Advances in Pituitary Adenomas

Dear Colleagues,

Pituitary adenoma (PA) is a tumour of which the growth can eventually press on nearby structures, spread to surrounding tissue and cause symptoms due to the metabolic consequences of excessive hormone secretion. Patients suffer from headaches, changes in vision or endocrine disorders such as infertility, reduced libido and galactorrhoea. Surgical intervention, especially in the form of transsphenoidal surgery, is the preferred initial treatment for PAs. However, it should be noted that despite surgical resection as the primary treatment, recurrence can occur in up to one third of the cases, affecting both non-functional and functional adenomas. The exact cause of PA is unknown, and its pathogenesis is considered multifactorial, including changes at the molecular level leading to different clinical manifestations of PA.

The aim of this Special Issue is to thoroughly investigate the underlying mechanisms and clinical characteristics of PA onset and progression, offering deliberations regarding the complexities surrounding its diagnosis, management and treatment.

By shedding light on the pathogenic complexities, this Special Issue endeavours to promote discussions aimed at pinpointing knowledge gaps in PA tumorigenesis requiring additional research at different clinicopathological levels.

Dr. Brigita Glebauskienė
Dr. Alvita Vilkevičiūtė
Prof. Dr. Rasa Liutkevičienė
Guest Editors

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• pituitary adenoma
• biomarkers
• visual functions
• recurrence
• invasiveness
• diagnosis and treatment
• clinical insights
• development