Clinical Science and Personalized Laboratory Medicine

Dear Colleagues,

Clinicians use laboratory test results for diagnosis, monitoring, screening, case finding, planning, and treatment evaluation, and consequently, they usually make clinical decisions based on laboratory test results. For clinical decisions, clinicians compare patients’ test results to cutoff limits or reference data; however, these cutoff limits or reference data are derived from population-based studies, and therefore, individuals are considered as members of the population rather than as individuals. Furthermore, many commonly requested analytes show marked individuality; therefore, the cutoff limits or data derived from population studies may not be reliable for individuals.

Various factors such as sex, age, ethnicity, epigenetic changes, genetic characteristics, nutritional status, and environmental exposure make up and characterize individuals. Because everyone is unique at the behavioral, physiological, and molecular levels, the clinical findings and development of diseases will vary among individuals. Therefore, the diagnosis and treatment of diseases should be individualized.

Personalized laboratory medicine is an essential part of personalized medicine that is based on changes in the biomarker profiles characterizing an individual status, rather than changes in the concentration of a single biomarker; therefore, the success of personalized laboratory medicine depends on the use of advanced omics (such as genomics, proteomics, transcriptomics, metabolomics, epigenomics, pharmaco-genomics, etc.) technologies to create the molecular profiles of individuals and the availability of relevant and reliable personalized reference intervals.

Through this Special Issue, we invite researchers to contribute papers that present novel findings across all aspects of “Personalized Laboratory Medicine”. The aim is to collect the latest research/review manuscripts related to personalized laboratory medicine, integrating personalized laboratory medicine with personalized clinical sciences to facilitate a personalized approach to diseases from diagnosis to treatment.

Dr. Abdurrahman Coskun
Dr. Ali Zarrabi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.