Knee Osteoarthritis: Clinical Updates and Perspectives

Dear Colleagues,

I'm excited to announce that I will be serving as the Guest Editor for the upcoming Special Issue titled "Knee Osteoarthritis: Clinical Updates and Perspectives". I believe that the ultimate goal in the treatment of knee osteoarthritis is to extend the "healthy lifespan." There are diverse approaches to achieve this goal.

From a preventive standpoint, lifestyle improvements such as diet and exercise are crucial. Approaching populations at a higher risk of developing knee osteoarthritis in the future, considering genetic and anatomical factors, represents a novel concept. Additionally, knee-preserving osteotomies aiming for "joint preservation" have seen significant progress in recent years.

In the field of biotherapy, cell therapies using autologous platelet-rich plasma and mesenchymal stem cells, as well as treatments utilizing liquid factors such as extracellular vesicles and exosomes, have undergone explosive development. However, when considering the goal of extending a healthy lifespan, it is essential not to persist in conservative treatments unnecessarily but to perform joint replacement surgery at the appropriate time.

In the complex realm of knee joint care, where the causes of pain are intricate, the most crucial premise is to thoroughly assess the patient's physical condition and, in conjunction with imaging diagnostics, appropriately evaluate the causes of pain for effective intervention.

For this Special Issue, I aim to gather insights from specialists at the forefront of these clinical updates and perspectives. Contributions are welcomed from clinical research, basic research with clinical relevance, animal experiments, literature reviews or any other relevant fields. I encourage submissions that share cutting-edge knowledge aimed at extending the healthy lifespan of patients.

Dr. Yoshitomo Saita
Dr. Shinnosuke Hada
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• knee osteoarthritis
• diagnosis
• cell therapy
• platelet-rich plasma
• exosome
• knee osteotomy
• arthroplasty
• physiotherapy
• conservative treatment
• surgical treatment