Pelvic Organ Prolapse: Current Progress and Clinical Challenges

Dear Colleagues,

Pelvic organ prolapse (POP) is a significant health concern, affecting a substantial proportion of women, particularly during postmenopausal and post-childbirth phases. It occurs when pelvic organs like the bladder, uterus or rectum drop from their normal position and bulge into the vagina due to weakening of the muscles and tissues supporting these organs. This condition can cause discomfort, urinary problems and sexual dysfunction, severely impacting the quality of life.

Recent progress in understanding and managing POP includes advancements in diagnostic techniques, such as high-resolution imaging, which provides a detailed view of the pelvic anatomy and helps in precise identification of the prolapse. There has also been development in minimally invasive surgical techniques, such as laparoscopic and robotic surgeries, which offer quicker recovery and fewer complications compared to traditional surgeries.

However, clinical challenges remain. These include a need for better risk prediction and prevention strategies, especially for women at higher risk due to genetic factors or lifestyle. Additionally, the long-term efficacy and safety of surgical mesh, used in POP surgeries, are under scrutiny due to complications like mesh erosion. Thus, current research is also focused on developing new biomaterials for safer and more effective treatments.

Overall, while significant strides have been made in the treatment and management of POP, ongoing research and clinical trials are crucial for addressing the remaining challenges and improving patient outcomes.

Dr. Riccardo Lombardo
Dr. Cosimo De Nunzio
Guest Editors

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• pelvic organ prolapse (POP)
• postmenopausal
• urinary dysfunction
• minimally invasive surgery
• laparoscopic surgery
• robotic surgery
• surgical mesh