New Advances in Prenatal Diagnosis and Newborn Screening

Dear Colleagues,

An increasing amount of evidence points to the pivotal role of proangiogenic, angiogenic, immunological and inflammatory factors in fetoplacental growth and development. These factors are produced by different cell types of the placenta (extravillous and intravillous trophoblasts, amniotic and chorionic cells, natural killer cells, T lymphocytes, macrophages, etc.) and accumulate in different fetomaternal body fluid compartments. The levels of these factors are different in various pathological conditions of the pregnancy and are capable of predicting pregnancy outcomes, pathological conditions of the pregnancy, and may interrelate with intrauterine sonographic and birth parameters.

Growing knowledge about the overproduction or underproduction of these factors helps us to understand the etiology and pathomechanisms of disorders, including preeclampsia, pregestational and gestational diabetes, and growth alterations of fetuses, which will contribute to the improvement of perinatal outcomes and reduce maternal and neonatal mortality.

The aim of this Special Issue is to provide an overview of new molecular pathways and serological and sonographic markers for the etiopathogenesis of pathological conditions in pregnancies. We encourage laboratory and clinical researchers to submit their works that contribute to the improvement of pregnancy outcomes in pathological conditions of pregnancies. Thus, all original research articles or reviews on topics related to pregnancy complications are welcome in this Special Issue.

Topics will comprise:

Complications of pregnancy: fetal growth restriction, large for gestational age, pregestational and gestational diabetes, preeclampsia and hypertension in pregnant women, molecular markers, etiopathogenesis, pathophysiology, causes, and complications.

Neonatal condition, i.e., small for gestational age or large for gestational age.

Placenta and amniotic fluid in pathological conditions of pregnancy: what is pathognomonic in different conditions?

Fetal and neonatal complications.

Dr. Zoltan Kozinszky
Dr. Andrea Suranyi
Guest Editors

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• sonographic parameters
• molecular markers
• extravillous and villous trophoblasts
• perinatal ultrasound
• serum markers for complications of pregnancy
• histopathology of the placenta
• neonatal pathological conditions