intensively studied in the hope of discovering new useful chemical scaffolds, including those with potential medicinal application. In the past two decades, mangrove-derived microorganisms, along with mangrove plants, proved to be rich sources of bioactive secondary metabolites as exemplified by the constant rise in the number of publications, which suggests the great potential of this important ecological niche. The present review summarizes selected examples of bioactive compounds either from mangrove endophytes or from soil-derived mangrove fungi and bacteria, covering the literature from 2014 to March 2018. Accordingly, 163 natural products are described in this review, possessing a wide range of potent bioactivities, such as cytotoxic, antibacterial, antifungal, α-glucosidase inhibitory, protein tyrosine phosphatase B inhibitory, and antiviral activities, among others. View Full-Text
Keywords: mangrove microorganisms; bioactive natural products; endophytes; drug leads mangrove microorganisms; bioactive natural products; endophytes; drug leads
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ancheeva, E.; Daletos, G.; Proksch, P. Lead Compounds from Mangrove-Associated Microorganisms. Mar. Drugs 2018, 16, 319.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top