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Marine Drugs
Special Issues
Bioactive Compounds from Soft Corals and Their Derived Microorganisms
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Bioactive Compounds from Soft Corals and Their Derived Microorganisms

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 4044

Special Issue Editor

Dr. Yan-Bo Zeng

E-Mail Website
Guest Editor
Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Interests: natural product chemistry; bioactive compounds; drug discovery; structure determination

Special Issue Information

Dear Colleagues,                

The ocean provides a vast array of habitats for various living organisms. In order to survive in extreme environments, marine organisms have to produce highly potent metabolites. Among marine organisms, soft corals are promising providers of marine bioactive compounds and have received increasing attention. Over the past few decades, a fairly large variety of bioactive secondary metabolites including terpenoids, diterpenoids, sesquiterpenoids, steroids, quinones, prostaglandins, ceramides, and other chemical compounds have been discovered in soft corals, which exhibit a spectrum of biological activities, such as antimicrobial, anti-angiogenic, anticancer, immunomodulatory, anti-inflammatory, antiviral, and antifouling activities.

This Special Issue focuses on bioactive compounds derived from marine soft corals and their derived microorganisms and offers researchers the opportunity to publish original work on various topics including, but not limited to, the following:

  1. Isolation, structure elucidation, and bioactivity of compounds from soft corals and their derived microorganisms;
  2. Characterization of proteins, enzymes, and saccharides from soft corals and their derived microorganisms;
  3. Design, synthesis, modification, and structure–activity relationship of the abovementioned compounds.

Dr. Yan-Bo Zeng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • soft corals
  • soft coral-derived microorganisms
  • marine natural products
  • bioactive compounds
  • chemical structures
  • biosynthetic pathway
  • pharmacological mechanism

Published Papers (4 papers)

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Research

13 pages, 1518 KiB  
Article
Marine Prostanoids with Cytotoxic Activity from Octocoral Clavularia spp.
by Ming-Ya Cheng, I-Chi Hsu, Shi-Ying Huang, Ya-Ting Chuang, Tzi-Yi Ke, Hsueh-Wei Chang, Tian-Huei Chu, Ching-Yeu Chen and Yuan-Bin Cheng
Mar. Drugs 2024, 22(5), 219; https://doi.org/10.3390/md22050219 - 14 May 2024
Viewed by 168
Abstract
Octocoral of the genus Clavularia is a kind of marine invertebrate possessing abundant cytotoxic secondary metabolites, such as prostanoids and dolabellanes. In our continuous natural product study of C. spp., two previously undescribed prostanoids [clavulone I-15-one (1) and 12-O-deacetylclavulone [...] Read more.
Octocoral of the genus Clavularia is a kind of marine invertebrate possessing abundant cytotoxic secondary metabolites, such as prostanoids and dolabellanes. In our continuous natural product study of C. spp., two previously undescribed prostanoids [clavulone I-15-one (1) and 12-O-deacetylclavulone I (2)] and eleven known analogs (3–13) were identified. The structures of these new compounds were elucidated based on analysis of their 1D and 2D NMR, HRESIMS, and IR data. Additionally, all tested prostanoids (1 and 3–13) showed potent cytotoxic activities against the human oral cancer cell line (Ca9-22). The major compound 3 showed cytotoxic activity against the Ca9-22 cells with the IC50 value of 2.11 ± 0.03 μg/mL, which echoes the cytotoxic effect of the coral extract. In addition, in silico tools were used to predict the possible effects of isolated compounds on human tumor cell lines and nitric oxide production, as well as the pharmacological potentials. Full article
(This article belongs to the Special Issue Bioactive Compounds from Soft Corals and Their Derived Microorganisms)
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10 pages, 4593 KiB  
Article
New Diterpenes and Diterpene Glycosides with Antibacterial Activity from Soft Coral Lemnalia bournei
by Xiao Han, Huiting Wang, Bing Li, Xiaoyi Chen, Te Li, Xia Yan, Han Ouyang, Wenhan Lin and Shan He
Mar. Drugs 2024, 22(4), 157; https://doi.org/10.3390/md22040157 - 29 Mar 2024
Viewed by 1047
Abstract
Five new biflorane-type diterpenoids, biofloranates E–I (1–5), and two new bicyclic diterpene glycosides, lemnaboursides H–I (6–7), along with the known lemnabourside, were isolated from the South China Sea soft coral Lemnalia bournei. Their chemical [...] Read more.
Five new biflorane-type diterpenoids, biofloranates E–I (1–5), and two new bicyclic diterpene glycosides, lemnaboursides H–I (6–7), along with the known lemnabourside, were isolated from the South China Sea soft coral Lemnalia bournei. Their chemical structures and stereochemistry were determined based on extensive spectroscopic methods, including time-dependent density functional theory (TDDFT) ECD calculations, as well as a comparison of them with the reported values. The antibacterial activities of the isolated compounds were evaluated against five pathogenic bacteria, and all of these diterpenes and diterpene glycosides showed antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 4 to 64 µg/mL. In addition, these compounds did not exhibit noticeable cytotoxicities on A549, Hela, and HepG2 cancer cell lines, at 20 μM. Full article
(This article belongs to the Special Issue Bioactive Compounds from Soft Corals and Their Derived Microorganisms)
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11 pages, 2179 KiB  
Article
Lemneolemnanes A–D, Four Uncommon Sesquiterpenoids from the Soft Coral Lemnalia sp.
by Yuan Zong, Tian-Yun Jin, Jun-Jie Yang, Kun-Ya Wang, Xing Shi, Yue Zhang and Ping-Lin Li
Mar. Drugs 2024, 22(4), 145; https://doi.org/10.3390/md22040145 - 26 Mar 2024
Viewed by 872
Abstract
Four undescribed sesquiterpenoids, lemneolemnanes A–D (1–4), have been isolated from the marine soft coral Lemnalia sp. The absolute configurations of the stereogenic carbons of 1–4 were determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 are [...] Read more.
Four undescribed sesquiterpenoids, lemneolemnanes A–D (1–4), have been isolated from the marine soft coral Lemnalia sp. The absolute configurations of the stereogenic carbons of 1–4 were determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 are epimers at C-3 and have an unusual skeleton with a formyl group on C-6. Compound 3 possesses an uncommonly rearranged carbon skeleton, while 4 has a 6/5/5 tricyclic system. Compound 1 showed significant anti-Alzheimer’s disease (AD) activity in a humanized Caenorhabditis elegans AD pathological model. Full article
(This article belongs to the Special Issue Bioactive Compounds from Soft Corals and Their Derived Microorganisms)
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16 pages, 4884 KiB  
Article
In Vitro Insights into the Role of 7,8-Epoxy-11-Sinulariolide Acetate Isolated from Soft Coral Sinularia siaesensis in the Potential Attenuation of Inflammation and Osteoclastogenesis
by Lin-Mao Ke, Dan-Dan Yu, Ming-Zhi Su, Liao Cui and Yue-Wei Guo
Mar. Drugs 2024, 22(2), 95; https://doi.org/10.3390/md22020095 - 19 Feb 2024
Viewed by 1358
Abstract
The balance between bone-resorbing osteoclasts and bone-forming osteoblasts is essential for the process of bone remodeling. Excessive osteoclast differentiation plays a pivotal role in the pathogenesis of bone diseases such as rheumatoid arthritis and osteoporosis. In the present study, we examined whether 7,8-epoxy-11-sinulariolide [...] Read more.
The balance between bone-resorbing osteoclasts and bone-forming osteoblasts is essential for the process of bone remodeling. Excessive osteoclast differentiation plays a pivotal role in the pathogenesis of bone diseases such as rheumatoid arthritis and osteoporosis. In the present study, we examined whether 7,8-epoxy-11-sinulariolide acetate (Esa), a marine natural product present in soft coral Sinularia siaesensis, attenuates inflammation and osteoclastogenesis in vitro. The results indicated that Esa significantly inhibited lipopolysaccharide (LPS)-induced inflammation model of RAW264.7 cells and suppressed receptor activator for nuclear factor-κB ligand (RANKL)-triggered osteoclastogenesis. Esa significantly down-regulated the protein expression of iNOS, COX-2, and TNF-α by inhibiting the NF-κB/MAPK/PI3K pathways and reducing the release of reactive oxygen species (ROS) in RAW264.7 macrophages. Besides, Esa treatment significantly inhibited osteoclast differentiation and suppressed the expression of osteoclast-specific markers such as NFATC1, MMP-9, and CTSK proteins. These findings suggest that Esa may be a potential agent for the maintenance of bone homeostasis associated with inflammation. Full article
(This article belongs to the Special Issue Bioactive Compounds from Soft Corals and Their Derived Microorganisms)
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